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Key Publications


Prominent papers published 2015-2020 are highlighted in the box below. For a comprehensive list of publications, follow the links to a researcher's IRIS Profile.

2020

  1. Microbiota-Derived Metabolites Suppress Arthritis by Amplifying Aryl-Hydrocarbon Receptor Activation in Regulatory B Cells. Rosser EC, Piper CJM, Matei DE, Blair PA, Rendeiro AF, Orford M, Alber DG, Krausgruber T, Catalan D, Klein N, Manson JJ, Drozdov I, Bock C, Wedderburn LR, Eaton S, Mauri C.Cell Metab. 2020 Apr 7;31(4):837-851.e10. doi: 10.1016/j.cmet.2020.03.003.
  2. Aging immunity may exacerbate COVID-19. Akbar AN, Gilroy DW.Science. 2020 Jul 17;369(6501):256-257. doi: 10.1126/science.abb0762
  3. Blocking elevated p38 MAPK restores efferocytosis and inflammatory resolution in the elderly.De Maeyer RPH, van de Merwe RC, Louie R, Bracken OV, Devine OP, Goldstein DR, Uddin M, Akbar AN, Gilroy DW.Nat Immunol. 2020 Jun;21(6):615-625. doi: 10.1038/s41590-020-0646-0. 
  4. Sestrins induce natural killer function in senescent-like CD8+ T cells. Pereira BI, De Maeyer RPH, Covre LP, Nehar-Belaid D, Lanna A, Ward S, Marches R, Chambers ES, Gomes DCO, Riddell NE, Maini MK, Teixeira VH, Janes SM, Gilroy DW, Larbi A, Mabbott NA, Ucar D, Kuchel GA, Henson SM, Strid J, Lee JH, Banchereau J, Akbar AN.Nat Immunol. 2020 Jun;21(6):684-694. doi: 10.1038/s41590-020-0643-3. 
  5. Chronic inflammation in the etiology of disease across the life span. Furman D, Campisi J, Verdin E, Carrera-Bastos P, Targ S, Franceschi C, Ferrucci L, Gilroy DW, Fasano A, Miller GW, Miller AH, Mantovani A, Weyand CM, Barzilai N, Goronzy JJ, Rando TA, Effros RB, Lucia A, Kleinstreuer N, Slavich GM.Nat Med. 2019 Dec;25(12):1822-1832. doi: 10.1038/s41591-019-0675-0.
  6. Therapeutic blockade of granulocyte macrophage colony-stimulating factor in COVID-19-associated hyperinflammation: challenges and opportunities. Mehta P, Porter JC, Manson JJ, Isaacs JD, Openshaw PJM, McInnes IB, Summers C, Chambers RC.Lancet Respir Med. 2020 Aug;8(8):822-830. doi: 10.1016/S2213-2600(20)30267-8.
  7. The circadian clock protein REVERBα inhibits pulmonary fibrosis development. Cunningham PS, Meijer P, Nazgiewicz A, Anderson SG, Borthwick LA, Bagnall J, Kitchen GB, Lodyga M, Begley N, Venkateswaran RV, Shah R, Mercer PF, Durrington HJ, Henderson NC, Piper-Hanley K, Fisher AJ, Chambers RC, Bechtold DA, Gibbs JE, Loudon AS, Rutter MK, Hinz B, Ray DW, Blaikley JF.Proc Natl Acad Sci U S A. 2020 Jan 14;117(2):1139-1147.
  8. Deep phenotyping detects a pathological CD4+ T-cell complosome signature in systemic sclerosis. Arbore G, Ong VH, Costantini B, Denton CP, Abraham D, Placais L, Blighe K, Mitchell L, Ellis R, Heck S, Nocerino P, Woodruff TM, Kordasti S, Kemper C, Hourcade DE.Cell Mol Immunol. 2020 Jan 23. doi: 10.1038/s41423-019-0360-8.
  9. Raynaud phenomenon and digital ulcers in systemic sclerosis. Hughes M, Allanore Y, Chung L, Pauling JD, Denton CP, Matucci-Cerinic M.Nat Rev Rheumatol. 2020 Apr;16(4):208-221.
  10. Challenges in evidence-based therapy for systemic sclerosis associated interstitial lung disease. Denton CP, Ong VH.Lancet Respir Med. 2020 Mar;8(3):226-227.
  11. Predicting conversion to wet age-related macular degeneration using deep learning. Yim J, Chopra R, Spitz T, Winkens J, Obika A, Kelly C, Askham H, Lukic M, Huemer J, Fasler K, Moraes G, Meyer C, Wilson M, Dixon J, Hughes C, Rees G, Khaw PT, Karthikesalingam A, King D, Hassabis D, Suleyman M, Back T, Ledsam JR, Keane PA, De Fauw J.Nat Med. 2020 Jun;26(6):892-899.
