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UCL Ear Institute

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Linden Lab

Our research aim is to understand brain mechanisms of listening. More specifically, we seek to understand how complex, temporally varying sounds (such as speech) are represented and analyzed by neurons in the auditory cortex and thalamus. We also study how brain mechanisms of listening are disrupted in mouse models of human schizophrenia, tinnitus and auditory processing disorder. Our goal is to translate fundamental discoveries in mice into new tools and treatments for improving listening ability in humans. Experimental methods include electrophysiological recording, computational modelling, histological analysis, and auditory behavioral testing.

We are grateful to have received funding for past projects from the Medical Research Council (MRC), the Biotechnology and Biological Sciences Research Council (BBSRC), the Wellcome Trust, the Royal National Institute for Deaf People (RNID, formerly Action on Hearing Loss), the Royal Society, and the Gatsby Charitable Foundation Trust. Currently, our research on fundamental brain mechanisms of listening is funded by the BBSRC, and our translational work on development of new algorithms to improve human listening ability is funded by the UCL Therapeutic Acceleration Support Fund and the UCL NIHR Biomedical Research Deafness and Hearing Problems Theme. See Projects for further details.

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