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Medical Physics and Biomedical Engineering

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Adam Gibson

Professor of Medical Physics
 

 Research
My group’s research is based around solving clinical problems by intelligent use of multimodal imaging data. This is divided between four themes:

  • Optical Imaging - My main research area has been developing optical tomography for breast cancer and functional brain imaging of adults and children. It is currently supported by 3 grants, and a long-term collaboration with Addenbrookes Hospital in Cambridge.
  • Radiotherapy - I am applying multimodality imaging techniques to radiotherapy, particularly as part of UCL’s new Proton Therapy Centre.
  • Intelligent analysis of routinely acquired patient data - Examples include neonatal monitoring, predicting cancer outcomes and examining risk factors for breast cancer.
     
  • Multispectral imaging of historical manuscripts - I am extending multimodality medical imaging techniques to recovering lost text in historical documents with the UCL Centre for Digital Humanities. See, for example, the Deep Imaging project.

Departmental responsibilities

2013               Programme Tutor for BEng/MEng Engineering (Biomedical)

2012               Chair of Departmental Research Committee

2012              Creator and editor of Departmental Newsletter and Open Day

2011               Lecturer on MPHY101P, MPHY2001, MPHY3892

2009               Creator and editor of Departmental Website and Museum

Publications

Refereed articles

  1. Campagnolo, A., Giacometti, A., MacDonald, L., Mahony, S., Terras, M., & Gibson, A. (2016). Cultural Heritage Destruction: Experiments with Parchment and Multispectral Imaging. In G. Bodard, M. Romanello (Eds.), Digital Classics Outside the Echo-Chamber: Teaching, Knowledge Exchange & Public Engagement.(pp. 121-146). London: Ubiquity Press. doi:10.5334/bat.h
  2. Brigadoi, S., Powell, S., Cooper, R. J., Dempsey, L. A., Arridge, S., Everdell, N., Gibson, A. P. (2015). Evaluating real-time image reconstruction in diffuse optical tomography using physiologically realistic test data. Biomedical Optics Express, 6 (12), 4719-4736. doi:10.1364/BOE.6.004719
  3. Doolan, P. J., Alshaikhi, J., Rosenberg, I., Ainsley, C. G., Gibson, A., D'Souza, D., Royle, G. (2015). A comparison of the dose distributions from three proton treatment planning systems in the planning of meningioma patients with single-field uniform dose pencil beam scanning. JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS, 16 (1), 86-99.
  4. Dempsey, L. A., Cooper, R. J., Roque, T., Correia, T., Magee, E., Powell, S., Gibson A, Hebden, J. C. (2015). Data-driven approach to optimum wavelength selection for diffuse optical imaging. J Biomed Opt, 20 (1), 016003-?. doi:10.1117/1.JBO.20.1.016003
  5. Doolan, P. J., Royle, G., Gibson, A., Lu, H-M., Prieels, D., & Bentefour, E. H. (2015). Dose ratio proton radiography using the proximal side of the Bragg peak. MEDICAL PHYSICS, 42 (4), 1871-1883. doi:10.1118/1.4915492
  6. Giacometti, A., Terras, M. M., & Gibson, A. (2015). Objectively Evaluating Text Recovery Methodologies for Multispectral Images of Palimpsests.International Journal of Heritage in the Digital Era, 15th Issue dedicated to Computer Vision in Cultural Heritage.
  7. Ricketts, K., Williams, M., Liu, Z-W., & Gibson, A. (2014). Automated estimation of disease recurrence in head and neck cancer using routine healthcare data. Computer Methods and Programs in Biomedicine. doi:10.1016/j.cmpb.2014.08.008
  8. Helo, Y., Kacperek, A., Rosenberg, I., Royle, G., & Gibson, A. P. (2014). The physics of Cerenkov light production during proton therapy. Phys. Med. Biol, 59 (2014), 7107-7123. doi:10.1088/0031-9155/59/23/7107
  9. Ricketts, K. P., Cheema, U., Nyga, A., Castoldi, A., Guazzoni, C., Magdeldin, T., Loizidou, M. (2014). A 3D In Vitro Cancer Model as a Platform for Nanoparticle Uptake and Imaging Investigations. Small. doi:10.1002/smll.201400194
  10. La Rosa V, Kacperek A, Royle G & Gibson AP (2014). Range verification for eye proton therapy based on proton-induced x-ray emissions from implanted metal markers. Phys Med Biol, (59)11 p2623
  11. Proverbio A, Siow BM, Lythgoe MF, Alexander DC & Gibson AP (2014),Multimodality characterization of microstructure by the combination of diffusion NMR and time-domain diffuse optical data. Phys Med Biol, (59)11 p2639
  12. Cooper RJ, Magee E, Everdell N, Magazov S, Varela M, Airantzis D, Gibson AP, Hebden JC (2014). MONSTIR II: A 32-channel, multispectral, time-resolved optical tomography system for neonatal brain imaging. Rev Sci Instrum, 85 (5), 053105. doi:10.1063/1.4875593
