Key Publications

Prominent papers published 2013-2018 are highlighted in the box below. For a comprehensive list of publications, follow the links to a researcher's IRIS Profile.

  1. CTLA-4: a moving target in immunotherapy. Rowshanravan B, Halliday N, Sansom DM. Blood. 2018 Jan 4;131(1):58-67.
  2. MAIT cells are chronically activated in patients with autoimmune liver disease and promote pro-fibrogenic hepatic stellate cell activation. Böttcher K, Rombouts K, Saffioti F, Roccarina D, Rosselli M, Hall A, Luong T, Tsochatzis EA, Thorburn D, Pinzani M. Hepatology. 2018 Jan 12.
  3. Papaioannou I, Xu S, Denton CP, Abraham DJ, Ponticos M. STAT3 controls COL1A2 enhancer activation cooperatively with JunB, regulates type I collagen synthesis  posttranscriptionally, and is essential for lung myofibroblast differentiation. Mol Biol Cell. 2018 Jan 15;29(2):84-95.
  4. Moreno-Moral A, Bagnati M, Koturan S, Ko JH, Fonseca C, Harmston N, Game L, Martin J, Ong V, Abraham DJ, Denton CP, Behmoaras J, Petretto E. Changes in macrophage transcriptome associate with systemic sclerosis and mediate GSDMA contribution to disease risk. Ann Rheum Dis. 2018 Jan 17.
  5. Dritsoula A, Papaioannou I, Guerra SG, Fonseca C, Martin J, Herrick AL, Abraham DJ, Denton CP, Ponticos M. The molecular basis for dysregulated activation of NKX2-5 in vascular remodelling of systemic sclerosis. Arthritis Rheumatol. 2018 Jan 17.
  6. Factors associated with disease progression in early-diagnosed pulmonary arterial hypertension associated with systemic sclerosis: longitudinal data from the DETECT cohort. Mihai C, Antic M, Dobrota R, Bonderman D, Chadha-Boreham H, Coghlan JG,Denton CP, Doelberg M, Grünig E, Khanna D, McLaughlin VV, Müller-Ladner U, Pope JE, Rosenberg DM, Seibold JR, Vonk MC, Distler O. Ann Rheum Dis. 2018 Jan;77(1):128-132.
  7. Human CD8(+) EMRA T cells display a senescence-associated secretory phenotype regulated by p38 MAPK. Callender LA, Carroll EC, Beal RWJ, Chambers ES, Nourshargh S, Akbar AN, Henson SM. Aging Cell. 2018 Feb;17(1).
  8. Development of a consensus core dataset in juvenile dermatomyositis for clinical use to inform research. McCann LJ, Pilkington CA, Huber AM, Ravelli A, Appelbe D, Kirkham JJ, Williamson PR, Aggarwal A, Christopher-Stine L, Constantin T, Feldman BM, Lundberg I, Maillard S, Mathiesen P, Murphy R, Pachman LM, Reed AM, Rider LG, van Royen-Kerkof A, Russo R, Spinty S, Wedderburn LR, Beresford MW. Ann Rheum Dis. 2018 Feb;77(2):241-250.
  1. Pharmacological Inhibition of Bromodomain Proteins Suppresses Retinal Inflammatory Diseaseand Downregulates Retinal Th17 Cells. Eskandarpour M, Alexander R, Adamson P, Calder VL. J Immunol. 2017 Feb 1;198(3):1093-1103.
  2. Riociguat for the treatment of pulmonary arterial hypertension associated with connective tissue disease: results from PATENT-1 and PATENT-2. Humbert M, Coghlan JG, Ghofrani HA, Grimminger F, He JG, Riemekasten G, Vizza CD, Boeckenhoff A, Meier C, de Oliveira Pena J, Denton CP. Ann Rheum Dis. 2017 Feb;76(2):422-426.
  3. Optical coherence tomography evaluation of pulmonary arterial vasculopathy in Systemic Sclerosis. Schwaiger JP, Loder CD, Dobarro D, Kaier T, Reddecliffe S, Schreiber BE, Handler C, Denton CP, Coghlan JG. Sci Rep. 2017 Feb 24;7:43304.
  4. Human regulatory B cells in health and disease: therapeutic potential. Mauri C, Menon M. J Clin Invest. 2017 Mar 1;127(3):772-779.