  12. Meta-analysis of 542,934 subjects of European ancestry identifies new genes and mechanisms predisposing to refractive error and myopia. Hysi PG, Choquet H, Khawaja AP, Wojciechowski R, Tedja MS, Yin J, Simcoe MJ, Patasova K, Mahroo OA, Thai KK, Cumberland PM, Melles RB, Verhoeven VJM, Vitart V, Segre A, Stone RA, Wareham N, Hewitt AW, Mackey DA, Klaver CCW, MacGregor S; Consortium for Refractive Error and Myopia, Khaw PT, Foster PJ; UK Eye and Vision Consortium, Guggenheim JA; 23andMe Inc., Rahi JS, Jorgenson E, Hammond CJ.Nat Genet. 2020 Apr;52(4):401-407.
  13. TGF-β1-driven reduction of cytoglobin leads to oxidative DNA damage in stellate cells during non-alcoholic steatohepatitis. Okina Y, Sato-Matsubara M, Matsubara T, Daikoku A, Longato L, Rombouts K, Thanh Thuy LT, Ichikawa H, Minamiyama Y, Kadota M, Fujii H, Enomoto M, Ikeda K, Yoshizato K, Pinzani M, Kawada N.J Hepatol. 2020 Apr 21:S0168-8278(20)30228-2. doi: 10.1016/j.jhep.2020.03.051
  14. The stratification of cirrhosis. Maurice J, Pinzani M.Hepatol Res. 2020 May;50(5):535-541. doi: 10.1111/hepr.13493.
  15. Management of anticoagulant-refractory thrombotic antiphospholipid syndrome. Cohen H, Sayar Z, Efthymiou M, Gaspar P, Richards T, Isenberg D.Lancet Haematol. 2020 Aug;7(8):e613-e623. doi: 10.1016/S2352-3026(20)30116-2.
  16. Methotrexate reduces withdrawal rates of TNF inhibitors due to ineffectiveness in rheumatoid arthritis but only in patients who are seropositive. Greenwood M, Shipa M, Yeoh SA, Roussou E, Mukerjee D, Ehrenstein MR.Ann Rheum Dis. 2020 May 28:annrheumdis-2020-217725. doi: 10.1136/annrheumdis-2020-217725.
  17. Diapedesis-Induced Integrin Signaling via LFA-1 Facilitates Tissue Immunity by Inducing Intrinsic Complement C3 Expression in Immune Cells. Kolev M, West EE, Kunz N, Chauss D, Moseman EA, Rahman J, Freiwald T, Balmer ML, Lötscher J, Dimeloe S, Rosser EC, Wedderburn LR, Mayer-Barber KD, Bohrer A, Lavender P, Cope A, Wang L, Kaplan MJ, Moutsopoulos NM, McGavern D, Holland SM, Hess C, Kazemian M, Afzali B, Kemper C.Immunity. 2020 Mar 17;52(3):513-527.e8. doi: 10.1016/j.immuni.2020.02.006.
  18. The IFITM protein family in adaptive immunity. Yánez DC, Ross S, Crompton T.Immunology. 2020 Apr;159(4):365-372.
  19. Whole-genome sequencing of patients with rare diseases in a national health system. Turro E, Astle WJ, Megy K, Gräf S, Greene D, Shamardina O, Allen HL, Sanchis-Juan A, Frontini M, Thys C, Stephens J, Mapeta R, Burren OS, Downes K, Haimel M, Tuna S, Deevi SVV, Aitman TJ, Bennett DL, Calleja P, Carss K, Caulfield MJ, Chinnery PF, Dixon PH, Gale DP, James R, Koziell A, Laffan MA, Levine AP, Maher ER, Markus HS, Morales J, Morrell NW, Mumford AD, Ormondroyd E, Rankin S, Rendon A, Richardson S, Roberts I, Roy NBA, Saleem MA, Smith KGC, Stark H, Tan RYY, Themistocleous AC, Thrasher AJ, Watkins H, Webster AR, Wilkins MR, Williamson C, Whitworth J, Humphray S, Bentley DR; NIHR BioResource for the 100,000 Genomes Project, Kingston N, Walker N, Bradley JR, Ashford S, Penkett CJ, Freson K, Stirrups KE, Raymond FL, Ouwehand WH.Nature. 2020 Jul;583(7814):96-102. doi: 10.1038/s41586-020-2434-2.
