QSBB Digital Pathology Resource

The University College London Queen’s Square Brain Bank (UCL QSBB) Digital Pathology Resource (RRID:SCR_025020) contains digital whole slide images from Lewy body disorders: Parkinson’s Disease, Parkinson’s Disease with Dementia and Dementia with Lewy Bodies, and control cases.

This Digital Pathology Resource in part is funded by Aligning Science Across Parkinson’s (ASAP 000478) through the Michael J. Fox Foundation for Parkinson’s Research (MJFF).

To view the QSBB Digital Pathology Resource registration form must be completed.

This Resource is available for viewing representative diagnostic slides, stained with Haematoxylin and Eosin, and immunostained for α-synuclein, amyloid-β, phosphorylated tau, TDP-43 and p62.

Files of the digital slides or any associated frozen or formalin-fixed paraffin embedded tissues or clinical and pathology data are available upon approval of the research proposal by the QSBB material transfer agreement committee. The MTA forms for the application are available here.

Terms of Use

Acceptance of the Agreement

Henceforth, the User will be referred to as the person who has been granted access to the Resource upon completion of the registration form, with the Owner of the Resource being UCL QSBB.

By accessing or using this Resource, you agree to be bound by these Terms of Use. If you do not agree to all the terms and conditions of this agreement, you may not access or use the Resource or access will be revoked.

Upon submission of the registration form, the application will be reviewed, and if found to comply with the stipulated minimum requirements, access will be granted within 10 working days.

Data Retention

By completing the registration form to access the Resource, the User agrees that all personal data provided by the User on the registration form will be retained and stored securely by the Owner as long as the User has access to the Resource. The retention and processing of personal data will be in accordance with UK Data Protection legislation and UCL Data Protection policy.

Changes to the Terms

UCL QSBB reserves the right to modify or update these Terms of Use at any time.

It is your responsibility to review these Terms of Use periodically for any changes. Continued use of the Resource after the posting of modifications indicates your acceptance of the modified terms.

Changes to the Resource

User agrees that the Resource may be modified, with the content removed, renamed or updated at tany time without notifying users of any changes made.

Intellectual Property

Users may not download, reproduce, distribute, or create derivative works based on the content available through the Resource without explicit permission from the UCL QSBB.

All trademarks, logos, and service marks displayed on the Resource are the property of their respective owners and may not be used without permission.

Rules for Users

Users are strictly prohibited from engaging in any activities that may disrupt, interfere with, or harm the functionality of the Resource.

Users are not permitted to attempt to reidentify any cases on the Resource.

Attempts to gain unauthorized access to, download or in any other way manipulate or modify the Resource, servers, or networks connected to the service are strictly prohibited.

Third-Party Content

Certain content or services on the Resource may be provided by third parties. Any such third-party content is subject to its own terms and conditions.

Termination of Accounts

UCL QSBB reserves the right to terminate or suspend user accounts without notice for violations of any conditions outlined in the Terms of Use.

General Disclaimers

• No Warranty:

        - The Resource is provided "as is" and "as available" without any warranties of any kind, either expressed or implied, including, but not limited to, the implied warranties of merchantability, fitness for a particular purpose, or non-infringement.

• Use at Your Own Risk:

        - Your use of the Resource is at your sole risk. UCL QSBB makes no representations or warranties that the service will meet your requirements, be uninterrupted, secure, or error-free.

• Content Accuracy:

        - UCL QSBB does not warrant the accuracy, completeness, or reliability of any content available through the service. You acknowledge and agree that reliance on any such content is at your own risk.

Liability

To the fullest extent permitted by applicable law, UCL QSBB shall not be liable for any indirect, incidental, special, consequential, or punitive damages, or any loss of profits or revenues, whether incurred directly or indirectly

Jurisdiction

The courts of England and Wales have exclusive jurisdiction to determine any dispute arising out of or in connection with use of the Resource (including in relation to any non-contractual obligations).

Any Party may seek specific performance, interim or final injunctive relief or any other relief of similar nature or effect in any court of competent jurisdiction.

Subject to above, users waive any objection to, and agree to submit to, the jurisdiction of the courts of England and Wales.

Governing Law

 

This Agreement and any non-contractual obligations arising out of or in connection with it will be governed by the law of England and Wales.

 

Acknowledgments

 

Prior to the production of any presentations/publications incorporating Resource material, the User shall contact UCL QSBB for a determination of acknowledgment to be made.

 

Explanation of folder and file labelling in the resources:

Folder names identify the case, e.g., P1-2002

File names identify the case, anatomical region and stain, e.g. P1-02_1_Abeta (“P1-02” is the case; “_1_” is the anatomical region;” Abeta” is the stain)

 

Glossary for the anatomical regions:

1: Anterior frontal lobe containing super and middle frontal gyri, with the notch on the superior frontal gyrus

2: Posterior frontal cortex, aimed at containing primary motor cortex

4: Temporal lobe, containing superior and middle temporal gyri, with the notch on the superior temporal gyrus

6: Parietal lobe containing superior and inferior parietal lobules, with the notch on the superior parietal lobule

7: Occipital lobe containing striate cortex

8: Anterior cingulate gyrus

9: Anterior hippocampus

10: Posterior hippocampus at the level of the lateral geniculate nucleus

11: Amygdala with peri-amygdala cortex

12:  Anterior basal ganglia at the level of nucleus accumbens

13: Mid-level basal ganglia at the level of anterior commissure

14: Posterior basal ganglia at the level of mamillary body

15: Thalamus with subthalamic nucleus

16: Midbrain at the level of the red nucleus

17: Midbrain at the level of the decussation of the superior cerebellar peduncle

18: Upper pons

19: Lower pons

20: Upper medulla

21: Lower medulla

23: Cerebellum with the dentate nucleus

34: Upper cervical spinal cord at the transition with medulla

38: Pineal gland

Glossary for the stains:

ABeta: amyloid-β

ASyn: α-synuclein

AT8: Hyperphosphorylated tau

TDP43: non-phosphorylated TDP43

pTDP43: phosphorylated TDP43

p62: p62 protein

H&E: Haematoxylin and Eosin