Professor Benedict Seddon
Reader in Immunology
Research in the Seddon lab focusses on T lymphocyte homeostasis and function.
T lymphocytes are immune cells that play a central role in regulating immune responses. There are several T cell types, all with different functions, so having the right number and composition of these cells is essential for a normal immunity to infection.
The focus of my group is on understanding the molecular and cellular mechanisms that regulate development and maintenance of mature T cells. We have a particular interested in how developing T cells become fully functional and the mechanisms controlling survival and proliferation once full maturity has been attained.
We use mouse genetics to dissect the signalling pathways and molecular mechanisms regulating T cell development and homeostasis. Currently we are focused in the role of NF-kB signalling, as we have identified a key role for this family of transcription factors for the normal development of T cells.
To gain systems level understanding of complex cellular behaviours of the immune system, we have recently established a temporal fate mapping method that allows us to visualise and investigate the processes underlying tonic reconstitution of the immune system throughout the life course of a host. Employing mathematical analysis is key to understanding and interpreting the data from these experiments. We develop mathematical models of key immunological processes that test our understanding, provide novel insights into systems function and generate new hypotheses that can in turn be tested in the laboratory.
- Forker L, Gaunt P, Sioletic S, Shenjere P, Potter R, Roberts D, Irlam J, Valentine H, Hughes D, Hughes A, Billingham L, Grimer R, Seddon B, Choudhury A, Robinson M, West CML. The hypoxia marker CAIX is prognostic in the UK phase III VorteX-Biobank cohort: an important resource for translational research in soft tissue sarcoma. Br J Cancer. 2018;118:698-704
- Seddon B, Strauss SJ, Whelan J, Leahy M, Woll PJ, Cowie F, Rothermundt C, Wood Z, Benson C, Ali N, Marples M, Veal GJ, Jamieson D, Küver K, Tirabosco R, Forsyth S, Nash S, Dehbi HM, Beare S. Gemcitabine and docetaxel versus doxorubicin as first-line treatment in previously untreated advanced unresectable or metastatic soft-tissue sarcomas (GeDDiS): a randomised controlled phase 3 trial. Lancet Oncol. 2017;18:1397-1410
- O'Hara T, Seddon B, O'Connor A, McClean S, Singh B, Iwuoha E, Fuku X, Dempsey E. Quantum Dot Nanotoxicity Investigations Using Human Lung Cells and TOXOR Electrochemical Enzyme Assay Methodology. ACS Sens. 2017;2:165-171
- Loughman T, Singh B, Seddon B, Noone P, Santhosh P. Validation of a membrane touch biosensor for the qualitative detection of IgG class antibodies to herpes simplex virus type 2. Analyst. 2017;142:2725-2734
- Judson I, Bulusu R, Seddon B, Dangoor A, Wong N, Mudan S. UK clinical practice guidelines for the management of gastrointestinal stromal tumours (GIST). Clin Sarcoma Res. 2017;7:6
- Gossel G, Hogan T, Cownden D, Seddon B, Yates AJ. Memory CD4 T cell subsets are kinetically heterogeneous and replenished from naive T cells at high levels. Elife. 2017;6:pii:e23013
- Dangoor A, Seddon B, Gerrand C, Grimer R, Whelan J, Judson I. UK guidelines for the management of soft tissue sarcomas. Clin Sarcoma Res. 2016;6:20
- Ballinger ML, Goode DL, Ray-Coquard I, James PA, Mitchell G, Niedermayr E, Puri A, Schiffman JD, Dite GS, Cipponi A, Maki RG, Brohl AS, Myklebost O, Stratford EW, Lorenz S, Ahn SM, Ahn JH, Kim JE, Shanley S, Beshay V, Randall RL, Judson I, Seddon B, Campbell IG, Young MA, Sarin R, Blay JY, O'Donoghue SI, Thomas DM; International Sarcoma Kindred Study. Monogenic and polygenic determinants of sarcoma risk: an international genetic study. Lancet Oncol. 2016;17:1261-71
- Webb LV, Ley SC, Seddon B. TNF activation of NF-κB is essential for development of single-positive thymocytes. J Exp Med. 2016;213:1399-407
- Foulon S, Brennan B, Gaspar N, Dirksen U, Jeys L, Cassoni A, Claude L, Seddon B, Marec-Berard P, Whelan J, Paulussen M, Streitbuerger A, Oberlin O, Juergens H, Grimer R, Le Deley MC. Can postoperative radiotherapy be omitted in localised standard-risk Ewing sarcoma? An observational study of the Euro-E.W.I.N.G group. Eur J Cancer. 2016;61:128-36.