What is FLARRE

Inflammation, tissue repair, scarring and fibrosis have an essential and important role in the normal biological processes of cells, tissues and organs. They are also involved in some of the most common and severe diseases affecting the general population.

Inflammation

Inflammation occurs as a response to harmful stimuli and often involves the movement of plasma and leukocytes from the blood through the vasculature to the compromised tissue. Chronic inflammation occurs over a period of time and is characterised by a shift in the cell type present at the site of inflammation and by the simultaneous destruction and repair of tissue as a result of the inflammation process. Dysregulation of immune system components or of the inflammatory response cascade can result in disorders such as allergies, autoimmune diseases and some forms of cancer.

Scarring and Fibrosis

Tissue remodeling and scarring is part of the normal repair mechanism. However, a repeated insult or injury can lead to an excessive build-up of fibrotic scar tissue, disrupting tissue and organ function, which can lead to morbidity and mortality. Fibrotic diseases are exhibited in a range of organs, including the lungs, liver, heart, skin and connective tissues.

The FLARRE Consortium seeks to better understand the processes involved in these disorders in order to facilitate the management and treatment of such debilitating conditions.