Division of Infection and Immunity


IIT Seminar | Dr David Thomas

10 January 2019, 12:00 pm–1:00 pm

'EROS mutations: Chronic Granulomatous Disease and More'

Event Information

Open to



Professor Emma Morris (Host)


Lecture Theatre 3
UCL Medical School, Royal Free Campus
Rowland Hill Street
United Kingdom

Dr David Thomas of the University of Cambridge Department of Medicine will be speaking at the UCL Institute of Immunity and Transplantation Seminar Series on Thursday 10 January. The seminar will be held in Lecture Theatre 3 at the UCL Medical School Royal Free Campus.

David Thomas has characterised a gene, Eros (Essential for Reactive Oxygen Species).  Eros is essential for our immune system to kill harmful bacteria such as Salmonella.  This is because the protein encoded by the Eros gene is needed for the stability of a complex of proteins called NADPH oxidase, which generates chemicals such as hydrogen peroxide to kill bacteria and fungi: Without Eros, this process cannot occur.  Eros also controls other important processes within the immune system, unrelated to its effects on the NADPH oxidase.  His group is investigating exactly why Eros has these diverse effects by using biochemical techniques to dissect what happens in its absence in different cell types.  This will give new and important information about how the immune system defends itself against harmful pathogens.

All are welcome to attend. If you would like to meet the speaker after the seminar please contact the host.

Further information