  20. Characterization of GDF2 Mutations and Levels of BMP9 and BMP10 in Pulmonary Arterial Hypertension. Hodgson J, Swietlik EM, Salmon RM, Hadinnapola C, Nikolic I, Wharton J, Guo J, Liley J, Haimel M, Bleda M, Southgate L, Machado RD, Martin JM, Treacy CM, Yates K, Daugherty LC, Shamardina O, Whitehorn D, Holden S, Bogaard HJ, Church C, Coghlan G, Condliffe R, Corris PA, Danesino C, Eyries M, Gall H, Ghio S, Ghofrani HA, Gibbs JSR, Girerd B, Houweling AC, Howard L, Humbert M, Kiely DG, Kovacs G, Lawrie A, MacKenzie Ross RV, Moledina S, Montani D, Olschewski A, Olschewski H, Ouwehand WH, Peacock AJ, Pepke-Zaba J, Prokopenko I, Rhodes CJ, Scelsi L, Seeger W, Soubrier F, Suntharalingam J, Toshner MR, Trembath RC, Vonk Noordegraaf A, Wort SJ, Wilkins MR, Yu PB, Li W, Gräf S, Upton PD, Morrell NW.Am J Respir Crit Care Med. 2020 Mar 1;201(5):575-585.
  21. Whole-genome sequencing of a sporadic primary immunodeficiency cohort. Thaventhiran JED, Lango Allen H, Burren OS, Rae W, Greene D, Staples E, Zhang Z, Farmery JHR, Simeoni I, Rivers E, Maimaris J, Penkett CJ, Stephens J, Deevi SVV, Sanchis-Juan A, Gleadall NS, Thomas MJ, Sargur RB, Gordins P, Baxendale HE, Brown M, Tuijnenburg P, Worth A, Hanson S, Linger RJ, Buckland MS, Rayner-Matthews PJ, Gilmour KC, Samarghitean C, Seneviratne SL, Sansom DM, Lynch AG, Megy K, Ellinghaus E, Ellinghaus D, Jorgensen SF, Karlsen TH, Stirrups KE, Cutler AJ, Kumararatne DS, Chandra A, Edgar JDM, Herwadkar A, Cooper N, Grigoriadou S, Huissoon AP, Goddard S, Jolles S, Schuetz C, Boschann F; Primary Immunodeficiency Consortium for the NIHR Bioresource, Lyons PA, Hurles ME, Savic S, Burns SO, Kuijpers TW, Turro E, Ouwehand WH, Thrasher AJ, Smith KGC.Nature. 2020 Jul;583(7814):90-95. doi: 10.1038/s41586-020-2265-1.
  22. Restoration of Functional Full-Length Dystrophin After Intramuscular Transplantation of Foamy Virus-Transduced Myoblasts. Meng J, Sweeney NP, Doreste B, Muntoni F, McClure M, Morgan J.Hum Gene Ther. 2020 Feb;31(3-4):241-252. doi: 10.1089/hum.2019.224
  23. Irradiation dependent inflammatory response may enhance satellite cell engraftment. Doreste B, Torelli S, Morgan J.Sci Rep. 2020 Jul 6;10(1):11119. doi: 10.1038/s41598-020-68098-9.
  24. A validated porcine corneal organ culture model to study the limbal response to corneal epithelial injury. Seyed-Safi AG, Daniels JT.Exp Eye Res. 2020 May 14;197:108063. doi: 10.1016/j.exer.2020.108063.
  25. Cancer-associated fibroblasts mediate cancer progression and remodel the tumouroid stroma. Pape J, Magdeldin T, Stamati K, Nyga A, Loizidou M, Emberton M, Cheema U.Br J Cancer. 2020 Jul 9. doi: 10.1038/s41416-020-0973-9.
  26. The anti-angiogenic tyrosine kinase inhibitor Pazopanib kills cancer cells and disrupts endothelial networks in biomimetic three-dimensional renal tumouroids. Stamati K, Redondo PA, Nyga A, Neves JB, Tran MG, Emberton M, Cheema U, Loizidou M.J Tissue Eng. 2020 May 18;11:2041731420920597.
  27. Analysis of anti-RNA polymerase III antibody positive systemic sclerosis suggests altered GPATCH2L and CTNND2 expression in scleroderma renal crisis. Stern EP, Guerra SG, Chinque H, Acquaah V, González-Serna D, Ponticos M, Martin J, Ong VH, Khan K, Nihtyanova SI, Harber M, Burns A, Mayes MD, Assassi S, Fonseca C, Denton CP.J Rheumatol. 2020 Mar 15:jrheum.190945. doi: 10.3899/jrheum.190945.
  28. Functionally Distinct IFNγ+ IL-17A+ Th cells in experimental autoimmune uveitis: T cell heterogeneity, migration and steroid response. Chen YH, Eskandarpour M, Gondrand A, Zhang X, Gu R, Galatowicz G, Lightman SL, Calder VL.Eur J Immunol. 2020 Jul 11. doi: 10.1002/eji.202048616.
