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CALIBER

CALIBER is a unique research platform consisting of ‘research ready’ variables extracted from linked electronic health records (EHR) from primary care, coded hospital records, social deprivation information and cause-specific mortality data in England.

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Led from the UCL Institute of Health Informatics, CALIBER enables researchers to recreate the longitudinal journey of patients (‘from cradle to the grave’) through care pathways to study disease onset and progression. Our aim is to foster an open community developing methods and tools to accelerate replicable science across all clinical and scientific disciplines spanning the translational cycle (from drug discovery through to public health).

The resource consists of ‘research ready’ variables extracted from linked NHS electronic health records and administrative health data, for more than 10 million adults with 400 million person-years of follow-up.

 

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10m people, 400m person years follow-up

Data sources

Our main data provider is the Clinical Practice Research Datalink (CPRD), which collects data of primary care activity and links to secondary care (Hospital Episode Statistics inpatient, outpatient, A&E and diagnostic imaging dataset data) and national registry social deprivation and mortality data from the Office for National Statistics are available for research:

  • General practice, hospital inpatient, outpatient and A&E data and mortality data up to March 2016
  • Diagnoses of all diseases including rare Mendelian and syndromes
  • Clinical examination findings (e.g. blood pressure, weight, height) 
  • Blood laboratory results
  • Prescriptions and vaccinations
  • Primary care consultations and hospitalisations
  • Cause of death

Methods and Tools

  • Structured approach to develop and validate phenotyping algorithms
  • Central online repository for the storage and distribution of algorithms, documentation and metadata

Specialised Infrastructure 

  • ISO27001 compliant data safe haven environment 
  • High performance computing platforms to support computationally intensive research 

Training and Support

  • Specialist training to equip researchers with the skills and knowledge to code and analyse large, linked datasets
  • Data safe haven and information governance

CALIBER operates a collaboration-driven data sharing platform and prioritises collaborations based on scientific-added value, capacity development and sustainable funding. Access to CPRD data on the CALIBER platform to facilitate collaboration with academic, National Health Service and commercial partners follows CPRD’s data access governance policies. The CALIBER platform can support researchers from development of research proposals through to release of CPRD data in the CALIBER data safe haven.

Click below for details about the CALIBER platform and access to the data portal and tools

Data Resource Profile
Information about the CALIBER platform
Data Portal
Electronic health record phenotyping algorithms
Tools
Tools and scripts for manipulating electronic health records
 

CALIBER has research ethics approval (09/H0810/16) and ECC approval (ECC 2-06(b)/2009 CALIBER dataset) and initial funding was provided by the Wellcome Trust (086091/Z/08/Z) and the National Institute for Health Research (RP-PG-0407- 10314).

 

Data lab

Data Lab

At the intersection of clinical research and computer science, the Data Lab seeks to develop data-driven computational methods and tools for exploiting electronic health records for biomedical research.

Projects

Projects

By providing a complete picture of patients’ health care utilisation and deep longitudinal phenotyping, CALIBER has become a leading research platform for the understanding of health progression.

CALIBER data

CALIBER resources

Frequently asked questions on who can use CALIBER, how to apply to use the CALIBER resource, fees and capacity building.

Materials

Materials

Resources, including sample ISAC application forms, agreements and forms are available to guide researchers through the application process.

Contact and support

Contact and support

Information about the CALIBER resource, fees and support, or to discuss potential collaboration for specific enquiries about existing CALIBER projects.

Publications

Publications

A full list of publications using CALIBER data.