New publication in Physical Review Letters for Saric and Baum Labs
23 November 2020
Exploring the Design Rules for Efficient Membrane-Reshaping Nanostructures.
Evolutionary algorithms take their inspiration from how natural evolution improves the design of living organisms for a certain function. They have been applied to a wide array of engineering problems, from the design of aircraft to the design of artificial muscles. In our study we couple an evolutionary algorithm to computer simulations to design nanoscale objects that reliably cross a cell membrane in a form of a vesicle. We simulate the performance of the objects, and then allow the best performing ones to mutate and exchange "genes" to be able to improve their cell-crossing performance. By following this evolution in sillico we were able to identify new and superior design rules that can explain several membrane-reshaping nanostructures found in nature and help design artificial membrane-crossing vehicles as well as inhibitors of viral entry.
- Research paper in Physical Review Letters
- Dr Andela Saric's academic profile
- Professor Buzz Baum's academic profile
- UCL Physics & Astronomy
- UCL MRC Laboratory for Molecular Cell Biology
- UCL Institute for the Physics of Living Systems