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2017

Allan V, Honarbakhsh S, Casas J-P,  Wallace J, Hunter R, Schilling R, Perel P, Morley K, Banerjee A, Hemingway H. Are cardiovascular risk factors also associated with the incidence of atrial fibrillation? Thrombosis and Haemostasis 2017. doi: https://doi.org/10.1160/TH16-11-0825.

Bell S, Daskalopoulou M, Rapsomaniki E, George J, Britton A, Bobak M, Casas J-P, Dale C, Denaxas S, Shah A, Hemingway H. Association of clinically recorded alcohol consumption with the initial presentation of twelve cardiovascular diseases: a population-based cohort study using linked health records. BMJ 2017;356:j909; doi: https://doi.org/10.1136/bmj.j909 (Published 22 March 2017).

Hemingway H, Feder G.S., Fitzpatrick NK, Denaxas S, Shah AD, Timmis AD. Using nationwide ‘big data’ from linked electronic health records to help improve outcomes in cardiovascular diseases: 33 studies using methods from epidemiology, informatics, economics and social science in the ClinicAl disease research using LInked Bespoke studies and Electronic health Records (CALIBER) programme. Programme Grants Appl Res 2017 (Feb);5(4). doi: 10.3310/pgfar05040.

Jordan KP, Timmis A, Croft P, van der Windt D, Denaxas S, Gozalez-Izquierdo A, Hayward RA, Perel P, Hemingway H.  Prognosis of undiagnosed chest pain: a linked electronic health record cohort study. BMJ (in press).

Pasea L, Chung S-C, Pujades-Rodriguez M, Moayyeri A, Fox KAA, Wallentin L, Pocock SJ, Timmis A, Banerjee A, Patel R, Hemingway H. Personalising the decision for prolonged dual antiplatelet therapy: Development, validation and potential impact of prognostic models for cardiovascular events and bleeding in myocardial infarction survivors. European Heart Journal 2017 (in press).

Poppe KK, Doughty RN, Wells S, Gentles D, Hemingway H, Jackson R, Lerr AJ. Developing and validating a cardiovascular risk score for patients in the community with prior cardiovascular disease. Heart Published Online First: 23 February 2017. doi: 10.1136/heartjnl-2016-310668.

Shah AD, Denaxas S, Nicholas O, Hingorani AD, Hemingway H. Neutrophil counts and initial presentation of 12 cardiovascular diseases: a CALIBER cohort study. JACC 2017; 69(9):1160–9. doi: 10.1016/j.jacc.2016.12.022.

Shah AD, Thornley S, Chung S-C, Denaxas S, Jackson R, Hemingway H. White cell count in the normal range and short and long term mortality: international comparisons of electronic health record cohorts in England and New Zealand. BMJ Open 2017; 7(2):e013100, 17 Feb 2017. doi: 10.1136/bmjopen-2016-013100

2016

Allan V, Banerjee A, Shah AD, Patel R, Denaxas S, Casas J-P, Hemingway H. Net clinical benefit of warfarin in individuals with atrial fibrillation across stroke risk and across primary and secondary care. Heart Online First, published on August 31, 2016. doi 10.1136/heartjnl-2016-309910.

Asaria, M A, Walker S, Palmer, S, Gale C, Shah A, Abrams K Crowther M, Manca A, Timmis A, Hemingway H, Sculpher M. Using electronic health records to predict costs and outcomes in stable coronary artery disease. Heart 2016 Feb 10. pii: heartjnl-2015 308850. doi: 10.1136/heartjnl-2015-308850. [Epub ahead of print]

Daskalopoulou M, George J, Walters K, Osborn DP, Batty GD, Stogiannis D, Rapsomaniki E, Pujades-Rodriguez M, Denaxas S, Udumyan R, Kivimaki M, Hemingway H. Depression as a risk factor for the initial presentation of twelve cardiac, cerebrovascular, and peripheral arterial diseases: data linkage study of 1.9 million women and men. PLOS ONE 2016; April 22. doi: 10.1371/journal.pone.0153838

Pujades-Rodriguez M, Duyx B, Thomas S L, Stogiannis D, Smeeth S, Hemingway H. Associations between polymyalgia rheumatica and giant cell arteritis and 12 cardiovascular diseases. Heart 2016; 102(5):383-9, published online 9 Jan. doi:10.1136/heartjnl-2015-308514

Pujades-Rodriguez M, Duyx B, Thomas SL, Stogiannis D, Rahman A, Smeeth L, Hemingway H. Rheumatoid arthritis and incidence of twelve initial presentations of cardiovascular disease: a population record-linkage cohort study in England. PLOS ONE 2016; March 15. doi: 10.1371/journal.pone.0151245

Rothnie KJ, Smeeth L, Pearce N, Herrett E, Timmis A, Hemingway H, Wedzicha J, Quint JK. Predicting mortality after acute coronary syndromes in people with chronic obstructive pulmonary disease. Heart 2016. Published online May, 13. doi:10.1136/heartjnl-2016-309359.

