Early phase dose-finding clinical trials: online course
12 February 2021–19 February 2021, 2:00 pm–6:00 pm
Taking place over two afternoons (12 and 19 February), the aim of this course is to provide a solid grounding in the current methodology of early phase dose-finding clinical trials
Hakim-Moulay Dehbi – Comprehensive Clinical Trials Unit at UCL
We have produced a short introductory video about the course and the presenters below:
This online course is aimed at trial statisticians and clinicians who want to understand more and increase their theoretical and applied understanding of early phase dose-finding trials, or those who are new to the area.
Short educational videos will be made available prior to the course, so that attendees can refresh their knowledge in advance, and also send questions so that they can be addressed during the live course.
The online course aims to help participants:
- understand the motivation behind model-based designs such as the Continual Reassessment Method
- learn more about the intricacies of the designs, such as the skeleton and how to run/interpret simulations to assess operating characteristics
- learn more about the statistical theory behind dose-finding trials (convergence, coherence principles, optimal designs)
- learn more about dose expansion cohorts
- learn about more complex design with patient heterogeneity, and bridging trials
- learn about existing softwares and how to develop the statistical section of a dose-finding protocol
Structure of the online course:
The two afternoons will comprise live lectures, quizzes and dedicated times for questions from the attendees.
Educational videos will be made available prior to the course so that attendees can learn or refresh their knowledge on all the topics that will be covered during the course.