Close
DOLPHIN-UK
Developmental Optimisation using Lavage in Preterm Haemorrhage in Infants in the UK: A national randomised controlled trial on the efficacy of neuro-endoscopic lavage
18 July 2023
 |
DOLPHIN-UK is a phase-III, multicentre, randomised, assessor-blinded, controlled trial of Neuroendoscopic levage (NEL) with temporising device (intervention arm) vs temporising device alone (standard treatment arm) in preterm infants with intraventricular haemorrhaging and post-haemorrhagic ventricular dilatation with an internal pilot study.
Status: Set up
Funder: National Institute for Health and Care Research (NIHR HTA)
ISRCTN: Registration in progress
Chief investigator: Mr. Kristian Aquilina, Consultant Paediatric Neurosurgeon (Great Ormond Street Hospital)
Heath condition: Post-haemorrhagic hydrocephalus
Intervention: Neuroendoscopic levage (NEL) with temporising device
Control: Temporising device alone
Key outcomes: Cognitive quotient (CQ) at 2 years corrected age as measured by the Bayley Scales of Infant and Toddler Development (fourth edition)
Setting: Paediatric neurosurgical units
Duration: 72 months (participants involved from pre-term birth through ~2 years old)
Target date for first enrolment: September 2023
Target sample size: 100
Target sites: 13