  29. Genome-Wide Association Study Reveals a Novel Association Between MYBPC3 Gene Polymorphism, Endurance Athlete Status, Aerobic Capacity and Steroid Metabolism. Al-Khelaifi F, Yousri NA, Diboun I, Semenova EA, Kostryukova ES, Kulemin NA, Borisov OV, Andryushchenko LB, Larin AK, Generozov EV, Miyamoto-Mikami E, Murakami H, Zempo H, Miyachi M, Takaragawa M, Kumagai H, Naito H, Fuku N, Abraham D, Hingorani A, Donati F, Botrè F, Georgakopoulos C, Suhre K, Ahmetov II, Albagha O, Elrayess MA.Front Genet. 2020 Jun 16;11:595. doi: 10.3389/fgene.2020.00595.
  30. Metabolic GWAS of elite athletes reveals novel genetically-influenced metabolites associated with athletic performance. Al-Khelaifi F, Diboun I, Donati F, Botrè F, Abraham D, Hingorani A, Albagha O, Georgakopoulos C, Suhre K, Yousri NA, Elrayess MA.Sci Rep. 2019 Dec 27;9(1):19889. doi: 10.1038/s41598-019-56496-7.

2019

  1. Is Resolution the End of Inflammation? Feehan KT, Gilroy DW.  Trends Mol Med. 2019 Mar;25(3):198-214.
  2. Presence of anti-rituximab antibodies predicts infusion-related reactions in patients with systemic lupus erythematosus. Wincup C, Menon M, Smith E, Schwartz A, Isenberg D, Jury EC, Mauri C; ABIRISK Consortium.Ann Rheum Dis. 2019 Aug;78(8):1140-1142.
  3. Aryl Hydrocarbon Receptor Contributes to the Transcriptional Program of IL-10-Producing Regulatory B Cells. Piper CJM, Rosser EC, Oleinika K, Nistala K, Krausgruber T, Rendeiro AF, Banos A, Drozdov I, Villa M, Thomson S, Xanthou G, Bock C, Stockinger B, Mauri C. Cell Rep. 2019 Nov 12;29(7):1878-1892
  4. GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways. López-Isac E, et al .,  Nat Commun. 2019 Oct 31;10(1):4955. doi: 10.1038/s41467-019-12760-y.
  5. Fibroblast-specific deletion of interleukin-1 receptor-1 reduces adverse cardiac remodeling following myocardial infarction. Bageghni SA, Hemmings KE, Yuldasheva NY, Maqbool A, Gamboa-Esteves FO, Humphreys NE, Jackson MS, Denton CP, Francis S, Porter KE, Ainscough JF, Pinteaux E, Drinkhill MJ, Turner NA. JCI Insight. 2019 Aug 8;5. pii: 125074. doi: 10.1172/jci.insight.125074.
  6. Nintedanib for Systemic Sclerosis-Associated Interstitial Lung Disease. Distler O, Highland KB, Gahlemann M, Azuma A, Fischer A, Mayes MD, Raghu G, Sauter W, Girard M, Alves M, Clerisme-Beaty E, Stowasser S, Tetzlaff K, Kuwana M, Maher TM; SENSCIS Trial Investigators. N Engl J Med. 2019 Jun 27;380(26):2518-2528.
  7. Metabolic profiling of elite athletes with different cardiovascular demand.Al-Khelaifi F, Donati F, Botrè F, Latiff A, Abraham D, Hingorani A, Georgakopoulos C, Suhre K, Yousri NA, Elrayess MA. Scand J Med Sci Sports. 2019 Jul;29(7):933-943
  8. Endothelial C-Type Natriuretic Peptide Is a Critical Regulator of Angiogenesis and Vascular Remodeling. Bubb KJ, Aubdool AA, Moyes AJ, Lewis S, Drayton JP, Tang O, Mehta V, Zachary IC, Abraham DJ, Tsui J, Hobbs AJ. Circulation. 2019 Mar 26;139(13):1612-1628
  9. Functional and phenotypic heterogeneity of Th17 cells in health and disease. Bystrom J, Clanchy FIL, Taher TE, Al-Bogami M, Ong VH, Abraham DJ, Williams RO, Mageed RA. Eur J Clin Invest. 2019 Jan;49(1):e13032. doi: 10.1111/eci.13032.