  13. Helo, Y., Rosenberg, I., D'Souza, D., Macdonald, L., Speller, R., Royle, G., & Gibson, A. (2014). Imaging Cerenkov emission as a quality assurance tool in electron radiotherapy. Phys Med Biol, 59 (8), 1963-1978. doi:10.1088/0031-9155/59/8/1963
  14. Eadie, L., Enfield, L., Taylor, P., Michell, M., & Gibson, A. (2013). Breast cancer risk scores in a standard screening population. Breast Cancer Management, 2 (6), 463-479.
  15. Ricketts K, Guazzoni C, Castoldi A, Gibson A Royle GJ (2013). An x-ray fluorescence imaging system for gold nanoparticle detection. Phys Med Biol, 58 (21), 7841-. doi:10.1088/0031-9155/58/21/7841
  16. Reid CB, Reese G, Gibson AP, Wallace VP (2013) "Terahertz Time-Domain Spectroscopy of Human Blood" IEEE J Biomed Health Inf. 17(4):774-778 Full paper
  17. Enfield LC, Hebden JC, Gibson AP. (2013) The reproducibility of optical mammography in healthy volunteers. Phys Med Biol 58(13):4579-4594
  18. MacDonald, L., Giacometti, A., Gibson, A., Campagnolo, A., Robson, S., Weyrich, T., & Terras, M. (2013). Multispectral imaging of degraded parchment.Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), 7786 LNCS, 143-157. doi:10.1007/978-3-642-36700-7_12
  19. Enfield L, Cantanhede G, Douek M, Ramalingam V, Purushotham A, Hebden J, Gibson A. (2013) Monitoring the response to neoadjuvant hormone therapy for locally advanced breast cancer using three-dimensional time-resolved optical mammograph.. J Biomed Opt 18(5):560
  20. Ricketts K, Castoldi A, Guazzoni C, Christodoulou C, Gibson A P, Royle G J (2012) "A quantitative x-ray detection system for gold nanoparticle tumour biomarkers"Phys Med Biol57 5543-5555 Full paper
  21. Correia T, Lloyd-Fox S, Everdell N, Blasi A, Elwell C, Hebden JC, Gibson AP (2012) "Three-dimensional optical topography of brain activity in infants watching videos of human movement." Phys Med Biol 57(5) p1135-1146 Full paper
  22. Enfield, LC and Gibson, AP (2012) "Review: A review of mechanisms of contrast for diffuse optical imaging of cancer". Journal of Near Infrared Spectroscopy, 20(1) 185 - 202.
  23. Enfield LC, Cantanhede G, Westbroek D, Douek M, Purushotham AD, Hebden JC, Gibson AP (2011) "Monitoring the response to primary medical therapy for breast cancer using three-dimensional time-resolved optical mammography". Technol Cancer Res Treat 10(6):533-547 Full paper
  24. Eadie, LH, Taylor P, Gibson AP (2012) "Recommendations for research design and reporting in computer-assisted diagnosis to facilitate meta-analysis" J. Biomed. Inf. 45(2) p390–397 Full paper
  25. Reid C, Fitzgerald F, Reese G, Goldin R, Tekkis P, O'Kelly P S, Pickwell-MacPherson E, Gibson AP, Wallace VP (2011) "Terahertz pulsed imaging of freshly excised human colonic tissues" Phys. Med. Biol. 56 4333 Full paper
  26. Eadie, LH, Taylor P, Gibson AP (2011) "A systematic review of computer-assisted diagnosis in diagnostic cancer imaging" Eur. J. Radiol. Full paper
  27. Elisee J, Gibson AP, Arridge SR (2011) "Diffuse optical cortical mapping using the boundary element method," Biomed. Opt. Express 2, 568-578  Full paper
  28. Cooper RJ, Hebden, JC, O'Reilly H, Mitra S, Mitchell A, Everdell NL, Gibson AP, Austin T (2011) "Transient haemodynamic events in neurologically compromised infants: A simultaneous EEG and diffuse optical imaging study" Neuroimage 55(4) 1610-1616 Full paper
  29. Cooper RJ, Eames R, Brunker J, Enfield LC, Gibson AP, Hebden JC (2010) "A tissue equivalent phantom for simultaneous near-infrared optical tomography and EEG" Biomed. Opt. Exp., 1(2), pp. 425-430 Full paper
  30. Correia T, A P Gibson, J C Hebden (2010) "Identification of the optimal wavelengths for optical topography: a photon measurement density function analysis" J. Biomed. Opt. 15, 056002 Full paper
  31. Elisee J, Gibson AP, Arridge SR (2010) "Combination of Boundary Element Method and Finite Element Method in Diffuse Optical Tomography" IEEE Trans Biomed EngFull paper
  32. Reid CB, Pickwell-MacPherson E, Laufer JG, Gibson AP, Hebden JC, Wallace VP (2010) "Accuracy and resolution of THz reflection spectroscopy for medical imaging" Phys. Med. Biol. 55 (16) 4825–4838 Full paper
  33. Price B, Gibson AP, Tan LT, Royle, GJ (2010) "An elastically compressible phantom material with mechanical and x-ray attenuation properties equivalent to breast tissue" Phys. Med. Biol. 55 1177-118 Full paper
  34. Enfield L, Gibson A P, Hebden J C and Douek, M (2009) "Optical Tomography of Breast Cancer - monitoring response to primary medical therapy" Targeted Oncology 4(3) 219-233 Full paper
