Ponticos, Markella

Vessel remodeling and Atherosclerosis

Markella Ponticos photo

Markella Ponticos is Senior Research Fellow and Group Leader in the research department of inflammation within UCL Division of Medicine. Her major research interests are the mechanisms that underpin the biology of mesenchymal/stromal cells in normal tissues and their altered differentiation during wound healing, tissue remodelling and in pathology. She is also interested in the transcriptional control mechanism(s) that result in the regulation of extracellular matrix genes in vivo with particular emphasis on the fibroblast, myofibroblast and the smooth muscle cell during vascular remodelling in atherosclerosis and pulmonary arterial hypertension. Her overall objective is to identify the master regulators of tissue remodelling, to unravel mechanisms of disease and develop novel and effective ways to generate effective therapeutics

After her Ph.D in biochemistry at Imperial College London, she received postdoctoral training at the Medical Research Council Clinical Science Centre at the Hammersmith Hospital focusing on signal transduction and kinase specificities, before being appointed as senior research fellow at Centre for Rheumatology and Connective Tissue Diseases, UCL in 1998. In 2005 she became a British Heart Foundation Intermediate Research Fellow, and is a UCL group leader with funding obtained from Arthritis Research UK and the British heart foundation

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Email address: m.ponticos@ucl.ac.uk

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