  10. Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition.Pereira BI, Devine OP, Vukmanovic-Stejic M, Chambers ES, Subramanian P, Patel N, Virasami A, Sebire NJ, Kinsler V, Valdovinos A, LeSaux CJ, Passos JF, Antoniou A, Rustin MHA, Campisi J, Akbar AN. Nat Commun. 2019 Jun 3;10(1):2387. doi: 10.1038/s41467-019-10335-5
  11. Circulating Senescent T Cells Are Linked to Systemic Inflammation and Lesion Size During Human Cutaneous Leishmaniasis.Covre LP, Martins RF, Devine OP, Chambers ES, Vukmanovic-Stejic M, Silva JA, Dietze R, Rodrigues RR, de Matos Guedes HL, Falqueto A, Akbar AN, Gomes DCO. Front Immunol. 2019 Jan 4;9:3001. doi: 10.3389/fimmu.2018.03001
  12. The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis. Woodcock HV, Eley JD, Guillotin D, Platé M, Nanthakumar CB, Martufi M, Peace S, Joberty G, Poeckel D, Good RB, Taylor AR, Zinn N, Redding M, Forty EJ, Hynds RE, Swanton C, Karsdal M, Maher TM, Bergamini G, Marshall RP, Blanchard AD, Mercer PF, Chambers RC. Nat Commun. 2019 Jan 2;10(1):6. doi: 10.1038/s41467-018-07858-8.
  13. Deciphering the genomic, epigenomic, and transcriptomic landscapes of pre-invasive lung cancer lesions.Teixeira VH, Pipinikas CP, Pennycuick A, Lee-Six H, Chandrasekharan D, Beane J, Morris TJ, Karpathakis A, Feber A, Breeze CE, Ntolios P, Hynds RE, Falzon M, Capitanio A, Carroll B, Durrenberger PF, Hardavella G, Brown JM, Lynch AG, Farmery H, Paul DS, Chambers RC, McGranahan N, Navani N, Thakrar RM, Swanton C, Beck S, George PJ, Spira A, Campbell PJ, Thirlwell C, Janes SM.Nat Med. 2019 Mar;25(3):517-525
  14. Intestinal and hepatic fibrosis: how are they similar? D'Haens G, Pinzani M. Lancet Gastroenterol Hepatol. 2019 Nov;4(11):820-822
  15. Pathophysiology of Organ and Tissue Fibrosis. Parola M,Pinzani M. Mol Aspects Med. 2019 Feb;65:1. doi: 10.1016/j.mam.2019.02.001
  16. Human DEF6 deficiency underlies an immunodeficiency syndrome with systemic autoimmunity and aberrant CTLA-4 homeostasis. Serwas NK, Hoeger B, Ardy RC, Stulz SV, Sui Z, Memaran N, Meeths M, Krolo A, Yüce Petronczki Ö, Pfajfer L, Hou TZ, Halliday N, Santos-Valente E, Kalinichenko A, Kennedy A, Mace EM, Mukherjee M, Tesi B, Schrempf A, Pickl WF, Loizou JI, Kain R, Bidmon-Fliegenschnee B, Schickel JN, Glauzy S, Huemer J, Garncarz W, Salzer E, Pierides I, Bilic I, Thiel J, Priftakis P, Banerjee PP, Förster-Waldl E, Medgyesi D, Huber WD, Orange JS, Meffre E, Sansom DM, Bryceson YT, Altman A, Boztug K. Nat Commun. 2019 Jul 15;10(1):3106. doi: 10.1038/s41467-019-10812-x
  17. Predicting disease outcomes in juvenile idiopathic arthritis: challenges, evidence, and new directions. Shoop-Worrall SJW, Wu Q, Davies R, Hyrich KL, Wedderburn LR. Lancet Child Adolesc Health. 2019 Oct;3(10):725-733
  18. Phenotypic and Functional Characterization of Müller Glia Isolated from Induced Pluripotent Stem Cell-Derived Retinal Organoids: Improvement of Retinal Ganglion Cell Function upon Transplantation. Eastlake K, Wang W, Jayaram H, Murray-Dunning C, Carr AJF, Ramsden CM, Vugler A, Gore K, Clemo N, Stewart M, Coffey P, Khaw PT, Limb GA. stem Cells Transl Med. 2019 Aug;8(8):775-784
  19. Sonic Hedgehog Is a Determinant of γδ T-Cell Differentiation in the Thymus. Mengrelis K, Lau CI, Rowell J, Solanki A, Norris S, Ross S, Ono M, Outram S, Crompton T. Front Immunol. 2019 Jul 19;10:1629.
  20. Sonic Hedgehog signaling limits atopic dermatitis via Gli2-driven immune regulation. Papaioannou E, Yánez DC, Ross S, Lau CI, Solanki A, Chawda MM, Virasami A, Ranz I, Ono M, O'Shaughnessy RFL, Crompton T. J Clin Invest. 2019 Jul 2;129(8):3153-3170.

