Karin Shmueli

Lecturer in Magnetic Resonance Imaging

and Undergraduate Admissions Tutor

Photograph of Karin Shmueli

Address

Department of Medical Physics and Bioengineering
Malet Place Engineering Building
University College London
Gower Street
LONDON
WC1E 6BT

Contact details

Room number:
Phone:
Internal:
Fax:
Email address
2.02
+44 (0)20 7679 0256
x30256
+44 (0)20 7679 0255
k.shmueli@ucl.ac.uk

Research Interests

I am interested in developing Magnetic Resonance Imaging (MRI) techniques to increase image contrast and resolution by exploiting new contrast mechanisms. The current goal of my research programme is to characterise frequency and susceptibility contrasts and to develop and translate MRI techniques exploiting these mechanisms to improve disease diagnosis and monitoring of therapies.

Conventional MRI uses only the signal magnitude, but utilising the frequency (or phase) of the MRI signal has dramatically improved visualisation of tissue structure and can reveal tissue composition. During my previous post at the USA National Institutes of Health, I developed new methods to calculate tissue magnetic susceptibility maps from MRI frequency images. MRI tissue Susceptibility Mapping is an exciting technique and a rapidly growing research area. Together with my research group and collaborators, I now aim to unlock the potential of these MRI frequency and susceptibility methods to generate clinical MRI biomarkers of disease.

Teaching Activities

Education

Publications

    2012

    • Lee, J., Shmueli, K., Kang, B. T., Yao, B., Fukunaga, M., van Gelderen, P., Palumbo, S., Bosetti, F., Silva, A. C., Duyn, J. H. (2012). The contribution of myelin to magnetic susceptibility-weighted contrasts in high-field MRI of the brain. Neuroimage 59(4), 3967-3975 doi:10.1016/j.neuroimage.2011.10.076. Author URL
    • Yao, B., Li, T. -. Q., van Gelderen, P., Shmueli, K., de Zwart, J. A., Duyn, J. H. (2012). Corrigendum to "Susceptibility contrast in high field MRI of human brain as a function of tissue iron content" [NeuroImage 44/4 (2009) 1259-1266] (DOI:10.1016/j.neuroimage.2008.10.029). NeuroImage
    • Yao, B., Li, T. -. Q., van Gelderen, P., Shmueli, K., de Zwart, J. A., Duyn, J. H. (2012). Corrigendum to "Susceptibility contrast in high field MRI of human brain as a function of tissue iron content" [NeuroImage 44/4 (2009) 1259-1266]. NeuroImage 62(3), 2173-2173 doi:10.1016/j.neuroimage.2012.03.055.

    2011

    • O'Gorman, R. L., Shmueli, K., Ashkan, K., Samuel, M., Lythgoe, D. J., Shahidiani, A., Wastling, S. J., Footman, M., Selway, R. P., Jarosz, J. (2011). Optimal MRI methods for direct stereotactic targeting of the subthalamic nucleus and globus pallidus. Eur Radiol 21(1), 130-136 doi:10.1007/s00330-010-1885-5. Author URL
    • Shmueli, K., Dodd, S. J., Li, T. Q., Duyn, J. H. (2011). The contribution of chemical exchange to MRI frequency shifts in brain tissue. Magn Reson Med 65(1), 35-43 doi:10.1002/mrm.22604. Author URL

