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UCL Queen Square Institute of Neurology

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Neurosurgery

 

Skull and chest radiographs pre & post intervention*

Using surgical techniques to correct neurological problems, and developing new ways to repair brain injury

Lead:

Mr Neil Kitchen

Research Team:

Research Goals

  • To advance the field of neurovascular surgery and understand related disturbances in cerebrospinal fluid dynamics
  • To conduct a range of studies in normal pressure hydrocephalus

Funded Research Projects

  • Study of intracranial pressure dynamics
  • Studying cerebrospinal fluid biomarkers
  • Imaging studies in normal pressure hydrocephalus
  • Recruiting to BASICS trial and TOPSAT2 to study cerebrovascular disease and hydrocephalus
Recent publications from Neurosurgery

Asif H, Craven CL, Siddiqui AH, Shah SN, Matloob SA, Thorne L, Robertson F, Watkins LD, Toma AK. Idiopathic intracranial hypertension: 120-day clinical, radiological, and manometric outcomes after stent insertion into the dural venous sinus. J Neurosurg 2018; 129(3):723-731.

Craven CL, Chapman MD, D'Antona L, Thompson SD, Lakdawala N, Zetterberg H, Watkins LD, Toma AK. Lumbar drains can affect CSF biomarker levels. Journal of Clinical Pathology, 2018 in press.

Alg VS, Ke X, Grieve J, Bonner S, Walsh DC, Bulters D, Kitchen N, Houlden H, Werring DJ. Association of functional MMP-2 gene variant with intracranial aneurysms: case-control genetic association study and meta-analysis. British Journal of Neurosurgery, online 15 Jan 2018.

Craven CL, Baudracco I, Thompson SD, Thorne L, Watkins LD, Toma AK. Transtentorial distortion syndrome: consistent complication following lateral and fourth ventricular shunting in adults. World Neurosurgery 2018; 110:e514-e519.

Funnell JP, Craven CL, D’Antona L, Thompson SD, Chari A, Thorne L, Watkins LD, Toma AK. Intracranial pressure in patients with papilloedema. Acta Neurologica Scandinavica, online 12 March 2018.

Craven CL, Baudracco I, Zetterberg H, Lunn MPT, Chapman MD, Lakdawala N, Watkins LD, Toma AK.  The predictive value of T-tau and AB1-42 levels in idiopathic normal pressure hydrocephalus.  Acta Neurochirurgica 2017; 159(12):2293-2300.  DOI:  10.1007/s00701-017-3314-x

Matharu MS, Miller S, Lagrata S, Watkins L.  Occipital nerve stimulation for medically refractory chronic paroxysmal hemicrania.  Headache 2017; 57(10):1610-1613. DOI: 10.1111/head.13187

Asif H, Craven CL, Siddiqui AH, Shah SN, Matloob SA, Thorne L, Robertson F, Watkins LD, Toma AK.  Idiopathic intracranial hypertension: 120-day clinical, radiological, and manometric outcomes after stent insertion into the dural venous sinus.  Journal of Neurosurgery, online 6 October 2017. DOI: 10.3171/2017.4.JNS162871

Craven CL, Baudracco I, Thompson SD, Thorne L, Watkins LD, Toma AK.  Transtentorial distortion syndrome:  a consistent complication following lateral and fourth ventricular shunting in adults.  World Neurosurgery, online 15 November 2017.  DOI:  10.1016/j.wneu.2017.11.032

Matloob SA, Toma AK, Thompson SD, Gan CL, Robertson F, Thorne L, Watkins LD. Effect of venous stenting on intracranial pressure in idiopathic intracranial hypertension. Acta Neurochirurgica 2017 Aug;159(8):1429-1437. doi: 10.1007/s00701-017-3229-6. Epub 2017 May 31.

Thompson SD, Shand Smith JD, Khan AA, Luoma AMV, Toma AK, Watkins LD. Shunting of the over 80s in normal pressure hydrocephalus. Acta Neurochirurgica 2017; 159(6):987-994 doi: 10.1007/s00701-017-3171-7. Epub 2017 Apr 18.

Hostettler Moreno I, Alg V, Shahi N, Jichi F, Bonner S, Walsh D, Bulters D, Kitchen N Brown M, Houlden H et al. Characteristics of unruptured compared to ruptured intracranial aneurysms: A multicentre case-control study. Neurosurgery,2017 Jul 25. doi: 10.1093/neuros/nyx365. [Epub ahead of print].

Craven CL, Toma AK, Watkins LD. Persistent hydrocephalus due to postural activation of a ventricular shunt anti-gravity device. Journal of Clinical Neuroscience 2017; 37:91-95 doi: 10.1016/j.jocn.2016.11.004. Epub 2016 Nov 24.

Thompson SD, Coutts A, Craven CL, Toma AK, Thorne LW, Watkins LD. Elective ICP monitoring: how long is long enough? Acta Neurochirurgica 2017; 159(3):485-490 doi: 10.1007/s00701-016-3074-z. Epub 2017 Jan 20.

Al-Mousa A, Bose G, Hunt K, Toma AK. Adenosine-assisted neurovascular surgery: initial case series and review of literature. Neurosurgical Review, online 22 July 2017doi: 10.1007/s10143-017-0883-3. [Epub ahead of print]

Craven CL, Toma AK, Watkins LD. Persistent hydrocephalus due to postural activation of a ventricular shunt anti-gravity device. J Clin Neurosci 2017; 37; 91-95. doi: 10.1016/j.jocn.2016.11.004. Epub 2016 Nov 24.

Craven CL, Toma AK, Mostafa T, Patel N, Watkins LD. The predictive value of DESH for shunt responsiveness in idiopathic normal pressure hydrocephalus. J Clin Neurosci 2016;34:294-298. doi: 10.1016/j.jocn.2016.09.004. Epub 2016 Sep 28.

Rojas-Villabona A, Kitchen N, Paddick I. Investigation of dosimetric differences between the TMR 10 and convolution algorithm for Gamma Knife stereotactic radiosurgery. J Appl Clin Med Phys. 2016 Nov 8;17(6):6347. doi: 10.1120/jacmp.v17i6.6347.

Further information

* Craven et al (2017). Persistent hydrocephalus due to postural activation of a ventricular shunt anti-gravity device. Journal of Clinical Neuroscience, Volume 37, March 2017, Pages 91-95. https://doi.org/10.1016/j.jocn.2016.11.004