2018

  1. CTLA-4: a moving target in immunotherapy. Rowshanravan B, Halliday N, Sansom DM. Blood. 2018 Jan 4;131(1):58-67.
  2. MAIT cells are chronically activated in patients with autoimmune liver disease and promote pro-fibrogenic hepatic stellate cell activation. Böttcher K, Rombouts K, Saffioti F, Roccarina D, Rosselli M, Hall A, Luong T, Tsochatzis EA, Thorburn D, Pinzani M. Hepatology. 2018 Jan 12.
  3. Papaioannou I, Xu S, Denton CP, Abraham DJ, Ponticos M. STAT3 controls COL1A2 enhancer activation cooperatively with JunB, regulates type I collagen synthesis  posttranscriptionally, and is essential for lung myofibroblast differentiation. Mol Biol Cell. 2018 Jan 15;29(2):84-95.
  4. Moreno-Moral A, Bagnati M, Koturan S, Ko JH, Fonseca C, Harmston N, Game L, Martin J, Ong V, Abraham DJ, Denton CP, Behmoaras J, Petretto E. Changes in macrophage transcriptome associate with systemic sclerosis and mediate GSDMA contribution to disease risk. Ann Rheum Dis. 2018 Jan 17.
  5. Dritsoula A, Papaioannou I, Guerra SG, Fonseca C, Martin J, Herrick AL, Abraham DJ, Denton CP, Ponticos M. The molecular basis for dysregulated activation of NKX2-5 in vascular remodelling of systemic sclerosis. Arthritis Rheumatol. 2018 Jan 17.
  6. Factors associated with disease progression in early-diagnosed pulmonary arterial hypertension associated with systemic sclerosis: longitudinal data from the DETECT cohort. Mihai C, Antic M, Dobrota R, Bonderman D, Chadha-Boreham H, Coghlan JG,Denton CP, Doelberg M, Grünig E, Khanna D, McLaughlin VV, Müller-Ladner U, Pope JE, Rosenberg DM, Seibold JR, Vonk MC, Distler O. Ann Rheum Dis. 2018 Jan;77(1):128-132.
  7. Human CD8(+) EMRA T cells display a senescence-associated secretory phenotype regulated by p38 MAPK. Callender LA, Carroll EC, Beal RWJ, Chambers ES, Nourshargh S, Akbar AN, Henson SM. Aging Cell. 2018 Feb;17(1).
  8. Development of a consensus core dataset in juvenile dermatomyositis for clinical use to inform research. McCann LJ, Pilkington CA, Huber AM, Ravelli A, Appelbe D, Kirkham JJ, Williamson PR, Aggarwal A, Christopher-Stine L, Constantin T, Feldman BM, Lundberg I, Maillard S, Mathiesen P, Murphy R, Pachman LM, Reed AM, Rider LG, van Royen-Kerkof A, Russo R, Spinty S, Wedderburn LR, Beresford MW. Ann Rheum Dis. 2018 Feb;77(2):241-250.

2017

  1. Pharmacological Inhibition of Bromodomain Proteins Suppresses Retinal Inflammatory Diseaseand Downregulates Retinal Th17 Cells. Eskandarpour M, Alexander R, Adamson P, Calder VL. J Immunol. 2017 Feb 1;198(3):1093-1103.
  2. Riociguat for the treatment of pulmonary arterial hypertension associated with connective tissue disease: results from PATENT-1 and PATENT-2. Humbert M, Coghlan JG, Ghofrani HA, Grimminger F, He JG, Riemekasten G, Vizza CD, Boeckenhoff A, Meier C, de Oliveira Pena J, Denton CP. Ann Rheum Dis. 2017 Feb;76(2):422-426.
  3. Optical coherence tomography evaluation of pulmonary arterial vasculopathy in Systemic Sclerosis. Schwaiger JP, Loder CD, Dobarro D, Kaier T, Reddecliffe S, Schreiber BE, Handler C, Denton CP, Coghlan JG. Sci Rep. 2017 Feb 24;7:43304.
  4. Human regulatory B cells in health and disease: therapeutic potential. Mauri C, Menon M. J Clin Invest. 2017 Mar 1;127(3):772-779.
  5. CD161(+) Tconv and CD161(+) Treg Share a Transcriptional and Functional Phenotype despite Limited Overlap in TCRβ Repertoire. Duurland CL, Brown CC, O'Shaughnessy RF, Wedderburn LR.. Front Immunol. 2017 Mar 6;8:103.
  6. Identifying functional defects in patients with immune dysregulation due to LRBA and CTLA-4 mutations. Hou TZ, Verma N, Wanders J, Kennedy A, Soskic B, Janman D, Halliday N, Rowshanravan B, Worth A, Qasim W, Baxendale H, Stauss H, Seneviratne S, Neth O, Olbrich P, Hambleton S, Arkwright PD, Burns SO, Walker LS, Sansom DM. Blood. 2017 Mar 16;129(11):1458-1468.
