UCL Division of Biosciences


NPP & CDB Special Seminar - GL Brown Physiological Society Award, Prof Sandip Patel, UCL

28 April 2023, 3:00 pm–4:00 pm

Sandip Patel

Title: Ca2+ signaling through acidic organelles. From Ringer to the cell’s inner.

This event is free.

Event Information

Open to

All | UCL staff | UCL students | UCL alumni






Charlette Bent-Gayle – Neuroscience, Physiology and Pharmacology, UCL


131 A V Hill
Medical Sciences and Anatomy
Gower Street

Academic Host: David Attwell

Abstract: Changes in intracellular Ca2+ underpin our physiology. These changes are usually ascribed to entry of Ca2+ from the outside of the cell or release from the endoplasmic reticulum. But it is now clear that the so called ‘acidic Ca2+ stores’ are also part of the Ca2+ network. In this lecture, I discuss how lysosomes, once viewed solely as the cell’s recycling centre, are in fact dynamic Ca2+ signalling organelles in intimate contact with endoplasmic reticulum Ca2+ stores. I focus on a family of endo-lysosomal ion channels  - the two-pore channels – that are activated by the second messenger NAADP, and describe some of their recently discovered properties which challenge the text book view of how ion channels work.

Seminar Location: Medical Sciences, 131 A V Hill LT, Medical Sciences and Anatomy
Drink Reception Location: LG40/41 Gertrude Falk Room - Biosciences PGR Student Hub rooms at 16:00 onwards

This seminar offering will be Hybrid style. This seminar offering will be Hybrid style. Join us in person (preferably) or online.


About the Speaker

Prof Sandip Patel

Professor of Cell Signalling, CDB at University College London

Sandip Patel FRSB MAE is Professor at UCL.

He trained as a Medical Biochemist (Birmingham) and obtained his PhD in Pharmacology (Cambridge) with Colin Taylor followed by postdoctoral work with Andrew Thomas (Philadelphia/Newark) and Antony Galione (Oxford) as a Wellcome Trust International Travel Prize fellow. He started his own lab in Oxford which he moved to London in 2001, where is currently the Deputy Head of the Department of Cell and Developmental Biology.

Sandip’s work has helped develop the concept that acidic organelles such as lysosomes serve as patho-physiologically relevant stores of Ca2+.

He is and a member of several Editorial boards (including Cell Calcium) and Funding agency panels (including the Medical Research Council).

More about Prof Sandip Patel