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CHIMERA seminar with Professor Bindi Brook
08 March 2023, 3:00 pm–4:00 pm
Multiscale models of airway contraction and remodelling in asthma.
Event Information
Open to
- All
Availability
- Yes
Organiser
-
CHIMERA
Location
-
Zoom webinarOnlineOnlineOnline
Abstract
I will start by introducing an exciting new (well, it’s a year old) EPSRC-funded NetworkPlus entitled “Integrating data-driven biophysical models into respiratory medicine”. The aim of this network is to catalyze new partnerships linking researchers in academia, medicine, industry, and charity who are interested in the applications of mathematical modelling to lung health and respiratory medicine. I will then give some examples of related joint experimental-theoretical work my group has been doing to explore the role of tissue mechanics in bronchoconstriction and airway remodelling in asthma.
About the Speaker
Professor Bindi Brook
Professor of Mathematical Medicine and Biology at University of Nottingham
My current work is focussed on mathematical multi-scale models of airway hyper-responsiveness, inflammation and remodelling in asthma. The motivation for my research is to quantify the roles and interactions of the smooth muscle cells, tissues and chemical mediators that are involved in asthma. To this end my group is developing multi-scale mathematical models of airway contraction and remodelling, informed by experimental data that explicitly couples the force generated in airway smooth muscle cells arising from molecular level events, to biomechanical continuum models of airway tissue. The theoretical models that are being developed each require different mathematical approaches, from discrete-stochastic models at the sub-cellular level through to deterministic-continuum nonlinear (morpho)elastic models at the tissue level.