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Stable Isotope Labeling Kinetics (SILK) is a method for quantitating protein and lipids turnover in human cell models and in vivo. We use this method to a) interrogate disease mechanisms and b) measure treatment responses across a range of neurodegenerative diseases, with a focus on early phase clinical trials.
- SILK Publications
The below is a depiction of stable isotope labelling kinetics (SILK) methodology and was published in Paterson et al. 2019. The full article can be accessed here.
Paterson RW, Gabelle A, Lucey BP, Barthelemy NR, Leckey CA, Hirtz C, Lehmann S, Sato C, Patterson BW, West T, Yarasheski K, Rohrer JD, Wildburger NC, Schott JM, Karch CM, Wray S, Miller TM, Elbert DL, Zetterberg H, Fox NC, Bateman RJ. SILK studies - capturing the turnover of proteins linked to neurodegenerative diseases. Nat Rev Neurol. 2019 July; 15(7):419-427. doi:10.1038/s41582-019-0222-0.
- SILK Team
- Ross Paterson, PI and Principal Clinical Research Fellow
- Tatiana Alvarez Giovannucci, Research Fellow
- Claire Leckey, Research Fellow
- Aram Aslanyan, Clinical Research Fellow
- Eleanor Moncur, Clinical Research Fellow