Sekhri N, Perel P, Clayton T, Feder GS, Hemingway H, Timmis A. R1 - A 10-year prognostic model for patients with suspected angina attending a chest pain clinic. Heart 2016;0:1–7. doi:10.1136/heartjnl-2015-308994.

Shah AD, Denaxas S, Nicholas O, Hingorani AD, Hemingway H. Low eosinophil and low lymphocyte counts and the incidence of 12 cardiovascular diseases: a CALIBER cohort study. Open Heart. 2016; 3(2): e000477. doi: 10.1136/openhrt-2016-000477

Timmis A, Rapsomaniki E, Chung S-C, Pujades-Rodriguez, M, Moayyeri A, Stogiannis D, Shah AD, Pasea L, Denaxas S, Emmas C, Hemingway H. Prolonged dual antiplatelet therapy in stable coronary disease: comparative observational study of benefits and harms in unselected versus trial populations. BMJ 2016;353:i3163. doi:http://dx.doi.org/10.1136/bmj.i3163 (Published 22 June 2016)

Walker S, Asaria M, Manca A, Palmer S, Gale CP, Shah AD,  Abrams K,  Crowther M, Timmis A,  Hemingway H,  Sculpher S. Long term health care use and costs in patients with stable coronary artery disease: a population based cohort using linked health records (CALIBER). EHJ: QCCO 2016; published online 20 Jan. doi:10.1093/ehjqcco/qcw003

2015

Brauer  R,  Smeeth  L,  Anaya-Izquierdo  K,  Timmis  A,  Denaxas  SC,  Farrington  CP, Whitaker  H,  Hemingway  H,  Douglas  I.  Antipsychotic  drugs  and  risks  of  myocardial infarction:  a  self-controlled  case  series  study.  Eur  Heart  J  2015;  015  Apr 21;36(16):984-92.  doi:  10.1093/eurheartj/ehu263.

Chung  S-C,  Sundström  J,  Gale  CP,  James  S,  Deanfield  J,  Wallentin  L,  Timmis  A, Jernberg  T,  Hemingway  H.  Comparison  of  hospital  variation  in  acute  myocardial infarction  care  and  outcome  between  Sweden  and  United  Kingdom:  population based  cohort  study  using  nationwide  clinical  registries.  BMJ  2015;351:h3913. [Epub  ahead  of  print].  doi:  http://dx.doi.org/10.1136/bmj.h3913

George  J,  Rapsomaniki  E,  Pujades-Rodriguez  M,  Shah  AD,   Denaxas  S,  Herrett  E, Smeeth  L,  Timmis  A,  Hemingway  H. How  Does  Cardiovascular  Disease  First  Present in  Women  and  Men?  Incidence  of  12  Cardiovascular  Diseases  in  a  Contemporary Cohort  of  1,937,360  People.  Circulation  2015;  132: 1320–8. doi:10.1161/CIRCULATIONAHA.114.013797.  

Rothnie  KJ,  Smeeth  L,  Herrett  E,  Pearce  N,  Hemingway  H, Wedzicha  J,  Timmis  A, Quint  JK.  Closing  the  mortality  gap  after  a  myocardial  infarction  in  people  with and  without  chronic obstructive  pulmonary  disease.  Heart  2015;  Published  Online First:13  Mar.  doi:10.1136/heartjnl-2014-307251

2014

Chung  S-C,   Gedeborg  R,  Nicholas  O,  James  S,   Jeppson  A,  Wolfe  C, Heuschmann P,   Wallentin  L,   Deanfield  J,   Timmis  T,   Jernberg  T,     Hemingway  H.  Acute myocardial  infarction:  a  comparison  of  short-term  survival  in  national  outcome registries  in  Sweden  and  the  UK.  The  Lancet  2014;  383(9925):1305-12.  doi: 10.1016/S0140-6736(13)62070-X

Herrett  E,  Bhaskaran  K,  Timmis  A,  Denaxas  S,  Hemingway  H,  Smeeth  L. Association  between  clinical  presentations  before  myocardial  infarction  and  coronary mortality:  a  prospective  population-based  study  using  linked  electronic  records. Eur Heart  J  2014;  35(35):2363-71.  doi:10.1093/eurheartj/ehu286