  5. CD161(+) Tconv and CD161(+) Treg Share a Transcriptional and Functional Phenotype despite Limited Overlap in TCRβ Repertoire. Duurland CL, Brown CC, O'Shaughnessy RF, Wedderburn LR.. Front Immunol. 2017 Mar 6;8:103.
  6. Identifying functional defects in patients with immune dysregulation due to LRBA and CTLA-4 mutations. Hou TZ, Verma N, Wanders J, Kennedy A, Soskic B, Janman D, Halliday N, Rowshanravan B, Worth A, Qasim W, Baxendale H, Stauss H, Seneviratne S, Neth O, Olbrich P, Hambleton S, Arkwright PD, Burns SO, Walker LS, Sansom DM. Blood. 2017 Mar 16;129(11):1458-1468.
  7. A sestrin-dependent Erk-Jnk-p38 MAPK activation complex inhibits immunity during aging. Lanna A, Gomes DC, Muller-Durovic B, McDonnell T, Escors D, Gilroy DW, Lee JH, Karin M, Akbar AN. Nat Immunol. 2017 Mar;18(3):354-363.
  8. Pre/pro-B cells generate macrophage populations during homeostasis and inflammation. Audzevich T, Bashford-Rogers R, Mabbott NA, Frampton D, Freeman TC, Potocnik A, Kellam P, Gilroy DW. Proc Natl Acad Sci U S A. 2017 May 16;114(20):E3954-E3963.
  9. Prostacyclins have no direct inotropic effect on isolated atrial strips from the normal and pressure-overloaded human right heart.  Holmboe S, Andersen A, Jensen RV, Kimose HH, Ilkjær LB, Shen L,Clapp LH, Nielsen-Kudsk JE. Pulm Circ. 2017 Apr-Jun;7(2):339-347.
  10. The fate and lifespan of human monocyte subsets in steady state and systemic inflammation. Patel AA, Zhang Y, Fullerton JN, Boelen L, Rongvaux A, Maini AA, Bigley V, Flavell RA, Gilroy DW, Asquith B, Macallan D, Yona S. J Exp Med. 2017 Jul 3;214(7):1913-1923.
  11. The transcription factor Gli3 promotes B cell development in fetal liver through repression of Shh.  Solanki A, Lau CI, Saldaña JI, Ross S, Crompton T. J Exp Med. 2017 Jul 3;214(7):2041-2058.
  12. Initial combination therapy with ambrisentan and tadalafil in connective tissue disease-associated pulmonary arterial hypertension (CTD-PAH): subgroup analysis from the AMBITION trial. Coghlan JG, Galiè N, Barberà JA, Frost AE, Ghofrani HA, Hoeper MM, Kuwana M, McLaughlin VV, Peacock AJ, Simonneau G, Vachiéry JL, Blair C, Gillies H, Miller KL, Harris JHN, Langley J, Rubin LJ;AMBITION investigators. Ann Rheum Dis. 2017 Jul;76(7):1219-1227.
  13. Surrogate endpoints for clinical trials in non-alcoholic steatohepatitis. Tsochatzis EA, Buzzetti E, Pinzani M. Lancet Gastroenterol Hepatol. 2017 Aug;2(8):549-550.
  14. CD4 T-Cell Dysregulation in Psoriatic Arthritis Reveals a Regulatory Role for IL-22. Ezeonyeji A, Baldwin H, Vukmanovic-Stejic M, Ehrenstein MR. Front Immunol. 2017 Oct 27;8:1403.
  15. Systemic Sclerosis. Denton CP, Khanna D. Lancet. 2017 Oct 7;390(10103):1685-1699.
  16. Defective regulation of autoreactive IL-6-producing transitional B lymphocytes is associated with disease in patients with systemic sclerosis. Taher TE, Ong VH, Bystrom J, Hillion S, Simon Q, Denton CP, Pers JO, Abraham DJ, Mageed RA. Arthritis Rheumatol. 2017 Nov 28.
  17. A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells. Johnston CJC, Smyth DJ, Kodali RB, White MPJ, Harcus Y, Filbey KJ, Hewitson JP, Hinck CS, Ivens A, Kemter AM, Kildemoes AO, Le Bihan T, Soares DC, Anderton SM, Brenn T, Wigmore SJ, Woodcock HV, Chambers RC, Hinck AP, McSorley HJ, Maizels RM. Nat Commun. 2017 Nov 23;8(1):1741.
