CALIBER

CALIBER - Clinical disease research using LInked Bespoke studies and Electronic health Records

Our Research

By providing a complete picture of patients’ health care utilisation and deep longitudinal phenotyping, CALIBER has become a leading research platform for the understanding of health progression, from onset of early stages to the development of significant functional impairment. The platform links electronic health records from primary care, coded hospital records on diagnoses and operations, social deprivation information and cause-specific mortality data in England for roughly 2 million adults. An online Data Portal contains disease and risk factor phenotyping algorithms for the wider scientific community to use.

Themes

• Discovery science
• Public health
• Learning health systems
• Precision medicine
• Data analytics
• Information governance

Diseases

• Cardiovascular disease
• Mental and behavioural disorders
• Cancer
• Autoimmune disease

Methods 

• Deep phenotyping
• Data linkage 
• Statistical analysis of episodic longitudinal data
• Machine learning approaches

People

• Spiros Denaxas
• Natalie Fitzpatrick 
• Arturo Gonzalez-Izquierdo
• Harry Hemingway

Collaborators

• Liam Smeeth
• Adam Timmis

Publications

Denaxas S.C. et al. Data Resource Profile: Cardiovascular disease research using linked bespoke studies and electronic health records (CALIBER). Int. J. Epidemiol 2012; 41:1625–1638. doi: 10.1093/ije/dys188.