    2010

    • Fukunaga, M., Li, T. Q., van Gelderen, P., de Zwart, J. A., Shmueli, K., Yao, B., Lee, J., Maric, D., Aronova, M. A., Zhang, G., Leapman, R. D., Schenck, J. F., Merkle, H., Duyn, J. H. (2010). Layer-specific variation of iron content in cerebral cortex as a source of MRI contrast. Proc Natl Acad Sci U S A 107(8), 3834-3839 doi:10.1073/pnas.0911177107. Author URL
    • Lee, J., Shmueli, K., Fukunaga, M., van Gelderen, P., Merkle, H., Silva, A. C., Duyn, J. H. (2010). Sensitivity of MRI resonance frequency to the orientation of brain tissue microstructure (Proceedings National Academy Science USA (2010) 107, (5130-5135) DOI: 10.1073/pnas.0910222107). PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 107(18), 8498-8498 doi:10.1073/pnas.1003440107. Author URL
    • Lee, J., Shmueli, K., Fukunaga, M., van Gelderen, P., Merkle, H., Silva, A. C., Duyn, J. H. (2010). Sensitivity of MRI resonance frequency to the orientation of brain tissue microstructure. Proc Natl Acad Sci U S A 107(11), 5130-5135 doi:10.1073/pnas.0910222107. Author URL
    • Shahidiani, A., O'Gorman, R. L., Shmueli, K., Lythgoe, D. J., Wastling, S. J., Footman, M., Samuel, M., Selway, R. P., Jarosz, J., Ashkan, K. (2010). Optimal MRI methods for direct stereotactic targeting of the subthalamic nucleus and globus pallidus. MOVEMENT DISORDERS. ( Vol. 25 pp.S392-S393). Author URL

    2009

    • Bianciardi, M., Fukunaga, M., van Gelderen, P., Horovitz, S. G., de Zwart, J. A., Shmueli, K., Duyn, J. H. (2009). Sources of functional magnetic resonance imaging signal fluctuations in the human brain at rest: a 7 T study. Magn Reson Imaging 27(8), 1019-1029 doi:10.1016/j.mri.2009.02.004. Author URL
    • Shmueli, K., de Zwart, J. A., van Gelderen, P., Li, T. Q., Dodd, S. J., Duyn, J. H. (2009). Magnetic susceptibility mapping of brain tissue in vivo using MRI phase data. Magn Reson Med 62(6), 1510-1522 doi:10.1002/mrm.22135. Author URL
    • Shmueli, K., O'Gorman, R., Lythgoe, D., Samuel, M., Selway, R., Ashkan, K., Jarosz, J. (2009). MRI magnetic susceptibility mapping of target structures for deep brain stimulation (DBS). MOVEMENT DISORDERS. ( Vol. 24 pp.S205-S205). Author URL
    • Yao, B., Li, T. Q., Gelderen, P. V., Shmueli, K., de Zwart, J. A., Duyn, J. H. (2009). Susceptibility contrast in high field MRI of human brain as a function of tissue iron content. Neuroimage 44(4), 1259-1266 doi:10.1016/j.neuroimage.2008.10.029. Author URL

    2007

    • Shmueli, K., Thomas, D. L., Ordidge, R. J. (2007). Design, construction and evaluation of an anthropomorphic head phantom with realistic susceptibility artifacts. Journal of Magnetic Resonance Imaging 26, 202-207
    • Shmueli, K., van Gelderen, P., de Zwart, J. A., Horovitz, S. G., Fukunaga, M., Jansma, J. M., Duyn, J. H. (2007). Low-frequency fluctuations in the cardiac rate as a source of variance in the resting-state fMRI BOLD signal. Neuroimage 38(2), 306-320 doi:10.1016/j.neuroimage.2007.07.037. Author URL

    2003

    • De Vita, E., Thomas, D. L., Roberts, S., Parkes, H. G., Turner, R., Kinchesh, P., Shmueli, K., Yousry, T. A., Ordidge, R. J. (2003). High resolution MRI of the brain at 4.7 Tesla using fast spin echo imaging. British Journal of Radiology 76(909), 631-637 doi:10.1259/bjr/69317841.

    2001

    • McRobbie, D., Quest, R., Shmueli, K. (2001). BOLD contrast modifications due to fat suppression in long TR functional magnetic resonance imaging. NEUROIMAGE. ( Vol. 13 pp.S31-S31). Author URL
    • Nagaraj, N., Shmueli, K., Nadir, F. (2001). Plasma volume (PV) measurement in suspected polycythaemia - Direct measurement or indirect measurement? EUROPEAN JOURNAL OF NUCLEAR MEDICINE. ( Vol. 28 pp.1220-1220). Author URL