XClose

UCL Institute of Ophthalmology

Menu

Publications and dissemination

Abstract and poster presentations

  • Amanda Davis and Mr Gus Gazzard Glaucoma Service, Moorfields Eye Hospital, London, UK (2013). Co-ordinating a large pragmatic clinical trial- the role of the Ophthalmic CRF in facilitating trial management: Abstract and Poster acceptance at the UKCRN conference in Birmingham
  • Neil Nathwani, Amanda Davis, Evgenia Konstantakopoulou, Gus Gazzard Glaucoma Service, Moorfields Eye Hospital, London, UK (2015) "Reasons for non-participation in a randomised controlled trial and the effect of audiovisual material." Abstract and Poster acceptance to the 3rd International Clinical Trials Methodology Conference, Glasgow

Journals

  • Gazzard, G. et al. (2014). LiGHT: Health-Related Quality of Life in two treatment pathways for primary open angle glaucoma and ocular hypertension: a randomised controlled trial of initial selective laser trabeculoplasty versus conventional medical therapy. The Lancet.
  • Victoria Vickerstaff, Gareth Ambler, Catey Bunce, Wen Xing, Gus Gazzard and on behalf of the LiGHT study group: Statistical analysis plan for the Laser-1st vs Drops-1st for Glaucoma and Ocular Hypertension Trial (LiGHT): a multi-centre randomised controlled trial. Trials Journal. http://www.trialsjournal.com/content/16/1/517

Main report of the trial to the funder (NIHR HTA)

  • Selective laser trabeculoplasty versus drops for newly diagnosed ocular hypertension and glaucoma: the LiGHT RCT. Gazzard G, Konstantakopoulou E, Garway-Heath D, Garg A, Vickerstaff V, Hunter R, Ambler G, Bunce C, Wormald R, Nathwani N, Barton K, Rubin G, Morris S, Buszewicz M.Health Technol Assess. 2019 Jun;23(31):1-102
    See full article

Main results paper

  • Selective laser trabeculoplasty versus eye drops for first-line treatment of ocular hypertension and glaucoma (LiGHT): a multicentre randomised controlled trial. Gazzard G, Konstantakopoulou E, Garway-Heath D, Garg A, Vickerstaff V, Hunter R, Ambler G, Bunce C, Wormald R, Nathwani N, Barton K, Rubin G, Buszewicz M; LiGHT Trial Study Group. Lancet. 2019 Apr 13;393(10180):1505-1516
    See full article

Clinical outcomes of SLT

  • Primary Selective Laser Trabeculoplasty for Open-Angle Glaucoma and Ocular Hypertension: Clinical Outcomes, Predictors of Success, and Safety from the Laser in Glaucoma and Ocular Hypertension Trial. Garg A, Vickerstaff V, Nathwani N, Garway-Heath D, Konstantakopoulou E, Ambler G, Bunce C, Wormald R, Barton K, Gazzard G; Laser in Glaucoma and Ocular Hypertension Trial Study Group. Ophthalmology. 2019 Sep;126(9):1238-1248
    See full article

Baseline patient characteristics, trial design & statistical analysis plan

  • The Laser in Glaucoma and Ocular Hypertension (LiGHT) trial. A multicentre randomised controlled trial: baseline patient characteristics. Konstantakopoulou E, Gazzard G, Vickerstaff V, Jiang Y, Nathwani N, Hunter R, Ambler G, Bunce C; LiGHT Trial Study Group. Br J Ophthalmol. 2018 May;102(5):599-603
    See full article
     
  • Laser in Glaucoma and Ocular Hypertension (LiGHT) trial. A multicentre, randomised controlled trial: design and methodology. Gazzard G, Konstantakopoulou E, Garway-Heath D, Barton K, Wormald R, Morris S, Hunter R, Rubin G, Buszewicz M, Ambler G, Bunce C; LiGHT Trial Study Group. Br J Ophthalmol. 2018 May;102(5):593-598
    See full article
     
  • Statistical analysis plan for the Laser-1st versus Drops-1st for Glaucoma and Ocular Hypertension Trial (LiGHT): a multi-centre randomised controlled trial. Vickerstaff V, Ambler G, Bunce C, Xing W, Gazzard G; LiGHT Trial Study Group. Trials. 2015 Nov 11;16:517
    See full article