Morley  KI,  Wallace  J,  Denaxas  SC,  Hunter  RJ,  Patel  RS,  Perel  P ... Hemingway H. Defining  disease  phenotypes  using  national  linked  electronic  health records:  a  case study  of  atrial  fibrillation.  PLoS  One  2014;  9(11):e110900-. doi:10.1371/journal.pone.0110900

Pujades-Rodriguez  M,  George  J,  Shah  AD,  Rapsomaniki  E,  Denaxas  S,  West  R  ... Hemingway  H.  Heterogeneous  associations  between  smoking  and  a  wide  range  of initial  presentations  of  cardiovascular  disease  in  1 937 360  people  in  England: lifetime  risks  and  implications  for  risk  prediction.  Int  J  Epidemiol  2014;  Nov  20. [Epub  ahead  of  print].  doi:10.1093/ije/dyu218

Pujades-Rodriguez, Timmis A, Stogiannis D, Rapsomaniki E, Denaxas S, Shah A, Feder G, Kivimaki M, Harry Hemingway H. Socioeconomic Deprivation and the Incidence of 12 Cardiovascular Diseases in 1.9 Million Women and Men: Implications for Risk Prediction and Prevention. PLoSOne 2014; 9(8): e104671. doi: 10.1371/journal.pone.0104671

Rapsomaniki  E,  Timmis  A,  George  J,  Pujades-Rodriguez  M,  Shah  AD,  Denaxas  S, White  IR,  Caulfield  MJ,  Deanfield  JE,  Smeeth  L,  Williams  B,  Hingorani  A, Hemingway  H.  Blood  pressure  and  incidence  of  twelve  cardiovascular  diseases: lifetime  risks,  healthy  life-years  lost,  and age-specific  associations  in  1·25  million people.  The  Lancet  2014;  383(9932):1899  –911.  doi: 10.1016/S0140-6736(14)60685-1.

Shah  AD,  Bartlett  JW,  Carpenter  J,  Nicholas  O,  Hemingway  H. Comparison  of random  forest  and  parametric  imputation  models  for  imputing  missing  data  using MICE:  a  CALIBER  study.  Am  J  Epidemiol.  2014;  Mar  15;179(6):764-74. doi: 10.1093/aje/kwt312.  Epub  2014  Jan  12.

Shah  AD,  Bartlett  J,  Hemingway  H,  Nicholas  O,  Hingorani  H.  CALIBERrfimpute: Imputation  in  MICE  using  Random  Forest  (Version  0.1-6)  [Software].  2014. Online:  Comprehensive  R  Archive  Network. https://cran.r-project.org/web/packages/CALIBERrfimpute/index.html

Shah  AD,  Langenberg  C,  Rapsomaniki  E,  Denaxas  S,  Pujades-Rodriguez  M,  Gale CP,  Deanfield  J,  Smeeth  L,  Timmis  A,  Hemingway  H.  Type  2  diabetes  and incidence  of  cardiovascular  diseases:  a  cohort  study  in  1·9  million  people.  Lancet Diabetes  Endocrinol  2014;  Nov  11.  pii:  S2213-8587(14)70219-0.  [Epub  ahead  of print].  doi:  10.1016/S2213-8587(14)70219-0.  

2013

Herrett  E,  George  J,  Denaxas  S,  Timmis  AD,  Hemingway  H,  Smeeth  L.  Type  and timing  of  heralding  in  ST-elevation  and  non-ST-elevation  myocardial  infarction:  an analysis  of  prospectively  collected  electronic  healthcare  records  linked  to  the national  registry  of  acute  coronary  syndromes.  European  Heart  Journal  –  Acute Cardiac  Care  (ACC)  2013:  2(3):235–45.  doi:10.1177/2048872613487495

Herrett  E,  Shah  AD,  Boggon  R,  Denaxas  S,  Smeeth  L,  van  Staa  T,  Timmis  A, Hemingway  H.  Completeness  and  diagnostic  validity  of  recording  acute  myocardial infarction  events  in  primary  care,  hospital  care,  disease  registry,  and  national mortality  records:  cohort  study.  BMJ  2013;  346:f2350.  doi:10.1136/bmj.f2350

Quint,  J.  K.,  Herrett,  E.,  Bhaskaran,  K.,  Timmis,  A.,  Hemingway,  H.,  Wedzicha,  J. A.,  &  Smeeth  L.  Effect  of  β  blockers  on  mortality  after  myocardial  infarction  in adults  with  COPD:  population  based  cohort  study  of  UK  electronic  healthcare records.  BMJ  2013;  Nov  22;347:f6650.  doi: 10.1136/bmj.f6650.

