Prof Mire Zloh
Associate Lecturer (Teaching)
UCL School of Pharmacy
Faculty of Life Sciences
- Joined UCL
- 1st Jan 2012
Design and Structural Investigation of Dendrimers
Dendrimers, well-defined branched symmetrical macromolecules, used for targeted drug delivery by encapsulation or conjugation of drugs on the surface. Molecular dynamics simulations are used to understand their structure, physicochemical properties and intermolecular interactions. We are using this information to computationally design macromolecular dendrimer based with optimal properties useful for treating diseases (Barata et al, Biomaterials, doi:10.1016/j.biomaterials.2011.07.085),
The molecular modeling of hyperbranched molecules is currently constrained by difficulties in model building, due partly to lack of parameterization of their building blocks and branched topology. We have addressed this problem by developing a method that translates monomeric linear sequences into a full atomistic model of a hyperbranched molecule (Barata et al, J. Mol. Mod. DOI: 10.1007/s00894-011-0966-y). Such molecular-modeling-based advances are enabling theoretical studies of important biological interactions between naturally occurring macromolecules and synthetic macromolecules (Barata et al, PLOS Comp. Biol. doi:10.1371/journal.pcbi.1002095). Our results also suggest that it should be possible to apply this sequence-based methodology to generate hyperbranched structures of other dendrimeric structures and of linear polymers.
In silico Screening for Modulators of Efflux Pumps
The ineffectiveness of antibiotics and anticancer drugs can be caused by multidrug resistance (MDR). The activity of drugs can be restored by co-administration of efflux pump modulators. We have proposed that modulators of MDR might form complexes with substrates of efflux pumps to act as “escort” molecules and deliver drugs to the site of action (Zloh et al., Bioog. Med. Chem Lett. doi:10.1016/j.bmcl.2003.12.015). We have evaluated interaction energies between a series of drugs and MDR modulators and confirm a qualitative correlation with potentiating ability of “escort” molecules. Additionally, the change of log P of complexes might be responsible for overcoming the membrane impermeability and the activity of drugs in the presence of the modulators. This suggests that interactions between small molecules may play an important role in overcoming biological barriers in bacteria.
Mire Zloh was a Visiting Professor at the UCL School of Pharmacy until January 2021, when he took position of a Teaching Fellow.
He holds the Emeritus Professor of Medicinal Chemistry with University of Hertfordtshire, where he was the Head of Pharmaceutical Chemistry and Research Professor from January 2013 until September 2017. He also acts as Innovation Advisor to Dean of the Faculty of Pharmacy, University Business Academy in Novi Sad Serbia and is a director of Nanopuzzle Medicines Design Ltd.
Prior to his present position was Senior Lecturer at the UCL School of Pharmacy and was responsible for the integrated structural chemistry service that provides NMR, MS and CHN analysis to internal and external users. He was an Assistant Professor at the Faculty of Pharmacy in Belgrade for the Clinical Chemistry Instrumentation course before moving to London. From 2002 to 2003, he was a tutor counselor for the Open University. Prof. Zloh was Deputy Director on the MSc Course in Drug Discovery at UCL School of Pharmacy.
Prof. Zloh has continued collaborating with colleagues at the UCL School of Pharmacy. He has external collaborations with professors Tatjana Verbic, Slavica Eric and Vladirmir Savic (University of Belgrade), Dr Petros Tsoungas (Greece), Professor Helena Florindo (University of Lisbon) and Professor Liping Wang (Nanjing Agricultural University, China).
Prof. Mire Zloh graduated in Physical Chemistry from the University of Belgrade (Yugoslavia) in 1987. He was then awarded an MSc in Physical Chemistry from the same university in 1992. His research in structural biology resulted in a PhD in Chemistry from the University of London in 1998 with a thesis entitled "Conformational Studies of the High Affinity IgE Receptor Peptides and Domains by NMR and Molecular Modelling".He was elected as a Fellow of the Royal Society of Chemistry and he is a member of Academy of Pharmaceutical Sciences and Serbian Chemical Society.