Medical Physics and Biomedical Engineering


Clinical studies

Neonatal brain injury

In October 2013 the instrument, called CYRIL, was installed in the UCLH NICU to assess the feasibility of continuous monitoring of infants with HIE (see Presentation-Gemma). Since then we have monitored more than 80 infants with HIE during the first week of life and have demonstrated (i) that relationship of brain oxygenation and oxCCO during spontaneous desaturation events can be indicative of the severity of the brain injury[9]; (ii) the association between the brain tissue oxCCO and systemic physiology fluctuations is highly correlated in infants with severe HIE[10, 11]; and (iii) the relationship between brain oxygenation and oxCCO during rewarming after therapeutic hypothermia was dependent on the severity of injury[12]. In addition, we have demonstrated that the continuous metabolic measurement of oxCCO provides unique information regarding brain health during neonatal stroke[13] and neonatal seizures[14].

5.  Bale, G., C.E. Elwell, and I. Tachtsidis, J Biomed Opt, 2016. 21(9): p. 091307.

6.  Sakata, Y., et al., Biomed Opt Express, 2012. 3(8): p. 1933-46.

7.  Matcher, S.J., M. Cope, and D.T. Delpy, Phys Med Biol, 1994. 39(1): p. 177-96.

8.  Bainbridge, A., et al., Neuroimage, 2014. 102 Pt 1: p. 173-83.

9.  Bale, G., et al., Biomed Opt Express, 2014. 5(10): p. 3450-66.

10. Bale, G., et al., Adv Exp Med Biol, 2016. 923: p. 181-6.