Rapsomaniki  E,  Shah  A,  Perel  P,  Denaxas  S,  George  J,  Nicholas  O,  Udumyan  R, Feder  GS,  Hingorani  AD,  Timmis  A,  Smeeth  L,  Hemingway  H.  Prognostic  models for  stable  coronary  artery  disease  based  on  electronic  health  record  cohort  of  102 023  patients.  Eur  Heart  J.  2013  Dec  17. doi:10.1093/eurheartj/eht533 [Epub ahead  of  print]

Shah,  A.  D.,  Herrett,  E.,  Boggon,  R.,  Denaxas,  S.,  Smeeth,  L.,  van  Staa,  T.,  .  .  . Hemingway,  H.  Accuracy  of  recording  acute  myocardial  infarction  events.  Authors' reply  to  Stevens  and  McManus.  BMJ  2013;346.  doi:10.1136/bmj.f3741

2012

Boggon  R,  Timmis  A,  Hemingway  H,  Raju  S,  Malvestiti  FM,  Van  Staa  TP.  Smoking cessation  interventions  following  acute  coronary  syndrome:  a  missed  opportunity? Eur  J  Prev  Cardiol  2012  Sept  5;21(6):767–73. doi: 10.1177/2047487312460517.

Denaxas  SC,  George  J,  Herrett  E,  Shah  AD,  Kalra  D,  Hingorani  AD,  Hemingway H. Data  Resource  Profile:  Cardiovascular  disease  research  using  linked  bespoke  studies and  electronic  health  records  (CALIBER).  Int  J  Epidemiol  2012;  41  (6),  1625–38. doi:10.1093/ije/dys188.

Douglas  IJ,  Evans  SJW,  Hingorani  AD,  Grosso  AM,  Timmis  A,  Hemingway  H, Smeeth  L.  Clopidogrel  and  interaction  with  proton  pump  inhibitors:  comparison between  cohort  and  within  person  study  designs.  BMJ  2012;  345,  e4388–e4388. doi: 10.1136/bmj.e4388.

Shah  AD,  Martinez  C,  Hemingway  H.  The  Freetext  Matching  Algorithm:  a computer program  to  extract  diagnoses  and  causes  of  death  from  unstructured  text  in electronic  health  records.  BMC  Medical  Informatics  and  Decision  Making  2012; 12(88). doi: 10.1186/1472-6947-12-88.

Wang  Z,  Shah  AD,  Tate  AR,  Denaxas  S,  Shawe-Taylor  J,  Hemingway  H. Extracting diagnoses  and  investigation  results  from  unstructured  text  in  electronic  health records  by  semi-supervised  machine  learning.  (V.  Brusic,  Ed.)  PLoS  ONE  2012; 7(1),  e30412.  doi: http://dx.doi.org/10.1371/journal.pone.0030412.

Warren-Gash  C,  Hayward  AC,  Hemingway  H,  Denaxas  S,  Thomas  SL,  Timmis  AD et  al.  Influenza  Infection  And  Risk  of  Acute  Myocardial  Infarction  in  England  & Wales:  A  CALIBER  Self-Controlled  Case  Series  Study.  Journal  of  Infectious Diseases 2012  Dec;  206(11):  1652–9. doi: 10.1093/infdis/jis597.

2011

Boggon  R,  van  Staa  TP,  Timmis  A,  Hemingway  H,  Ray  KK,  Begg  A,  Emmas  C  et al.  Clopidogrel  discontinuation  after  acute  coronary  syndromes:  frequency, predictors  and associations  with  death  and  myocardial  infarction--a  hospital registry-primary  care linked  cohort  (MINAP-GPRD).  Eur  Heart  J  2011;  32(1522–9645 (Electronic)), 2376–86. doi: 10.1093/eurheartj/ehr340.

Shah  AD,  Nicholas  O,  Timmis  AD,  Feder  G,  Abrams  KR,  Chen  R,  Hingorani  AD, Hemingway  H.  Threshold  haemoglobin  levels  and  the  prognosis  of  stable  coronary disease:  two  new  cohorts  and  a  systematic  review  and  meta-analysis.  PLoS  Med 2011  May;  8(5):  e1000439. doi: http://dx.doi.org/10.1371/journal.pmed.1000439. Epub  2011  May  31.