  35. Gibson A P, Chandra E and Chandra M (2009) "Pulse oximetry as a medical physics practical on school trips" Phys. Educ. 44 577-581. Full paper
  36. Correia T, Gibson A P, Schweiger M, and Hebden JC (2009) "Selection of regularization parameter for optical topography". J. Biomed. Opt. 14, 034044 Full paper
  37. Correia T, Gibson A P, and Hebden JC (2009) "Identification of the optimal wavelengths in optical topography using photon density measurement functions".Proc. SPIE 7187, 718718 Full paper
  38. Gibson, A P, Dehghani, H (2009) "Diffuse optical imaging." Phil. Trans. Roy. Soc. A 367(1900) p3055-72 Full paper
  39. Dehghani H, Srinivasan S, Pogue, BW, Gibson, A P (2009) "Numerical modelling and image reconstruction in diffuse optical tomography". Phil. Trans. Roy. Soc. A367(1900) p3073-93 Full paper
  40. Panagiotou C, Somayajula S, Gibson A P, Schweiger M, Leahy R M and Arridge S R (2009) "Information theoretic regularization in diffuse optical tomography". J. Opt. Soc. Am. A26(5) p1277-1290 Full paper
  41. Correia T, Banga A, Gibson A P, Everdell N L, Hebden J C (2009) "A quantitative assessment of the depth sensitivity of an optical topography system using a solid dynamic tissue-phantom". Phys. Med. Biol. 54 6277-6286 Full paper
  42. Cooper RJ, Everdell NL, Enfield LC, Gibson AP, Worley A, Hebden, JC (2009) "Design and evaluation of a probe for simultaneous EEG and near-infrared imaging of cortical activation". Phys. Med. Biol. 54, 2093-2102. Full paper
  43. Price B D, Esbrand C J, Olivo A, Gibson A P, Hebden J C, Speller R D, Royle G J (2008) "Assessing the validity of modulation transfer function evaluation techniques with application to small area and scanned digital detectors" Rev. Sci. Instrum. 79 113103 Full paper
  44. Hebden J C, Correia T, Khakoo I, Gibson A P and Everdell N (2008) "A dynamic optical imaging phantom based on an array of semiconductor diodes" Phys. Med. Biol. 53 N407-N413 Full paper
  45. Hebden J C, Brunker J, Correia T, Price B D, Gibson A P, Everdell N (2008). "An electrically-activated dynamic tissue-equivalent phantom for assessment of diffuse optical imaging systems," Phys. Med. Biol. 53 p329-337 Full paper
  46. Leff D R, O J Warren, L C Enfield, A P Gibson, T Athanasiou, D K Patten, J C Hebden, G Z Yang, A Darzi (2008). "Diffuse optical imaging of the healthy and diseased breast: A systematic review" Breast Cancer Research and Treatment108 p9-22 Full paper
  47. Blasi A, Fox S, Everdell N C, Volein A, Tucker L, Csibra G, Gibson A P, Hebden J C, Johnson M, Elwell C. (2007). "Depth dependent changes in cerebral haemodynamics during face perception in infants"  Phys. Med. Biol. 52, 6849-6864. Full paper
  48. Enfield L C, Gibson A P, Everdell N L, Delpy D T, Schweiger M, Arridge S R, Richardson C, Keshtgar M, Douek M, Hebden J C (2007). "Three-dimensional time-resolved optical mammography of the uncompressed breast" Appl. Opt.46(17) p3628-3638 Full paper
  49. Nissilä I, J C Hebden, D Jennions, J Heino, M Schweiger, K Kotilahti, T Noponen, A P Gibson, S Järvenpää, L Lipiäinen, T Katila (2006). "A comparison between a time-domain and a frequency-domain system for optical tomography" J. Biomed. Opt.11 064015. Full paper
  50. Hebden J C, B D Price, A P Gibson, G Royle (2006). "A soft deformable tissue-equivalent phantom for diffuse optical tomography" Phys. Med. Biol. 51 p5581-5590. Full paper
  51. Austin T, A P Gibson, G Branco, R Md Yusof, S R Arridge, J H Meek, J S Wyatt, D T Delpy, J C Hebden (2006). "Three dimensional optical imaging of blood volume and oxygenation in the neonatal brain" Neuroimage 31(4) p1426-1433. Full paper. Preprint
  52. Gibson A P, E Cook, A Newing (2006). "Teaching Medical Physics" Phys. Educ. 41preprint
  53. Gibson A P, Austin T, Everdell N L, Schweiger M, Arridge S R, Meek J H, Wyatt J S, Delpy D T, Hebden J C (2006). "Three-dimensional whole-head optical tomography of passive motor evoked responses in the neonate" Neuroimage30(2) p521-528 preprint
  54. Yates T D, J C Hebden, A P Gibson, L Enfield, N L Everdell, S R Arridge, D T Delpy (2005). "Time-resolved optical mammography using a liquid coupled interface" J. Biomed. Opt.10(5) Full paper
  55. Everdell N L, Gibson A P, Tullis I D C, Vaithianathan T, Hebden J C, Delpy D T (2005). "A frequency multiplexed near-infrared topography system for imaging functional activity in the brain" Rev. Sci. Inst. 76 Full paper
  56. Gibson A P, J C Hebden, J Riley, N L Everdell, M Schweiger, S R Arridge, D T Delpy (2005). "Linear and non-linear reconstruction for optical tomography of phantoms with non-scattering regions." Appl. Opt 44, 3925-3936 Full paper
