New BHF funded PSICQUIC dataset

We are pleased to announce that Tony Sawford, at the EBI, has created a new PSICQUIC dataset which can be used in Cytoscape analysis. The EBI-GOA-nonIntAct dataset includes all of the protein interaction data that has been created by the Gene Ontology (GO) Consortium.

microRNA annotation

Our first release of GO annotations describing the biological roles of cardiovascular-relevant microRNAs is now available. See Gene Ontology microRNAs for more information.

Cardiovascular Gene Annotation

QuickGO view of part of heart valve ontology

The Cardiovascular Gene Annotation Initiative is funded by the British Heart Foundation.

The project represents a collaboration between:

This collaboration builds on our previous 5 year annotation initiative which led to the associated over 16,000 GO terms to 1919 human proteins, for an example, see the annotation record of the fully annotated APOA4 protein. In addition. during these 5 years we contributed to the creation of over 1100 GO terms; over 500 of these terms were developed following ontology discussions with experts in heart development and cardiac conduction.

These new BHF-funded GO terms facilitated the detailed and high-quality annotation of cardiovascular-relevant genes. The impact of which is demonstrated in Alam-Faruque, 2011.

In the current project we will be dividing our time equally between the GO annotation of microRNAs, proteins and the capture of protein-protein interactions. Annotations contributed by this project to the GO consortium dataset and the IMeX dataset are attributed to BHF-UCL.

We have prioritised 4,000 cardiovascular-associated proteins for annotation: 

The prioritisation of microRNAs is ongoing.

We welcome feedback from cardiovascular scientists and encourage researchers to review the annotation of their 'favourite' gene and suggest information that may be missing, inaccurate or incomplete in these annotations. 

Use the 'contact us' button to make comments or suggestions of papers or genes to be annotated.

Page last modified on 01 aug 15 09:34

The work of the Cardiovascular Gene Annotation group is supported by British Heart Foundation grant RG/13/5/30112. The work of the Neurological Gene Annotation group is supported by Parkinson's UK grant G-1307. The Functional Gene Annotation team is supported by the National Institute for Health Research University College London Hospitals Biomedical Research Centre.