Neurological Gene Annotation
Annotations and GO terms contributed by this project to the GO Consortium database are attributed to ParkinsonsUK-UCL, ARUK-UCL or SynGO-UCL.
To find out more about Alzheimer's or Parkinson's diseases, please see the Alzheimer's Research UK or Parkinson's UK websites. The SynGO website provides more information about the Synapse Biology Annotation Initiative.
By using GO to curate the scientific literature we are creating a resource for the Parkinson’s, Alzheimer's and neurological research communities that will enable researchers to rapidly evaluate and interpret existing data and generate hypotheses to guide future research.
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We are using the GOA-UniProt curation tool to associate Gene Ontology (GO) terms with neurological-relevant proteins; this data is then incorporated into the GOA-UniProt and GO Consortium databases. All of our annotations are then propagated to freely available online knowledgebases, such as UniProt, Ensembl and NCBIGene, as well as other public and commercial analysis tools.
One of the approaches we take is to annotate one biological process at a time, rather than one gene product at a time. This approach has several advantages, including: broadening our annotations to include more of the proteins associated with the process, improving the biocurator's knowledge of the biology and creating more specific annotations. In turn, this leads to requests for more specific GO terms, because we are investing in improving the annotation of the domain.
What we curate
- Alzheimer's Research UK-funded initiative to annotate proteins involved in neuroinflammation, starting with dementia-relevant microglial processes
- SynGO project: an international collaborative effort to annotate synaptic proteins
- Alzheimer's Research UK-funded GO annotation initiatives to annotate amyloid-beta receptors and tau-binding proteins
- Parkinson's UK-funded GO annotation initiative to annotate processes relevant to Parkinson's disease. Example of a curated protein: human LRRK2.
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