Pre-Clinical Models

• Biphasic osteochondral gel-base matrix system for mesenchymal stem cell differentiation

• Conjunctival scarring in the context of glaucoma filtration surgery (post-surgical scarring in the Tenon's capsule)
• Trachoma scarring: upper eyelid scarring during the progression of trachomatous trichiasis
• Thyroid Eye Disease (or Graves' Orbithopathy): orbital fibroblast adipogenesis and fibrosis

• Tubular collagen scaffolds for smooth muscle cells
• 3D bioengineered skeletal muscle constructs to mode aged phenotypes
• 3D collagen gel construct for the measurement of force generation
• 3D myotube constructs as a marker of muscle extracellular matrix remodeling

• Skin blister models:

a) Cantharidin-induced blisters 

b) Suction blisters with or without prior intra-dermal inoculation of heat-killed bacteria

c) Suction blister-induced skin windows coupled to an "exudate collecting chamber"

• RAFT and plastic compression rapid fabrication of tissues
• OOPS principle for mechano-control of cells (e.g. "Ultraband" garment device for reduction of skin scarring in pregnancy)

• Biocompatible collagen and biodegradable flat warp-knitted PLACL mesh scaffold for static cell culture
• Living skin equivalents (LSE) from collagen hydrogel encapsulated keratinocytes and fibroblasts under a mechanical compression protocol

• Intravenous endotoxemia - to induce systemic inflammation

• Ultra-rapid engineering of tissue-like constructs using plastic compression of type I collagen gels
• A four-strand grasp modified interlocking suture technique for a rapid collagen-based tendon repair model