  57. Yates T D, J C Hebden, A P Gibson, N Everdell, S R Arridge, and M Douek (2005) "Optical tomography of the breast using a multi-channel time-resolved imager"Phys. Med. Biol.50 p2503-2517 Full paper
  58. Hebden J C, T D Yates, A P Gibson, N Everdell, S R Arridge, D W Chicken, M Douek, M R S Keshtgar (2005) "Monitoring recovery following laser surgery of the breast using optical tomography: a case study" Appl. Opt. 44(10), p1898-1904Full paper
  59. Tarvainen T, Kolehmainen V, Vauhkonen M, Vanne A, Gibson A P, Schweiger M, Arridge S R, Kaipio J P (2005). "Computational calibration method for optical tomography" Appl. Opt.44 (10) p1879-1888 Full paper
  60. Gibson A P, J C Hebden, S R Arridge (2005) "Recent advances in diffuse optical imaging" Phys. Med. Biol. 50 R1-R43 Full paper. This review has been highly cited.
  61. Vaithianathan T, I D C Tullis, N Everdell, T Leung, A P Gibson, J Meek, D T Delpy (2004). "The design of a portable near infrared system for topographic imaging of the brain in babies" Rev. Sci. Instrum. 75 (10) p3276-3283 Full paper
  62. Hebden J C, A P Gibson, T Austin, R Md Yusof, N Everdell, D T Delpy, S R Arridge, J H Meek, J S Wyatt (2004). "Imaging changes in blood volume and oxygenation in the newborn infant brain using three-dimensional optical tomography" Phys. Med. Biol.49(7) p1117-1130 Full paper
  63. Schweiger M, A P Gibson, S R Arridge (2003) "Computational Aspects of Diffuse Optical Tomography" Computing in Science and Engineering. Nov/Dec 2003 p33-41 Preprint
  64. Gibson A P, J Riley, M Schweiger, J C Hebden, S R Arridge, D T Delpy (2003). "A method for generating patient-specific finite element meshes for head modelling"Phys. Med. Biol.48 p481-495 Full paper. This paper nearly won a prize.
  65. Gibson A P, R Md Yusof, H Dehghani, J Riley, N Everdell, R Richards, J C Hebden, M Schweiger, S R Arridge, D T Delpy (2003). "Optical tomography of a realistic neonatal head phantom" Appl. Opt. 42(16) p3109-3116 Full paper
  66. Bagshaw A P, A D Liston, R H Bayford, A Tizzard, A P Gibson, A T Tidswell, M K Sparkes, H Dehghani, C D Binnie and D S Holder (2003). "Electrical impedance tomography of human brain function using reconstruction algorithms based on the finite element method" Neuroimage 20 p752-763 Full paper
  67. Hebden J C, F M Gonzalez, A P Gibson, E M C Hillman, R Md. Yusof, N Everdell, D T Delpy, G Zaccanti and F Martelli (2003). "Assessment of an in situ temporal calibration method for time-resolved optical tomography," J. Biomed. Opt. 8(1) p87-92 Full paper
  68. Hebden J C, A P Gibson, R Md Yusof, N Everdell, E M C Hillman, D T Delpy, S R Arridge, T Austin, J Meek, J S Wyatt (2002). "Three-dimensional optical tomography of the premature infant brain" Phys. Med. Biol. 47: 4155-4166 Full paper
  69. Tidswell A T, A P Gibson, R H Bayford and D S Holder (2001). "Three-dimensional Electrical Impedance Tomography of Human Brain Activity " Neuroimage 13p283-294 Full paper
  70. Tidswell A T, A P Gibson, R H Bayford and D S Holder (2001). "Electrical impedance tomography of human brain activity with a two-dimensional ring of scalp electrodes." Physiol. Meas. 22(1): 167-175 Full paper
  71. Tidswell A T, A P Gibson, R H Bayford and D S Holder (2001). "Validation of a 3D reconstruction algorithm for EIT of human brain function in a realistic head-shaped tank." Physiol. Meas. 22(1): 177-185 Full paper
  72. Bayford R H, A P Gibson, A Tizzard, T Tidswell and D S Holder (2001). "Solving the forward problem in electrical impedance tomography for the human head using IDEAS (integrated design engineering analysis software), a finite element modelling tool." Physiol. Meas. 22(1): 55-64 Full paper
  73. Gibson A P, R H Bayford and D S Holder (2000). "Two-dimensional finite element modelling of the neonatal head." Physiol. Meas. 21(1): 45-52. Full paper
  74. Gibson A P, R H Bayford and D S Holder (1999). "Development of a reconstruction algorithm for imaging impedance changes in the human head" Ann. N Y Acad. Sci.873: 482-92.
  75. Holder D S, C A Gonzalez-Correa, T Tidswell, A P Gibson, G Cusick and R H Bayford (1999). "Assessment and calibration of a low frequency system for electrical impedance tomography (EIT), optimised for use in imaging brain function in ambulant human subjects." Ann. N Y Acad. Sci. 873: 512-9.
  76. Giacometti, A., Terras, M. M., & Gibson, A. (2015). Objectively Evaluating Text Recovery Methodologies for Multispectral Images of Palimpsests.International Journal of Heritage in the Digital Era, 15th Issue dedicated to Computer Vision in Cultural Heritage.