  18. Acute Respiratory Distress Syndrome. Thompson BT, Chambers RC, Liu KD. N Engl J Med. 2017 Nov 9;377(19):1904-1905.
  19. Fibroblasts and extracellular matrix: Targeting and therapeutic tools in fibrosis and cancer. Prakash J, Pinzani M. Adv Drug Deliv Rev. 2017 Nov 1;121:1-2.


  1. pDC and B regs. Mauri C. Immunity.2016 Mar 15;44 (3):683-97. 
  2. Mediators of inflammatory resolution. Gilroy D. Proc Natl Acad Sci USA. 2016 Jun 7; 113 (23):E3240-9. 
  3. Novel metabolic anti-fibrotics. Dart J. JCI Insight. 2016 Aug 4;1(12):e87001.
  4. Anti-TNF and rheumatoid arthritis. Ehrenstein M. J Exp Med. 2016 Jun 27; 213(7):1241-53. 
  5. Research in paediatric rheumatology. Wedderburn L. Nat Rev Rheumatol. 2016 Nov; 12 (11):684-690). 
  6. Optimizing T-cell receptor gene therapy. Blood. Stauss H. 2016 Jun 30; 127 (26):3305-11. 
  1. Satellite cells from dystrophic muscle retain regenerative capacity. Boldrin L, Zammit PS,Morgan JE. Stem Cell Res.2015 Jan;14(1):20-9.
  2. The transcriptional activator Gli2 modulates T-cell receptor signalling through attenuation of AP-1 and NFκB activity. Furmanski AL, Barbarulo A, Solanki A, Lau CI, Sahni H, Saldana JI, D'Acquisto F, Crompton T. J Cell Sci.2015 Jun 1;128(11):2085-95.
  3. HIF1α allows monocytes to take a breather during sepsis. Gilroy DW, Yona S. Immunity 2015 Mar 17;42(3):397-9.
  4. Metabolic regulation of hepatitis B immunopathology by myeloid-derived suppressor cells. Pallett LJ, Gill US, Quaglia A, Sinclair LV, Jover-Cobos M, Schurich A, Singh KP, Thomas N, Das A, Chen A, Fusai G, Bertoletti A, Cantrell DA, Kennedy PT, Davies NA, Haniffa M, Maini MK. Nat Med.2015 Jun;21(6):591-600. 
  5. Virus-specific T lymphocytes home to the skin during natural dengue infection. Rivino L, Kumaran EA, Thein TL, Too CT, Gan VC, Hanson BJ, Wilder-Smith A, Bertoletti A, Gascoigne NR, Lye DC, Leo YS, Akbar AN, Kemeny DM, MacAry PA. Sci Transl Med.2015 Mar 11;7(278):278ra35.
  6. Regulatory B cells: origin, phenotype, and function. Rosser EC, Mauri C. Immunity 2015 Apr 21;42(4):607-12. 
  7. The p38 mitogen-activated protein kinase cascade modulates T helper type 17 differentiation and functionality in multiple sclerosis. Di Mitri D, Sambucci M, Loiarro M, De Bardi M, Volpe E, Cencioni MT, Gasperini C, Centonze D, Sette C, Akbar AN, Borsellino G, Battistini L. Immunology 2015 Oct;146(2):251-63. 
  8. Endothelial to Mesenchymal Transition Contributes to Endothelial Dysfunction in Pulmonary Arterial Hypertension.  Good RB, Gilbane AJ, Trinder SL, Denton CP, Coghlan G, Abraham DJ, Holmes AM. Am J Pathol. 2015 Jul;185(7):1850-8.
  9. The many faces of type I interferon in systemic lupus erythematosus. Mauri C, Menon M. J Clin Invest. 2015 Jul 1;125(7):2562-4.
  10. Failed degradation of JunB contributes to overproduction of type I collagen and development of dermal fibrosis in patients with systemic sclerosis. Ponticos M, Papaioannou I, Xu S, Holmes AM, Khan K, Denton CP, Bou-Gharios G, Abraham DJ. Arthritis Rheumatol. 2015 Jan;67(1):243-53.
  11. Rod disc renewal occurs by evagination of the ciliary plasma membrane that makes cadherin-based contacts with the inner segment. Burgoyne T, Meschede IP, Burden JJ, Bailly M, Seabra MC, Futter CE. Proc Natl Acad Sci U S A. 2015 Dec 29;112(52):15922-7.
  12. Regulation of neutrophilic inflammation by proteinase-activated receptor 1 during bacterial pulmonary infection. José RJ, Williams AE, Mercer PF, Sulikowski MG, Brown JS, Chambers RC. J Immunol. 2015 Jun 15;194(12):6024-34.
