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Division of Infection and Immunity

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Professor Benedict Seddon

Reader in Immunology

About

Research in the Seddon lab focusses on T lymphocyte homeostasis and function.

Research summary

T lymphocytes are immune cells that play a central role in regulating immune responses. There are several T cell types, all with different functions, so having the right number and composition of these cells is essential for a normal immunity to infection.

The focus of my group is on understanding the molecular and cellular mechanisms that regulate development and maintenance of mature T cells. We have a particular interested in how developing T cells become fully functional and the mechanisms controlling survival and proliferation once full maturity has been attained.

We use mouse genetics to dissect the signalling pathways and molecular mechanisms regulating T cell development and homeostasis. Currently we are focused in the role of NF-kB signalling, as we have identified a key role for this family of transcription factors for the normal development of T cells.

To gain systems level understanding of complex cellular behaviours of the immune system, we have recently established a temporal fate mapping method that allows us to visualise and investigate the processes underlying tonic reconstitution of the immune system throughout the life course of a host. Employing mathematical analysis is key to understanding and interpreting the data from these experiments. We develop mathematical models of key immunological processes that test our understanding, provide novel insights into systems function and generate new hypotheses that can in turn be tested in the laboratory.

Selected publications