Division of Infection and Immunity


IIT External Seminar | Dr David Bending

19 October 2023, 12:00 pm

Event Information

Open to

All | UCL staff | UCL students | UCL alumni


Hanh Gurr


Seminar Room 207
Pears Building

Our next IIT externmal seminar will take place on Thursday 19 October. Dr David Bending from Birmingham University will be speaking on 'Co-receptor regulation of CD4+ T-cell activation'

About the Speaker

Dr David Bending is a T cell immunologist specialising in the regulation of T cell responses and T cell receptor (TCR) signalling. In 2018, he formed his own research group at the University of Birmingham, UK. His lab is supported by  an MRC Career Development award and a 2022 Lister Institute Fellowship prize. Their research focuses on how TCR signalling strength and dynamics regulate T cell function. The lab has keen interests in understanding how co-receptor signals control T cell activation and how phenotypic changes in T cells may be used to understand responses to immunotherapies. A recent major finding is the discovery that the PD-1 pathway is a major player in recalibrating the activation thresholds of CD4+ T cells. Furthermore, blockade of the PD-1 pathway leads to a specific T cell signature of strong TCR signalling, which correlates with survival in melanoma patients on anti-PD-1 immunotherapy.

12pm - Seminar (Pears Building and online via Teams - please contact Hanh Gurr: h.gurr@ucl.ac.uk)

1pm - Lunch with trainees

5pm - Drinks reception 

  • Please contact host Prof. Lucy Walker (lucy.walker@ucl.ac.uk) and Hanh Gurr (h.gurr@ucl.ac.uk) to organise one-to-one meetings with Dr. Bending between 2pm and 5pm.