  13. Human corneal stromal stem cells support limbal epithelial cells cultured on RAFT tissue equivalents. Kureshi AK, Dziasko M, Funderburgh JL, Daniels JT. Sci Rep. 2015 Nov 4;5:16186. 
  14. Selexipag for the Treatment of Pulmonary Arterial Hypertension. Sitbon O, Channick R, Chin KM, Frey A, Gaine S, Galiè N, Ghofrani HA, Hoeper MM, Lang IM, Preiss R, Rubin LJ, Di Scala L, Tapson V, Adzerikho I, Liu J, Moiseeva O, Zeng X, Simonneau G, McLaughlin VV; GRIPHON Investigators. N Engl J Med. 2015 Dec 24;373(26):2522-33.
  15. TNFα Regulates SIRT1 Cleavage during Ocular Autoimmune Disease. Gardner PJ, Yazid S, Chu CJ, Copland DA, Adamson P, Dick AD, Calder VL. Am J Pathol. 2015 May;185(5):1324-33.
  1. Recurrent HCV after liver transplantation-mechanisms, assessment and therapy. Joshi D,Pinzani M, Carey I, Agarwal K. Nat Rev Gastroenterol Hepatol. 2014Dec;11(12):710-21.
  2. Regulatory B cells are induced by gut microbiota-driven interleukin-1β and interleukin-6 production. Rosser EC, Oleinika K, Tonon S, Doyle R, Bosma A, Carter NA, Harris KA, Jones SA, Klein N, Mauri C. Nat Med. 2014 Nov;20(11):1334-9.
  3. Resolution of acute inflammation bridges the gap between innate and adaptive immunity. Newson J, Stables M, Karra E, Arce-Vargas F, Quezada S, Motwani M, Mack M, Yona S, Audzevich T, Gilroy DW. Blood. 2014 Sep 11;124(11):1748-64.
  4. Immunosuppression in acutely decompensated cirrhosis is mediated by prostaglandin E2. O'Brien AJ, Fullerton JN, Massey KA, Auld G, Sewell G, James S, Newson J, Karra E, Winstanley A, Alazawi W, Garcia-Martinez R, Cordoba J, Nicolaou A, Gilroy DW. Nat Med. 2014 May;20(5):518-23. Arthritis Rheumatol. 2014 Oct;66(10):2694-705.
  5. Induced CD8+FoxP3+ Treg cells in rheumatoid arthritis are modulated by p38 phosphorylation and monocytes expressing membrane tumor necrosis factor α and CD86. Ellis SDI, McGovern JL, van Maurik A, Howe D, Ehrenstein MR, Notley CA. 
  6. The kinase p38 activated by the metabolic regulator AMPK and scaffold TAB1 drives the senescence of human T cells. Lanna A, Henson SM, Escors D, Akbar AN. Nat Immunol. 2014 Oct;15(10):965-72.
  7. Systemic lupus erythematosus. Lisnevskaia L, Murphy G, Isenberg D. Lancet. 2014 Nov 22;384(9957):1878-88.
  8. Changes in regulation of human monocyte proteins in response to IgG from patients with antiphospholipid syndrome. Ripoll VM, Lambrianides A, Pierangeli SS, Poulton K, Ioannou Y, Heywood WE, Mills K, Latchman DS, Isenberg DA, Rahman A, Giles IP. Blood. 2014 Dec 11;124(25):3808-16.
  9. Interstitial lung disease in connective tissue disease--mechanisms and management. Wells AU, Denton CP. Nat Rev Rheumatol. 2014 Dec;10(12):728-39.
  10. The coming of age of adolescent rheumatology. Eleftheriou D, Isenberg DA, Wedderburn LR, Ioannou Y. Nat Rev Rheumatol. 2014 Mar;10(3):187-93.
  11. Effect of high-dose simvastatin on brain atrophy and disability in secondary progressive multiple sclerosis (MS-STAT): a randomised, placebo-controlled, phase 2 trial. Chataway J, Schuerer N, Alsanousi A, Chan D, MacManus D, Hunter K, Anderson V, Bangham CR, Clegg S, Nielsen C, Fox NC, Wilkie D, Nicholas JM, Calder VL, Greenwood J, Frost C, Nicholas R. Lancet. 2014 Jun 28;383(9936):2213-21.
