UCL Institute of Cardiovascular Science


Issue 20 - January 2013


Editor - Ruth Lovering

Gene annotation

This project has completed it's fifth year and we are pleased to confirm that based on the EBI statistics, 24th November 2012, this project has associated 27,500 GO terms to 3,800 proteins, 19,000 of which are to 2,200 human proteins. Many of these annotations have been generated through teaching MSc students, and we are very grateful to these students for their contribution to this annotation project.

The BHF-UCL annotations represent over 10% of all manual GO annotations associated with human proteins and we have been able to demonstrate an improved interpretation of high-throughput datasets using these annotations (Alam-Faruque et al. 2011).

Gene Ontology

During the past five years we have been active participants in several ontology development projects, including those expanding the description of heart development and cardiac conduction processes. In addition, we have ensured the creation of over 1000 GO terms to enable detailed annotation of cardiovascular-relevant proteins. This brings the total number of GO terms created by the BHF-UCL team to almost 1700. 


Scientific engagement

The ongoing efforts of the BHF-UCL team to promote GO to the scientific community are listed on our website, we have published six papers describing GO and cardiovascular annotation, since 2007, as well as a book chapter and an article for the British Society for Immunology magazine. We have also presented posters and given talks at a variety of meetings.

Community annotation

Registration is now open for our sixth GO Annotation Workshop (18-19th April 2013). This 2 day course provides hands-on training in the use of GO, as well as other bioinformatics resources, such as UniProt, Ensembl, Biomart, IntAct and Cytoscape. As always this workshop is freely available to all biological or biomedical PhD and Post-Doc research scientists. Please register for the April workshop, or contact us if you are interested in attending a future workshop.

Analysis of high-throughput datasets is an area we are often asked by scientists to help with. Consequently, we have now updated our 'resources' webpage to include information and links relevant to functional analysis tools.


We are sad to announce Varsha's departure from the team in the New Year. Varsha has been working at UCL on a variety of curation projects for over 10 years and she will be missed. Varsha first worked at UCL with Professor Povey in the HUGO Gene Nomenclature Committee (HGNC), where she was involved in naming many of the human genes during the Human Genome Project era. From here she moved to the Cardiovascular Genetics group, where she has made significant contributions to the development of the Gene Ontology describing cardiovascular processes, as well as to the GOC annotation dataset. We wish her all the best for the future and hope she finds an enjoyable new career path.

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