Division of Infection and Immunity


IIT Seminar | Dr Constandina Pospori

10 June 2021, 12:00 pm–1:00 pm

'AML vs T cells, what tilts the balance – and can we tamper the scale to achieve cure?'

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Dr Anne Pesenacker

Dr Constandina Pospori (Imperial College London) will be speaking at the UCL Institute of Immunity and Transplantation Seminar Series on Thursday 10 June.

All are welcome to attend. Please contact Fran Jackson (f.jackson@ucl.ac.uk) if you would like to join the seminar, or meet the speaker.

About the speaker

Dr Constandina Pospori took her PhD in Tumour Immunology in the Morris and Stauss lab, in one of the first cohorts of the UCL MB PhD programme. In her PhD she showed that specificity for the WT1 tumour-associated, self-antigen, can drive the development of fully functional memory T cells in the absence of vaccination. She then moved from UCL to Imperial College, to focus her postdoctoral training on bone marrow (BM) biology, first with a short postdoc on BM mesenchymal stromal cells with Prof. Rankin, and subsequently with Professor Lo Celso for her senior postdoc investigating the interactions between Acute Myeloid Leukaemia (AML) and T cells.

In her seminar, she will present her recent work showing that the dynamic regulation of hierarchical heterogeneity in AML can serve as a tumour immunoevasion mechanism. Dina’s expertise now bridges the fields of tumour immunology and BM biology in the context of haematological malignancies. In her independent research career, she aims to establish an interdisciplinary approach spanning murine in vivo models, mathematical modelling and human sample analysis, to better define the therapeutic T cell niche and elucidate how this is remodelled in haematological and solid malignancies. The overarching aim of this work will be to identify targetable parameters to restore the T cell supportive function of the BM microenvironment to improve T cell immunotherapy outcomes.

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