The Comprehensive Clinical Trials Unit at UCL


All CCTU Trials

A list of current and completed trials in CCTU can be seen below.

Current Trials

Trial NameTitleResearch AreaTrial Registry ID
ADEPT-PDAntidepressants in Parkinson's Disease. ISRCTN48548553

Primary Antibiotic prophylaxis using co-trimoxazole to prevent SpontanEous bacterial PeritoniTIs in Cirrhosis.



Ambroxol to Slow Progression in Parkinson Disease: A phase III multi-centre randomised placebo-controlled trial.

COG-UK HOCIA phase III prospective, interventional, cohort, superiority study to evaluate the benefit of rapid COVID-19 genomic sequencing (the COVID-19 GENOMICS UK project) on infection control in preventing the spread of the virus in United Kingdom NHS settings. ISRCTN50212645

Developmental Optimisation using Lavage in Preterm Haemorrhage in Infants in the UK: A national randomised controlled trial on the efficacy of neuro-endoscopic lavage.

 Registration in progress

A randomised, double blind, parallel group, placebo controlled Phase 3 trial of Exenatide once weekly over 2 years as a potential disease modifying treatment for Parkinson's disease.

HORACEPhase I/II open label, multicentre clinical trial to assess the safety and efficacy of ssAAV-LK03.hAAT.hcoOTC (Gene Therapy) for paediatric patients with ornithine transcarbamylase deficiency. Registration in progress
METRICMagnetic resonance Enterography (MRE) or ulTRasound In Crohn’s disease Extended Follow-up for predicting disabling disease. ISRCTN03982913
MICEIntegrating Care for young people with epilepsy.  
MINIMISEIntegrating Care for young people with epilepsy..  
MOTILITYMRI for early response prediction to anti-TNF therapy. ISRCTN14481560
MS-STAT2MS-STAT2 : Multiple Sclerosis - Simvastatin Trial 2. ISRCTN82598726
NAMinGNicotinamide in Glaucoma (NAMinG) N/a
OPTIMASOPtimal TIMing of Anticoagulation after Stroke  
RAFTFirst in Human Phase I/II Clinical Trial of RAFT for Aniridia Related Keratopathy. ISRCTN11428712
RESPONSEPhase 1 safety study of Recombinant Surfactant Protein D to prevent neonatal Chronic Lung Disease (nCLD) in preterm infants.  
RISAPSA prospective randomised controlled phase II clinical trial of rivaroxaban versus warfarin in stroke patients with antiphospholipid syndrome, with or without SLE. ISRCTN10280992

Completed Trials

Trial NameTitleResearch AreaTrial Registry ID

Albumin To prevenT Infection in chronic liveR failurE.

BEAT Lupus

Safety and Efficacy of Belimumab after B cell Depletion Therapy in Systemic Lupus Erythematosus.


Combination therapy for Pulmonary hypertension using RacEcadotril.

CROWN CORONATIONInternational, Bayesian platform adaptive, randomized, placebo-controlled trial assessing the effectiveness of candidate interventions in preventing COVID-19 disease in adults. ISRCTN 99916292
DARC IIRetinal biomarkers of Alzheimer's disease in Down's syndrome.  
EVERRESTDeveloping a therapy for Fetal Growth Restriction.  
FACTA Randomised, Single Masked, Non-Inferiority Trial of Femtosecond Laser Assisted vs Manual Phacoemulsification Cataract Surgery for Adults with Visually Significant Cataract. ISRCTN77602616
FLAREFavipiravir +/- Lopinavir: A RCT of Early antivirals.  
HIPVACHuman papillomavirus infection. ISRCTN32729817
KERALINKA Phase II Clinical Trial to establish Efficacy and Safety of cross-linking in children with Keratoconus. ISRCTN17303768


Minimally invasive autopsy for fetuses and children based on a combination of post-mortem MRI and endoscopic examination: a feasibility study. ISRCTN68222801
RAPSA prospective randomised controlled phase II/III non-inferiority clinical trial of rivaroxaban versus warfarin in patients with thrombotic antiphospholipid syndrome, with or without SLE. ISRCTN68222801
SPREEScreening programme for pre-eclampsia. ISRCTN836115276
TARVATotal Ankle Replacement vs Arthrodesis. ISRCTN60672307