Division of Infection and Immunity


IIT Seminar | Dr James Thaventhiran

11 July 2019, 12:00 pm–1:00 pm

'Learning about immune checkpoints in rare patients in mice'

Event Information

Open to



Dr Siobhan Burns (Host)


Lecture Theatre 3
UCL Medical School, Royal Free Campus
Rowland Hill Street
United Kingdom

Dr James Thaventhiran of the Department of Medicine at the University of Cambridge will be speaking at the UCL Institute of Immunity and Transplantation Seminar Series on Thursday 11 July. The seminar will be held in Lecture Theatre 3 at the UCL Medical School Royal Free Campus.

All are welcome to attend. If you would like to meet the speaker after the seminar please contact the host or Mahdia Sait (m.sait@ucl.ac.uk).

About the speaker

The adaptive immune system depends on the vast proliferation of anti-pathogen lymphocytes. In order to proliferate in this way, lymphocytes have to maintain their replicative capacity in the face of anti-proliferative signals delivered by inflammation. Dr Thaventhiran's prior work has studied how the signal for terminal differentiation in these cells could be linked to the magnitude of their proliferation.

Dr Thaventhiran's current focus is the study of how responding adaptive immune lymphocytes avoid the anti-proliferative signals of inflammation. This work has received substantial support from the MRC and hopes to identify new pathways for the therapeutic manipulation of immune responses. These scientific objectives stem directly from Dr Thaventhiran's clinical work, based at Addenbrooke’s hospital, where I look after patients with primary and secondary immunodeficiency. An ongoing research priority within our clinical department is the identification of novel immunodeficiencies and therapies.

Further information

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