T-cell Immunity & Ageing
Arne Akbar is an Associate of the Institute of Healthy Ageing, and a Professor of Immunology at UCL. He heads a research group focusing on human T-cell differentiation and longevity and whether end-stage differentiation can lead to the loss of immunity in ageing humans. Achievements include the development of 2- and 3-colour flow-FISH which allows measuring of telomere lengths in different cell populations using flow cytometry, and close collaboration with Celltech plc. resulted in the development of unique reagents, allowing dissection of the complex array of signalling molecules and their roles in CD8+ T cells subsets, specifically those close to end-stage differentiation. His group has developed and validated a new model for the study of a human memory T cell response in vivo and is currently using this model to investigate the causes for defective secondary responses to antigen injection in the skin of older humans.
After his PhD at the University of Southampton, he started his scientific career as a post-doctoral fellow at Sloan Kettering Cancer Centre in New York, followed by two years at Cornell Medical School. He then became a postdoctoral fellow at the Royal Free Hospital Medical School, becoming a Professor in 2000. Since then he has been Head of the research Department of Immunology and is currently Head of Division of infection and Immunity at UCL.
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