MEDC0079 Module 5: Biological screening methods, X-ray, protein NMR and phenotypic screening

Module Structure: (15 credits each) • Lectures and Tutorials • Assessment: 50% coursework, 50% unseen examination.

Module Title	Module 5: Biological screening methods, X-ray, protein NMR and phenotypic screening
Module Code	MEDC0079
Module Leader	Dr Edith Chan
Short description	Biophysical and Phenotypic methods are routinely used in Drug Discovery projects. These modern techniques could be applied to compound screening, structural determination and kinetics of the protein-ligand complexes as well as in target identification in cell-based screening.
Module aims	To understand the principle and concept of all major biological screening methods, their pros and cons. The use of phenotypic screening To learn High-throughput screening and its practices in Pharma and Biotech
List of Lectures and Tutorials	Biophysical screening methods for fragments/ X-ray data on fragments Protein NMR and Biocore Phenotypic screening High-throughput screening Journal club
Module assessment	50% course work + 50% unseen 1 hour exam