Invited talks and papers

  1. Gibson AP (2012) "Optical image reconstruction" Functional near-infrared spectroscopy course, London UK, 26 Oct 2012
  2. Gibson AP (2012) "Optical mammography" Symposium Mammographicum, Harrogate, UK 3 Jul 2012
  3. Gibson AP (2011) "Translational proton research" IOP Meeting on Hadron Therapy, Manchester, UK 10 Jun 2011
  4. Gibson AP (2010) "Future possibilities for imaging breast tumours" RAD magazine,36 421 p29-30
  5. "Optical Tomography of the neonatal brain", UK-Japan Workshop on MultimodalMeasurements for Brain Function, Tokyo, Japan. 26-27 January 2010
  6. "Diffuse Optical Imaging of the breast" UK Radiological Congress, Manchester, UK. 9 Jun 2009
  7. "Diffuse Optical Imaging", IPEM Emerging Technologies in Diagnostic Imaging, London. 12 Feb 2008
  8. "Teaching Medical Physics", Institute of Physics Teachers' Update course, Cambridge, UK. 8 Dec 2007
  9. "Diffuse Optical Imaging", International Conference on Optics and Laser Applications in Medicine and Environmental Monitoring for Sustainable Development, Cape Coast, Ghana. 19 Nov 2007
  10. "Diffuse Optical Imaging" UK Radiological Congress, Manchester, UK.11 Jun 2007
  11. "Imaging the body using light", UCL Lunch hour lecture, London. 6 Feb 2007

Book Chapters

  1. Selb J and Gibson AP (2011) "Diffuse Optical Tomography: Time Domain" in "Handbook of Biomedical Optics" ed. D Boas, C Pitris, and N Ramanujam CRC Press

