Cardiovascular Gene Ontology

The Cardiovascular Gene Ontology Annotation Initiative represents a collaboration between University College London and the European Bioinformatics Institute (EBI), funded by the British Heart Foundation.  This annotation group is a member of the GO Consortium.

The Gene Ontology (GO) vocabulary is the established standard for the functional annotation of gene products. By using GO to curate scientific literature and by integrating results from high-quality high-throughput experiments we will create an information-rich resource for the cardiovascular-research community, enabling researchers to rapidly evaluate and interpret existing data and generate hypotheses to guide future research.  Over 4,000 cardiovascular associated genes have been identified.  (Further information: how the list was generated ; browse the gene list)

Every GO annotation made is attributed to an identified source, such as a publication identifier (PMID), and indicates what kind of evidence supports the association between the gene product and the GO term (see QuickGO view of fully annotated APOA4 record). Annotations contributed by this Initiative to the GO consortium dataset are listed as BHF-UCL; British Heart Foundation - University College London.

We have provided a variety of tools to enable cardiovascular scientists to review the annotation of their 'favourite' gene and suggest information that may be missing, inaccurate or incomplete in these annotations.  Annotation suggestions can be sent through our feedback form or by email.

Tuesday 15 May: EBI enzyme and metabolite resources training workshop

Find out more about this workshop or book online.

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The work of the Cardiovascular Gene Ontology Annotation group is supported by British Heart Foundation grant SP/07/007/23671