Professor Robert Heyderman
Professor of Infectious Diseases and International Health
Research in Professor Heyderman's lab focuses on the acquisition and regulation of naturally acquired immunity to mucosal pathogens of public health importance.
Professor Robert Heyderman is a clinician scientist with skills and experience that bridge clinical practice and fundamental understanding of the mechanisms of infectious disease. He recently moved to UCL after directing the highly successful Malawi-Liverpool-Wellcome Trust Programme (MLW) for over 8 years. This world leading translational research unit that has impacted on the epidemiology, diagnosis, management and prevention of a wide range of life-threatening infections and non-communicable diseases, impacting on both on policy and outcome.
His research focuses on the endothelial biology & coagulopathy of severe infection; the microbial and immunological basis of severe infection by mucosal pathogens and their prevention through vaccination; regulation of host inflammation; and the diagnosis and management of meningitis and sepsis. He has recently launched the NIHR Global Health Research Unit on Mucosal Pathogens (MPRU), which is an interdisciplinary translational programme that brings together internationally recognised UK and African investigators to tackle limitations in the long-term effectiveness of existing vaccines though new approaches to interrupting mucosal pathogen carriage/transmission.
- Molloy SF, Kanyama C, Heyderman RS, Loyse A, Kouanfack C, Chanda D, Mfinanga S, Temfack E, Lakhi S, Lesikari S, Chan AK, Stone N, Kalata N, Karunaharan N, Gaskell K, Peirse M, Ellis J, Chawinga C, Lontsi S, Ndong JG, Bright P, Lupiya D, Chen T, Bradley J, Adams J, van der Horst C, van Oosterhout JJ, Sini V, Mapoure YN, Mwaba P, Bicanic T, Lalloo DG, Wang D, Hosseinipour MC, Lortholary O, Jaffar S, Harrison TS, Team ATS. Antifungal Combinations for Treatment of Cryptococcal Meningitis in Africa. N Engl J Med. 2018;378:1004-17
- Heyderman RS, Madhi SA, French N, Cutland C, Ngwira B, Kayambo D, Mboizi R, Koen A, Jose L, Olugbosi M, Wittke F, Slobod K, Dull PM. Group B streptococcus vaccination in pregnant women with or without HIV in Africa: a non-randomised phase 2, open-label, multicentre trial. Lancet Infect Dis. 2016;16:546-55
- Moxon CA, Wassmer SC, Milner DA, Jr., Chisala NV, Taylor TE, Seydel KB, Molyneux ME, Faragher B, Esmon CT, Downey C, Toh CH, Craig AG, Heyderman RS. Loss of endothelial protein C receptors links coagulation and inflammation to parasite sequestration in cerebral malaria in African children. Blood. 2013;122:842-51
- Kingsley RA, Msefula CL, Thomson NR, Kariuki S, Holt KE, Gordon MA, Harris D, Clarke L, Whitehead S, Sangal V, Marsh K, Achtman M, Molyneux ME, Cormican M, Parkhill J, MacLennan CA, Heyderman RS, Dougan G. Epidemic multiple drug resistant Salmonella Typhimurium causing invasive disease in sub-Saharan Africa have a distinct genotype. Genome Res. 2009;19:2279-87
- Glennie SJ, Banda D, Gould K, Hinds J, Kamngona A, Everett, D, Williams NA, Heyderman RS. Defective pneumococcal-specific Th1 responses in HIV-infected adults precedes a loss of control of pneumococcal colonization. Clin Infect Dis. 2012;56:291-299
- Pido-Lopez J, Kwok W, Mitchell TJ, Heyderman RS, Williams NA. Acquisition of pneumococci specific effector and regulatory Cd4+ T cells localising within human upper respiratory-tract mucosal lymphoid tissue. PloS Pathog. 2011;7:e1002396
- Feasey NA, Gaskell K, Wong V, Msefula C, Selemani G, Kumwenda S, Allain TJ, Mallewa J, Kennedy N, Bennett A, Nyirongo JO, Nyondo PA, Zulu MD, Parkhill J, Dougan G, Gordon MA, Heyderman RS. Rapid emergence of multidrug resistant, h58-lineage salmonella typhi in Blantyre, Malawi. PLoS Negl Trop Dis. 2015;9:e0003748
- Davenport V, Guthrie T, Findlow J, Borrow R, Williams NA, Heyderman RS. Evidence for naturally acquired T cell mediated mucosal immunity to Neisseria meningitidis. J Immunol. 2003;171:4263-7
- Mureithi MW, Finn A, Ota MO, Zhang Q, Davenport V, Mitchell TJ, Williams NA, Adegbola RA, Heyderman RS. T Cell Memory Response to Pneumococcal Protein Antigens in an Area of High Pneumococcal Carriage and Disease. J Infect Dis. 2009;200:783-93
- Clarke ET, Williams NA, Dull PM, Findlow J, Borrow R, Finn A, Heyderman RS. Polysaccharide-protein conjugate vaccination induces antibody production but not sustained B-cell memory in the human nasopharyngeal mucosa. Mucosal Immunol. 2013;6:288-96
- Ho A, Aston SJ, Jary H, Mitchell T, Alaerts M, Menyere M, Mallewa J, Nyirenda M, Everett D, Heyderman RS, French N. Impact of HIV on the burden and severity of influenza illness in Malawian adults: a prospective cohort and parallel case-control study. Clin Infect Dis. 2018;66:865-876
- Anderson ST, Kaforou M, Brent AJ, Wright VJ, Banwell CM, Chagaluka G, Crampin AC, Dockrell HM, French N, Hamilton M, Hibberd ML, Kern K, Langford PR, Ling L, Mlotha R, Ottenhoff THM, Pienaar S, Pillay V, Scott JAG, Twahir H, Wilkinson RJ, Coin LJ, Heyderman RS, Levin M, Eley B on behalf of the ILULU consortium and KIDS TB Study Group. Diagnosis of childhood TB in High TB/HIV burden African countries by host RNA expression. N Engl J Med. 2014;370:1712-23
- Moxon CA, Chisala NV, Wassmer SC, Taylor TE, Seydel KB, Molyneux ME, Faragher B, Kennedy N, Toh CH, Craig AG, Heyderman RS. Persistent endothelial activation and inflammation after Plasmodium falciparum Infection in Malawian children. J Infect Dis. 2014;209:610-5.
A full list of publications can be accessed via Google Scholar.