Selected conference proceedings

  1. Yerworth, R. J., Griffiths, J., & Gibson, A. (2016). The use of scenarios to contextualise, practice, and assess ‘soft’ skills. UCL Teaching and learning Conference 2016, UCL, London.
  2. Garcia-Souto P, Kane T, Hughes G, Searles-Bryant S and Gibson A (2016) Moderated peer assessment of individual contribution to group work. UCL Teaching and learning Conference 2016, UCL, London.
  3. Garcia-Souto P, Gibson A and Dewitz J (2016) Real-time feedback and personalized training for complex technical problems. UCL Teaching and learning Conference 2016, UCL, London.
  4. Terras, M. M., Graham-Matheson, H., Furlong, G., Wright, S., Makin, K., & Gibson, A. (2015). Collaborative Digitisation: UCL’s Medieval Manuscript Fragment Project.
  5. Dempsey LA, Cooper RJ, Powell S, Edwards A, Lee CW, Brigadoi S, Everdell N, Arridge S, Gibson AP, Austin T, Hebden JC. (2015). Whole-head functional brain imaging of neonates at cot-side using time-resolved diffuse optical tomography. Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 9538. doi:10.1117/12.2190420
  6. Garcia-Souto P, Hughes G, Tughral U, Yerworth R, Gibson A (2015) 360 degree peer assessment: improving reliability and engagement. UCL Teaching and learning Conference 2015, UCL, London.
  7. Yerworth R, Gibson A, Garcia Souto P (2015) Focusing the general: putting the heart in an introductory biomedical engineering module. UCL Teaching and learning Conference 2015, UCL, London.
  8. Vanhoestenberghe A, Garcia Souto P, Yerworth R, Gibson A (2015) Teamwork and communication in scenario-based learning: a case study in Biomedical Engineering. UCL Teaching and learning Conference 2015, UCL, London.
  9. Helo Y, Rosenberg I, Kacperek A, D'Souza D, MacDonald L, Dixon E, Speller R, Royle G & Gibson A (2014) Cerenkov optical emissions in particle radiotherapy Optical Society of America BIOMED conference BM4A.6, Miami 26-30 April 2014
  10. Proverbio A, Siow B, Alexander D, Hebden JC, Gibson AP (2014) Combined diffuse scatter spectroscopy and diffusion NMR for quantitative characterization of microstructure Optical Society of America BIOMED conference BT3A.40, Miami 26-30 April 2014 
  11. Giacometti, A., Gibson, A., Hess, M., Hindmarch, J., Macdonald, L., Pal, K., Weyrich, T. (2014). Heritage Imaging at UCL. Annual Conference of Association for Historical and Fine Art Photography (AHFAP).
  12. Proverbio A, Siow BM, Gibson AP, Alexander DC (2013). Multimodality characterization of microstructure by the combination of diffusion NMR and time domain diffuse scattering spectroscopy. ISMRM, Cambridge UK.
  13. MacDonald L, Giacometti A, Weyrich T, Terras M, Gibson AP (2013). "Colour Analysis of Degraded Parchment". Congress of the International Colour Association (AIC), Newcastle, July 2013.http://benchcom.co.uk/img/BookofAbstracts.pdf.
  14. Magdeldin T,Nyga A,Asghari A,Welch H,Loizidou M,Cheema U,Ricketts K,Gibson A,Royle G,Guazzoni C,Castolidi A,Montemurro G (2013) "Imaging gold nanoparticles in a novel tissue engineered 3d in vitro cancer model" BRITISH JOURNAL OF SURGERY, 100, 43 - 43.
  15. Campagnolo A,Giacometti A,MacDonald L,Mahony S,Terras M,Robson S,Weyrich T,Gibson A (2013) "Documenting and Interpreting Parchment Deterioration by Visual Analysis and Multispectral Imaging" Icon PF13, Positive Futures in an Uncertain World.
  16. Hebden, J. C., Varela, M., Magazov, S., Everdell, N., Gibson, A., Meek, J., & Austin, T. (2012). Diffuse optical imaging of the newborn infant brain. ISBI, 503-505. IEEE. doi:10.1109/ISBI.2012.6235595
  17. Proverbio, A., Siow, B., Lythgoe, M., Gibson, A., & Alexander, D. (2012).Multimodality investigation of microstructure: the combination of diffusion NMR and diffuse optical spectroscopy. Swansea: BMVA.
  18. Hebden JC, Cooper RJ, Gibson AP, Everdell N, Austin T (2012) Simultaneous EEG and diffuse optical imaging of seizure-related hemodynamic activity in the newborn infant brain Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 8427.