  7. A sestrin-dependent Erk-Jnk-p38 MAPK activation complex inhibits immunity during aging. Lanna A, Gomes DC, Muller-Durovic B, McDonnell T, Escors D, Gilroy DW, Lee JH, Karin M, Akbar AN. Nat Immunol. 2017 Mar;18(3):354-363.
  8. Pre/pro-B cells generate macrophage populations during homeostasis and inflammation. Audzevich T, Bashford-Rogers R, Mabbott NA, Frampton D, Freeman TC, Potocnik A, Kellam P, Gilroy DW. Proc Natl Acad Sci U S A. 2017 May 16;114(20):E3954-E3963.
  9. Prostacyclins have no direct inotropic effect on isolated atrial strips from the normal and pressure-overloaded human right heart.  Holmboe S, Andersen A, Jensen RV, Kimose HH, Ilkjær LB, Shen L,Clapp LH, Nielsen-Kudsk JE. Pulm Circ. 2017 Apr-Jun;7(2):339-347.
  10. The fate and lifespan of human monocyte subsets in steady state and systemic inflammation. Patel AA, Zhang Y, Fullerton JN, Boelen L, Rongvaux A, Maini AA, Bigley V, Flavell RA, Gilroy DW, Asquith B, Macallan D, Yona S. J Exp Med. 2017 Jul 3;214(7):1913-1923.
  11. The transcription factor Gli3 promotes B cell development in fetal liver through repression of Shh.  Solanki A, Lau CI, Saldaña JI, Ross S, Crompton T. J Exp Med. 2017 Jul 3;214(7):2041-2058.
  12. Initial combination therapy with ambrisentan and tadalafil in connective tissue disease-associated pulmonary arterial hypertension (CTD-PAH): subgroup analysis from the AMBITION trial. Coghlan JG, Galiè N, Barberà JA, Frost AE, Ghofrani HA, Hoeper MM, Kuwana M, McLaughlin VV, Peacock AJ, Simonneau G, Vachiéry JL, Blair C, Gillies H, Miller KL, Harris JHN, Langley J, Rubin LJ;AMBITION investigators. Ann Rheum Dis. 2017 Jul;76(7):1219-1227.
  13. Surrogate endpoints for clinical trials in non-alcoholic steatohepatitis. Tsochatzis EA, Buzzetti E, Pinzani M. Lancet Gastroenterol Hepatol. 2017 Aug;2(8):549-550.
  14. CD4 T-Cell Dysregulation in Psoriatic Arthritis Reveals a Regulatory Role for IL-22. Ezeonyeji A, Baldwin H, Vukmanovic-Stejic M, Ehrenstein MR. Front Immunol. 2017 Oct 27;8:1403.
  15. Systemic Sclerosis. Denton CP, Khanna D. Lancet. 2017 Oct 7;390(10103):1685-1699.
  16. Defective regulation of autoreactive IL-6-producing transitional B lymphocytes is associated with disease in patients with systemic sclerosis. Taher TE, Ong VH, Bystrom J, Hillion S, Simon Q, Denton CP, Pers JO, Abraham DJ, Mageed RA. Arthritis Rheumatol. 2017 Nov 28.
  17. A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells. Johnston CJC, Smyth DJ, Kodali RB, White MPJ, Harcus Y, Filbey KJ, Hewitson JP, Hinck CS, Ivens A, Kemter AM, Kildemoes AO, Le Bihan T, Soares DC, Anderton SM, Brenn T, Wigmore SJ, Woodcock HV, Chambers RC, Hinck AP, McSorley HJ, Maizels RM. Nat Commun. 2017 Nov 23;8(1):1741.
  18. Acute Respiratory Distress Syndrome. Thompson BT, Chambers RC, Liu KD. N Engl J Med. 2017 Nov 9;377(19):1904-1905.
  19. Fibroblasts and extracellular matrix: Targeting and therapeutic tools in fibrosis and cancer. Prakash J, Pinzani M. Adv Drug Deliv Rev. 2017 Nov 1;121:1-2.

2016

  1. pDC and B regs. Mauri C. Immunity.2016 Mar 15;44 (3):683-97. 
  2. Mediators of inflammatory resolution. Gilroy D. Proc Natl Acad Sci USA. 2016 Jun 7; 113 (23):E3240-9. 
  3. Novel metabolic anti-fibrotics. Dart J. JCI Insight. 2016 Aug 4;1(12):e87001.
  4. Anti-TNF and rheumatoid arthritis. Ehrenstein M. J Exp Med. 2016 Jun 27; 213(7):1241-53. 
  5. Research in paediatric rheumatology. Wedderburn L. Nat Rev Rheumatol. 2016 Nov; 12 (11):684-690). 
  6. Optimizing T-cell receptor gene therapy. Blood. Stauss H. 2016 Jun 30; 127 (26):3305-11. 

2015

  1. Satellite cells from dystrophic muscle retain regenerative capacity. Boldrin L, Zammit PS,Morgan JE. Stem Cell Res.2015 Jan;14(1):20-9.
