New BHF funded PSICQUIC dataset

We are pleased to announce that Tony Sawford, at the EBI, has created a new PSICQUIC dataset which can be used in Cytoscape analysis. The EBI-GOA-nonIntAct dataset includes all of the protein interaction data that has been created by the Gene Ontology (GO) Consortium.

Cardiovascular Project Newsletter

The UCL cardiovascular gene annotation newsletter is now available. Nancy has been submitting annotating protein complexes and Rachael has finished writing the GOC microRNA annotation guidelines.

Neurological Gene Annotation

green cells are brain astrocytes

The Parkinson’s UK Gene Ontology Initiative is funded by Parkinson's UK

The project represents a collaboration between 

By using Gene Ontology (GO) to curate scientific literature and by integrating results from high-throughput experiments we are creating an information-rich resource for the Parkinson’s disease community, enabling researchers to rapidly evaluate and interpret existing data and generate hypotheses to guide future research. Every GO annotation made is attributed to an identified source, such as a unique publication identifier (PubMed ID or PMID), and an indication of the type of evidence that supports the association between the gene product and the GO term. For an example, see the record of the LRRK2 protein – this is one focus of our ongoing annotation efforts. Annotations contributed by this project to the GO consortium dataset are attributed to ParkinsonsUK-UCL.

We are selecting and prioritizing genes and proteins related to Parkinson’s disease, based on multiple lines of evidence, for annotation.

A high-priority set of Parkinson's Disease-relevant genes have been selected based on genetic linkage or association studies:

A larger set of proteins were chosen based on their interaction with high-priority proteins or because of their role in Parkinson's-related biological processes and includes the gene products from the list above: 

We welcome feedback from scientists, in particular those studying Parkinson’s and Parkinson's-like diseases. We encourage researchers to review the annotation of their 'favourite' gene and suggest information that may be missing, inaccurate or incomplete in these annotations. 

Use the 'contact us' button to make comments or suggestions of papers or genes to be annotated.

Image kindly provided by Dr. Claudia Manzoni, UCL.

Page last modified on 24 aug 15 13:58

The work of the Cardiovascular Gene Annotation group is supported by British Heart Foundation grant RG/13/5/30112. The work of the Neurological Gene Annotation group is supported by Parkinson's UK grant G-1307. The Functional Gene Annotation team is supported by the National Institute for Health Research University College London Hospitals Biomedical Research Centre.