Centre for Respiratory Biology


Centre for Respiratory Biology

The group focuses on understanding disease mechanisms and the search for novel therapies.

A common theme is combating pathological polymers including those that lead to serpinopathies, such as antitrypsin deficiency.

We also seek to combat the pathological polymers that lead to neurodegenerative diseases, including Alzheimer's disease.

To this end and with the aim of expediting translation to the clinic, structural, molecular and cell-based studies are pursued, alongside work on animal models (C. elegans), together with target-based and phenotypic drug screening. 

Head of Centre

Principal Investigators


EM image of polymers appear as 'beads on a string'

Our diverse research focuses on: (i) the study of the serpin α1-antitrypsin and the propensity of its mutants to polymerise into inactive inclusions, (ii) the study of other pathological polymer diseases and (iii) the discovery of novel and improved compounds to treat tropical diseases and insect pests.



The Centre for Respiratory Biology provides high-quality research projects within a world-class facility to undergraduate and postgraduate science students led by an exciting and supportive team of researchers.





Here you can find a list of all our research papers.  


Research Techniques

NMR Structural Changes

Our research expertise encompasses a diverse range of techniques that spans molecular and cellular biology, bioinformatics, biochemistry, biophysics, structural biology, HTP drug screening, invertebrate biology and electrophysiology.