Structural Immunology Group

The Structural Immunology Group maintains a Molecular Interactions Facility.  Three methods (AUC, SAXS, SANS) involve the study of interactions in solution while two other methods (SPR, DPI) involve interactions at surfaces.  We perform molecular dynamics or Monte Carlo simulations in order to interpret the outcome of the AUC, SAXS and SANS experiments in terms of best-fit molecular models. We perform mass spectrometry studies at the Facility in UCL Chemistry.

The Facility is overseen by Professor Perkins and managed by Jayesh Gor.  It is down to each individual user to dedicate sufficient time to the project and arrange sufficient training from GE or Beckman-Coulter. We are interested in collaborations if this is what you wish to do. 

For all our users (including research students), we usually provide written training protocols and guidance for experimental plans and there is usually someone in the group who is willing to assist with measurements or subsequent data processing.

To access the facility, contact either Professor Perkins or Jayesh Gor

We have pioneered interactive websites that summarise information on genetic variants in the complement proteins (factor H, C3, factor I and membrane cofactor protein, as well as others) and the coagulation proteins of haemophilia (factor VII, factor VIII, factor IX, factor X, and factor XI).

Click on the links below to be taken to the websites

• Defects in Complement 
• Defects in Coagulation (FVII)
• Haemophilia A (FVIII)
• Haemophilia B (FIX)
• Defects in Coagulation (FX)
• Defects in Coagulation (FXI)