XClose

LMCB - MRC Laboratory for Molecular Cell Biology

Home
Menu
Buzz Baum's picture
LMCB Group Leader, UCL Professor of Cell Biology, IPLS Chair
 
+44 (0)20 7679 3040
LMCB Room 1.02
 
 
Cell Morphogenesis

Research Synopsis

The wider aims of our research are to better understand the evolution of eukaryotic cell shape and division, to determine how cells regulate their form, and to determine how these processes contribute to normal tissue development and homeostasis and, when they go awry, to the evolution of metastatic cancer. 

Baum Lab research image

Baum Lab research image

Selected Publications

Dix CL, et al (2018). The Role of Mitotic Cell-Substrate Adhesion Re-modeling in Animal Cell Division. Developmental Cell, 45(1):132-145.
Curran S, et al (2017). Myosin II Controls Junction Fluctuations to Guide Epithelial Tissue Ordering. Developmental Cell. 20:480-492.e6
Dey G, et al (2016). On the Archaeal Origins of Eukaryotes and the Challenges of Inferring Phenotype from Genotype. Trends in Cell Biology, 26 (7), 476-485. doi:10.1016/j.tcb.2016.03.009
Rodrigues NTL, et al (2015). Kinetochore-localized PP1-Sds22 couples chromosome segregation to polar relaxation. Nature, 524 (7566), 489-+. doi:10.1038/nature14496
Baum D & Baum B (2014). An inside-out origin for the eukaryotic cell. BMC Biol, 12, 76. doi:10.1186/s12915-014-0076-2

About the lab

Funders

Medical Research Council
Wellcome Trust
Cancer Research UK
European Research Council
BBSRC
VW
Human Frontier Science Program

Research Themes

Cytoskeleton and cell cortex, Polarity and cell shape, Cell-cell interactions, Physics of biological systems, Cell division and cell cycle, Evolution of the cell

Technology

Molecular genetics, Cell biology, Live cell imaging, Microfabrication, Biophysical approaches, Computational modeling, Super-resolution microscopy, Electron microscopy

People

Jigna Patel (Lab Manager, Research Assistant)
Helen Matthews (Postdoctoral Fellow)
Gautam Dey (Postdoctoral Fellow)
Diorge De Souza (Research Associate)
Andre Pulschen (Research Associate, HFSP Fellow)
Chantal Roubinet (Research Associate)
Zaw Win (Research Associate, Marie Curie Fellow)
Mateusz Trylinski (Research Fellow)
Sushila Ganguli (CRUK-UCL Centre Clinical PhD Fellow)
Gabriel Tarrason Risa (PhD Student, MRC)
Giulia Cazzagon (PhD Student, MRC)
 

Collaborators

Ewa Paluch (LMCB, UK)
Yanlan Mao (LMCB, UK)
Ricardo Henriques (LMCB, UK)
Rob de Bruin (LMCB, UK)
Andela Saric (UCL, UK)
Guillaume Charras (UCL, UK)
Guillaume Salbreux (CRICK, UK)
Finn Werner (UCL, UK)
Jochen Guck (BIOTEC, Germany)
Matthieu Piel (Institut Curie, France)
Tim Meyer (UCL, UK)
Wellcome consortium "Archaeal Origins of Eukaryotic Cell Organisation"
CRICK Biological Making Lab: Ravi Desai (CRICK, UK)