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A list of current and completed trials in CCTU can be seen below.
Current Trials
| Trial Name | Title | Research Area | Trial Registry ID |
|---|---|---|---|
| ADEPT-PD | Antidepressants in Parkinson's Disease. | ISRCTN48548553 | |
| ASEPTIC | Primary Antibiotic prophylaxis using co-trimoxazole to prevent SpontanEous bacterial PeritoniTIs in Cirrhosis. | ISRCTN33225996 | |
ASPro-PD | Ambroxol to Slow Progression in Parkinson Disease: A phase III multi-centre randomised placebo-controlled trial. | Pending | |
| COG-UK HOCI | A phase III prospective, interventional, cohort, superiority study to evaluate the benefit of rapid COVID-19 genomic sequencing (the COVID-19 GENOMICS UK project) on infection control in preventing the spread of the virus in United Kingdom NHS settings. | ISRCTN50212645 | |
| DOLPHIN | Developmental Optimisation using Lavage in Preterm Haemorrhage in Infants in the UK: A national randomised controlled trial on the efficacy of neuro-endoscopic lavage. | Registration in progress | |
| EXENATIDE-PD3 | A randomised, double blind, parallel group, placebo controlled Phase 3 trial of Exenatide once weekly over 2 years as a potential disease modifying treatment for Parkinson's disease. | ISRCTN14552789 | |
| HORACE | Phase I/II open label, multicentre clinical trial to assess the safety and efficacy of ssAAV-LK03.hAAT.hcoOTC (Gene Therapy) for paediatric patients with ornithine transcarbamylase deficiency. | Registration in progress | |
| METRIC | Magnetic resonance Enterography (MRE) or ulTRasound In Crohn’s disease Extended Follow-up for predicting disabling disease. | ISRCTN03982913 | |
| MICE | Integrating Care for young people with epilepsy. | ||
| MINIMISE | Integrating Care for young people with epilepsy.. | ||
| MOTILITY | MRI for early response prediction to anti-TNF therapy. | ISRCTN14481560 | |
| MS-STAT2 | MS-STAT2 : Multiple Sclerosis - Simvastatin Trial 2. | ISRCTN82598726 | |
| NAMinG | Nicotinamide in Glaucoma (NAMinG) | N/a | |
| OPTIMAS | OPtimal TIMing of Anticoagulation after Stroke | ||
| RAFT | First in Human Phase I/II Clinical Trial of RAFT for Aniridia Related Keratopathy. | ISRCTN11428712 | |
| RESPONSE | Phase 1 safety study of Recombinant Surfactant Protein D to prevent neonatal Chronic Lung Disease (nCLD) in preterm infants. | ||
| RISAPS | A prospective randomised controlled phase II clinical trial of rivaroxaban versus warfarin in stroke patients with antiphospholipid syndrome, with or without SLE. | ISRCTN10280992 |
Completed Trials
| Trial Name | Title | Research Area | Trial Registry ID |
|---|---|---|---|
| ATTIRE | Albumin To prevenT Infection in chronic liveR failurE. | ISRCTN14174793 | |
| BEAT Lupus | Safety and Efficacy of Belimumab after B cell Depletion Therapy in Systemic Lupus Erythematosus. | ISRCTN47873003 | |
| COMPARE | Combination therapy for Pulmonary hypertension using RacEcadotril. | ISRCTN96717546 | |
| CROWN CORONATION | International, Bayesian platform adaptive, randomized, placebo-controlled trial assessing the effectiveness of candidate interventions in preventing COVID-19 disease in adults. | ISRCTN 99916292 | |
| DARC II | Retinal biomarkers of Alzheimer's disease in Down's syndrome. | ||
| EVERREST | Developing a therapy for Fetal Growth Restriction. | ||
| FACT | A Randomised, Single Masked, Non-Inferiority Trial of Femtosecond Laser Assisted vs Manual Phacoemulsification Cataract Surgery for Adults with Visually Significant Cataract. | ISRCTN77602616 | |
| FLARE | Favipiravir +/- Lopinavir: A RCT of Early antivirals. | ||
| HIPVAC | Human papillomavirus infection. | ISRCTN32729817 | |
| KERALINK | A Phase II Clinical Trial to establish Efficacy and Safety of cross-linking in children with Keratoconus. | ISRCTN17303768 | |
MIA | Minimally invasive autopsy for fetuses and children based on a combination of post-mortem MRI and endoscopic examination: a feasibility study. | ISRCTN68222801 | |
| RAPS | A prospective randomised controlled phase II/III non-inferiority clinical trial of rivaroxaban versus warfarin in patients with thrombotic antiphospholipid syndrome, with or without SLE. | ISRCTN68222801 | |
| SPREE | Screening programme for pre-eclampsia. | ISRCTN836115276 | |
| TARVA | Total Ankle Replacement vs Arthrodesis. | ISRCTN60672307 |