  19. Giacometti, A., Campagnolo, A., MacDonald, L., Mahony, S., Terras, M., Robson, S., Gibson, A. (2012). Cultural heritage destruction: Documenting parchment degradation via multispectral imaging. Proc. of Electronic Visualisation and the Arts (EVA 2012), 301-308.
  20. Alejandro Giacometti, Alberto Campagnolo, Lindsay MacDonald, Simon Mahony, Melissa Terras, Stuart Robson, Tim Weyrich, and Adam Gibson. "Cultural Heritage Destruction: Documenting Parchment Degradation via Multispectral Imaging". June 22ns 2012, Digital Classicist & Institute of Classical Studies Seminar, Summer 2012. Senate House, London.
  21. Pepper K, Ozkan C, Christodoulou C, Dreossi D, Castoldi A, Guazzoni C,  Gibson AP, Royle GJ (2012) "X-ray edge subtraction imaging of gold nanoparticle concentrations for biological imaging". IEEE Nuclear Science Symposium Conference Record 2877 - 2879.
  22. Castoldi A, Guazzoni C, Pepper K, Gibson A, Griffiths J, Royle GJ, Bjeoumikhov (2012) "2-D energy-resolved imaging of gold nanoparticle distribution at concentrations relevant for in-vitro studies" IEEE Nuclear Science Symposium Conference Record 261-265
  23. Eadie L, Taylor P, Gibson AP (2011) "A systematic review of computer assisted diagnosis used in mammography" Computer assisted radiology and surgery,Berlin, Germany, 22-25 Jun 2011
  24. Giacometti, A., Terras, M., Gibson, A., and Mahony, S. "Multi-Spectral Image Processing Methods For Analysing Ancient Documents". Paper presented at the Society for Digital Humanities / Société pour l’étude des médias interactifs (SDH/SEMI) annual conference at the 2011 Congress of the Social Sciences and Humanities. University of New Brunswick and St. Thomas University, Fredericton. May 28 -June 1, 2011.
  25. Enfield LC, Cantanhede G, Gibson AP, Hebden JC, Douek M, Purushotham A (2010) "Monitoring Primary Medical Therapy with Three-Dimensional Optical Mammography". Cancer Research 70(24 Suppl) p364s
  26. Pepper K, Christodoulou C, Guazzoni C, Castoldi A, Ozkan C, Griffiths JA, Gibson AP, Royle GJ (2010) "A System for X-ray Diffraction and Fluorescence Imaging of Nanoparticle Biomarkers" IEEE Nuclear Science Symposium, Medical Imaging Conference, Knoxville, Tennessee 30 Oct - 6 Nov 2010
  27. Eadie L, Taylor P, Gibson AP (2010) "Changes in performance of computer-assisted diagnosis and cancer imaging over time" IADIS International Conference e-Health  Freiburg 29-31 July 2010
  28. Cooper R, Austin T, Everdell N, Gibson AP, Hebden JC (2010) "Simultaneous EEG and Near‐Infrared Imaging for Investigation of Neurovascular Coupling and Neonatal Seizure" OSA Biomedical Optics Topical Meeting Miami Beach 11-14 Apr 2010.
  29. Price B, Gibson AP, Royle GR (2010) "Dual-modality imaging of a compressible breast phantom with realistic optical and x-ray properties". Proc. SPIE
  30. Wong S, Robson S, Gibson, AP, Hebden, JC (2009) "Low cost real-time web-cam photogrammetry to determine the locations of optical topography sensors located on the human head". Remote Sensing and Photogrammetry Society Annual Conference 2009. Leicester, 8-11 September 2009
  31. Panagiotou C, Somayajula S, Gibson, A P, Schweiger M, Leahy R M, Arridge S R (2009) "Diffusion optical tomography using entropic priors" 6th IEEE International Symposium on Biomedical Imaging. Boston MA, 28 Jun-01 Jul 1009.
  32. Price B, A P Gibson, J C Hebden, G Royle (2008). "Development Of Combined X-ray And Optical Mammography To Increase Specificity ". UK Radiological Congress Birmingham, UK 2-4 June 2008.
  33. Correia T, A P Gibson, J C Hebden (2008). "Optimal selection of the regularisation parameter for optical topography image reconstruction". OSA Biomedical Optics Topical Meeting St Petersburg, Florida. 16-20 March 2008
  34. Enfield L C, A P Gibson, N L Everdell, J C Hebden, S R Arridge, A Sharma, R Sainsbury, M Douek, M Keshtger (2008). "Sensitivity and specificity of 3D optical mammography". OSA Biomedical Optics Topical Meeting St Petersburg, Florida. 16-20 March 2008
  35. Gibson A P, L C Enfield, M Schweiger, S R Arridge, M Douek, J C Hebden (2008). "3D Optical mammography of the uncompressed breast". OSA Biomedical Optics Topical Meeting St Petersburg, Florida. 16-20 March 2008