  2. The transcriptional activator Gli2 modulates T-cell receptor signalling through attenuation of AP-1 and NFκB activity. Furmanski AL, Barbarulo A, Solanki A, Lau CI, Sahni H, Saldana JI, D'Acquisto F, Crompton T. J Cell Sci.2015 Jun 1;128(11):2085-95.
  3. HIF1α allows monocytes to take a breather during sepsis. Gilroy DW, Yona S. Immunity 2015 Mar 17;42(3):397-9.
  4. Metabolic regulation of hepatitis B immunopathology by myeloid-derived suppressor cells. Pallett LJ, Gill US, Quaglia A, Sinclair LV, Jover-Cobos M, Schurich A, Singh KP, Thomas N, Das A, Chen A, Fusai G, Bertoletti A, Cantrell DA, Kennedy PT, Davies NA, Haniffa M, Maini MK. Nat Med.2015 Jun;21(6):591-600. 
  5. Virus-specific T lymphocytes home to the skin during natural dengue infection. Rivino L, Kumaran EA, Thein TL, Too CT, Gan VC, Hanson BJ, Wilder-Smith A, Bertoletti A, Gascoigne NR, Lye DC, Leo YS, Akbar AN, Kemeny DM, MacAry PA. Sci Transl Med.2015 Mar 11;7(278):278ra35.
  6. Regulatory B cells: origin, phenotype, and function. Rosser EC, Mauri C. Immunity 2015 Apr 21;42(4):607-12. 
  7. The p38 mitogen-activated protein kinase cascade modulates T helper type 17 differentiation and functionality in multiple sclerosis. Di Mitri D, Sambucci M, Loiarro M, De Bardi M, Volpe E, Cencioni MT, Gasperini C, Centonze D, Sette C, Akbar AN, Borsellino G, Battistini L. Immunology 2015 Oct;146(2):251-63. 
  8. Endothelial to Mesenchymal Transition Contributes to Endothelial Dysfunction in Pulmonary Arterial Hypertension.  Good RB, Gilbane AJ, Trinder SL, Denton CP, Coghlan G, Abraham DJ, Holmes AM. Am J Pathol. 2015 Jul;185(7):1850-8.
  9. The many faces of type I interferon in systemic lupus erythematosus. Mauri C, Menon M. J Clin Invest. 2015 Jul 1;125(7):2562-4.
  10. Failed degradation of JunB contributes to overproduction of type I collagen and development of dermal fibrosis in patients with systemic sclerosis. Ponticos M, Papaioannou I, Xu S, Holmes AM, Khan K, Denton CP, Bou-Gharios G, Abraham DJ. Arthritis Rheumatol. 2015 Jan;67(1):243-53.
  11. Rod disc renewal occurs by evagination of the ciliary plasma membrane that makes cadherin-based contacts with the inner segment. Burgoyne T, Meschede IP, Burden JJ, Bailly M, Seabra MC, Futter CE. Proc Natl Acad Sci U S A. 2015 Dec 29;112(52):15922-7.
  12. Regulation of neutrophilic inflammation by proteinase-activated receptor 1 during bacterial pulmonary infection. José RJ, Williams AE, Mercer PF, Sulikowski MG, Brown JS, Chambers RC. J Immunol. 2015 Jun 15;194(12):6024-34.
  13. Human corneal stromal stem cells support limbal epithelial cells cultured on RAFT tissue equivalents. Kureshi AK, Dziasko M, Funderburgh JL, Daniels JT. Sci Rep. 2015 Nov 4;5:16186. 
  14. Selexipag for the Treatment of Pulmonary Arterial Hypertension. Sitbon O, Channick R, Chin KM, Frey A, Gaine S, Galiè N, Ghofrani HA, Hoeper MM, Lang IM, Preiss R, Rubin LJ, Di Scala L, Tapson V, Adzerikho I, Liu J, Moiseeva O, Zeng X, Simonneau G, McLaughlin VV; GRIPHON Investigators. N Engl J Med. 2015 Dec 24;373(26):2522-33.
  15. TNFα Regulates SIRT1 Cleavage during Ocular Autoimmune Disease. Gardner PJ, Yazid S, Chu CJ, Copland DA, Adamson P, Dick AD, Calder VL. Am J Pathol. 2015 May;185(5):1324-33.