Short courses


Downstream Processing: Primary Recovery (MBI Training, Bioprocess Industries)

  • 24 hours (approx)
  • 4 days


This four-day online course focuses on the product recovery stage of rapid bioprocessing of biological products.

You'll learn about integrated solutions for rapid bioprocessing of biologics and how to select the most suitable recovery operation for your bioprocess.

The course involves lectures, case studies and practical sessions.

It's aimed at scientists and engineers.

This course is part of the Modular Training for the Bioprocess Industries programme (MBI), run by the Department of Biochemical Engineering at UCL.

Course content and structure

Teaching will be online. You'll be taught in small classes, with an emphasis on interactive problem solving and case studies.

Each day will cover the following topics:

Day 1

  • Centrifugation principles and design
  • Ultra scale-down of solid-liquid separation operations
  • Filtration principles and process performance
  • Microfiltration/ultrafiltration operational characteristics

    Day 2

    • Pilot-plant and ultra scale-down studies: centrifugation
    • Intracellular product release
    • Bioprocess application of centrifuges
    • Ultra scale-down filtration and cell recovery and membrane separation operations

    Day 3

    • Pilot-plant studies: microfiltration
    • From lab scale to manufacturing: micro-filtration technologies for product recovery and purification
    • Ultra scale-down of conditioning and recovery operations: precipitation, crystallisation and flocculation
    • Use of adsorptive depth filtration in biopharmaceutical manufacturing

      Day 4

      • Simulation studies: the role of microfiltration in whole bioprocess studies
      • Cell engineering to ease primary recovery
      • Primary recovery process development with an integrated approach

      Who the course is for

      This course is for scientists and engineers involved in design, development and operation of primary recovery steps and associated steps in upstream and purification processes.

      Typically those who attend are:

      • bioprocess developers
      • R&D scientists
      • manufacturing technologists
      • manufacturing operational managers

      Learning outcomes

      After completing this course you should be able to:

      • understand the principles of all the major recovery operations: centrifugation, membrane systems, filtration, cell disruption, precipitation, flocculation
      • compare these unit operations for suitability within the process
      • determine the most appropriate equipment for separations and specify the right operating conditions
      • use the ultra scale-down tool for predicting large-scale separation performance
      • understand the interaction among fermentation, recovery and purification and integrated solutions for bioprocess development

      Costs and group bookings

      The standard price for this course is £1,750.

      Special prices are available for groups and SMEs. Contact mbi-training@ucl.ac.uk for more information.

      Modular Training for the Bioprocess Industries (MBI)

      The award-winning MBI programme is a series of UCL-accredited short courses for people working in the bioprocessing industry. It's designed and delivered in collaboration with over 70 industrial experts.

      The programme provides flexible professional development training. You can choose to take standalone courses or combine them for a Certificate, Diploma or Master's qualification. It complements in-house training by providing broader perspectives for more informed decision-making.

      Courses have so far been delivered to over 900 individuals from more than 300 companies, 30% of which are non-UK, demonstrating its strong international impact.

      MBI plays a central role in the department's knowledge-transfer activities. This ensures that cutting-edge research is undertaken to capture the value of integrating engineering with complex and fast-moving biology, which helps keep the global industry ahead in manufacturing.

      Benefits of MBI

      By attending an MBI course, you'll:

      • benefit from knowledge transfer and upskilling in core bioprocessing fundamentals and trends in industry
      • gain a deeper understanding of process options and engineering constraints
      • acquire the tools to optimise process performance and economics
      • learn about the latest technical and regulatory developments
      • have access to cutting edge research methodologies
      • network with sector leaders and subject matter experts
      • increase your flexibility, motivation, creativity and professional status

      Further information

      There is more information about the MBI on the Department of Biochemical Engineering's website. If you have questions about fees or how to combine courses for a specific qualification, please email mbi-training@ucl.ac.uk

      Course team

      Andrea Rayat

      Andrea Rayat

      Andrea is Associate Professor in the Department of Biochemical Engineering at UCL.

      Course information last modified: 30 Nov 2022, 16:01