  1. De Lauretis, A., Sestini, P., Pantelidis, P., Hoyles, R., Hansell, D. M., Goh, N. S., Renzoni, E. A. (2013). Serum interleukin 6 is predictive of early functional decline and mortality in interstitial lung disease associated with systemic sclerosis. J Rheumatol, 40 (4), 435-446.
  2. Griffiths, S. J., Riddell, N. E., Masters, J., Libri, V., Henson, S. M., Wertheimer, A., Akbar, A. N. (2013). Age-associated increase of low-avidity cytomegalovirus-specific CD8+ T cells that re-express CD45RA. J Immunol, 190 (11), 5363-5372. 
  3. Vukmanovic-Stejic, M., Sandhu, D., Sobande, T. O., Agius, E., Lacy, K. E., Riddell, N., Akbar, A. N. (2013). Varicella zoster-specific CD4+Foxp3+ T cells accumulate after cutaneous antigen challenge in humans. J Immunol, 190 (3), 977-986.
  4. Hoare, M., Shankar, A., Shah, M., Rushbrook, S., Gelson, W., Davies, S., Alexander, G. J. M. (2013). gamma-H2AX+CD8+T lymphocytes cannot respond to IFN-alpha, IL-2 or IL-6 in chronic hepatitis C virus infection. JOURNAL OF HEPATOLOGY, 58 (5), 868-874.
  5. Balasubramaniyan, V., Dhar, D. K., Warner, A. E., Vivien Li, W. Y., Amiri, A. F., Bright, B., Jalan, R. (2013). Importance of Connexin-43 based gap junction in cirrhosis and acute-on-chronic liver failure. J Hepatol, 58 (6), 1194-1200. 
  6. Furmanski, A. L., O'Shaughnessy, R. F., Saldana, J. I., Blundell, M. P., Thrasher, A. J., Sebire, N. J., Crompton, T. (2013). T-cell reconstitution after thymus xenotransplantation induces hair depigmentation and loss. J Invest Dermatol, 133 (5), 1221-1230.
  7. Carter, L. M., Isenberg, D. A., & Ehrenstein, M. R. (2013). Elevated serum B-cell activating factor (BAFF / BLyS) is associated with rising anti-dsDNA antibody levels and flare following B-cell depletion therapy in systemic lupus erythematosus. Arthritis Rheum. doi:10.1002/art.38074.
  8. Calhabeu, F., Hayashi, S., Morgan, J. E., Relaix, F., & Zammit, P. S. (2013). Alveolar rhabdomyosarcoma-associated proteins PAX3/FOXO1A and PAX7/FOXO1A suppress the transcriptional activity of MyoD-target genes in muscle stem cells.ONCOGENE, 32 (5), 651-662.
  9. Boldrin, L., & Morgan, J. E. (2013). Grafting of a single donor myofibre promotes hypertrophy in dystrophic mouse muscle.PLoS One, 8 (1), e54599-?
  10. Berzigotti, A., Seijo, S., Arena, U., Abraldes, J. G., Vizzutti, F., García-Pagán, J. C., Bosch, J. (2013). Elastography, spleen size, and platelet count identify portal hypertension in patients with compensated cirrhosis. Gastroenterology, 144 (1), 102-111.
  11. Arena, U., Platon, M. L., Stasi, C., Moscarella, S., Assarat, A., Bedogni, G., . . . Pinzani, M. (2013). Liver stiffness is influenced by a standardized meal in patients with chronic hepatitis C virus at different stages of fibrotic evolution. Hepatology, 58 (1), 65-72.
  12. Wulffraat, N. M., & Woo, P. (2013). Canakinumab in pediatric rheumatic diseases. EXPERT OPINION ON BIOLOGICAL THERAPY, 13 (4), 615-622. 
  13. Hinks, A., Cobb, J., Marion, M. C., Prahalad, S., Sudman, M., Bowes, J.,  Thompson, S. D. (2013). Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis. Nat Genet, 45 (6), 664-669.
  14. Woo, P., & Humphries, S. E. (2013). IL-6 polymorphisms: a useful genetic tool for inflammation research?. JOURNAL OF CLINICAL INVESTIGATION, 123 (4), 1413-1414.
  15. Ter Haar, N., Lachmann, H., Özen, S., Woo, P., Uziel, Y., Modesto, C., aediatric Rheumatology International Trials Organisation (PRINTO) and the Eurofever/Eurotraps Projects. (2013). Treatment of autoinflammatory diseases: results from the Eurofever Registry and a literature review. Ann Rheum Dis, 72 (5), 678-685.