  36. Morris N, J C Hebden, L C Enfield, A P Gibson, A Sharma, V Armstrong (2008). "How feedback from human subjects can enhance clinical performance of optical mammography". OSA Biomedical Optics Topical Meeting St Petersburg, Florida. 16-20 March 2008
  37. Abreu de Souza M, S Robson, J C Hebden, A P Gibson (2007). "Photogrammetric methods for acquiring accurate head surfaces for optical tomography monitoring of newborn infants". Remote Sensing and Photogrammetry Society, Annual Conference, Newcastle, September 2007
  38. Reid C, A P Gibson, J C Hebden V P Wallace (2007). "An oil and water emulsion phantom for biomedical terahertz spectroscopy". 4th IEEE-EMBS International Summer School and Symposium on Medical Devices and Biosensors (ISSS-MDBS 2007) Cambridge UK, Aug 2007
  39. Reid C, A P Gibson, J C Hebden V P Wallace (2007). "The use of tissue mimicking phantoms in analysing contrast in THz pulsed imaging of biological tissue". The Joint 32nd International Conference on Infrared and Millimetre Waves and 15th International Conference on Terahertz Electronics, Cardiff UK, Sept 2007
  40. Abreu de Souza M, S Robson, J C Hebden, A P Gibson, V Sauret (2006). "The photogrammetric determination of head surface shape and alignment for the optical tomography of newborn infants". International Society for Photogrammetry and Remote Sensing, Commission V, Dresden 25-27 September 2006
  41. Richardson CE, L Enfield, A P Gibson, N L Everdell, J C Hebden, S R Arridge, M R Keshtgar, R Sainsbury, M Douek (2006). "Non-invasive optical imaging in patients with breast cancer" European Society of Surgical Oncologists (ESSO) Conference, December 2006
  42. Gibson, A P, N L Everdell, J C Hebden, T Austin, F Wong, J H Meek, J S Wyatt, M Schweiger, S R Arridge (2006). "Anatomically constrained optical tomography of the neonatal brain" OSA Biomedical Topical Meeting, Miami
  43. Austin T, Gibson A P, Everdell N L, Schweiger M, Arridge S R , Meek J H, Wyatt J S, Hebden J C (2006). "Optical imaging of the neonatal brain". Neonatal Society, London
  44. Richardson C, L Enfield, A P Gibson, N L Everdell, J C Hebden, S R Arridge, D T Delpy, M Keshtgar, M Douek (2006). "Three-dimensional optical imaging of the breast" SET for Britain Poster presentation 13th March 2006 Highly Commended Award
  45. Richardson C E, L Enfield, A P Gibson, N L Everdell, J C Hebden, S R Arridge, D T Delpy, M Keshtgar, R Sainsbury, M Douek (2006). "Non-invasive three dimensional optical mammography" 8th Milan Breast Cancer Conference
  46. Richardson CE, L Enfield, A P Gibson, N L Everdell, J C Hebden, S R Arridge, D T Delpy, M Keshtgar, R Sainsbury, M Douek (2006). "Imaging Breast Cancer Non-invasively Using Three Dimensional Optical Tomography" British Association of Surgical Oncologists.
  47. Austin T, J C Hebden, A P Gibson, R Md Yusof, S R Arridge, J H Meek, D  Delpy, J S Wyatt (2005). Imaging 3D changes in blood volume and oxygenation in response to functional activation. European Society for Paediatric Research, Siena
  48. Gibson A P, T Austin, N Everdell, J Meek, J S Wyatt, M Schweiger, S R Arridge, D T Delpy, J C Hebden (2005). "3D optical tomography of the neonatal brain" Proc. SPIE preprint
  49. Becker W, A Bergmann, A P Gibson, N Everdell, D Jennions, M Schweiger, S R Arridge, J C Hebden (2005). "Multi-dimensional time-correlated single photon counting applied to diffuse optical tomography" Proc. SPIE 5693 p34-42. paper
  50. Hebden J C, A P Gibson, N Everdell, R Md Yusof, D T Delpy (2004). "Three-dimensional optical imaging of hemodynamic and oxygenation changes in the newborn infant brain" OSA Biomedical Topic Meetings, Miami
  51. Vilhunen T, V Kolehmainen, M Vauhkonen, A Vanne, J P Kaipio, A Gibson, M Schweiger, S R Arridge (2004). "Computational calibration method for optical tomography" OSA Biomedical Topic Meetings, Miami.
  52. Yates T D, J C Hebden, A P Gibson, S R Arridge, N L Everdell, M Douek, W Chicken, D T Delpy (2004). "Clinical results from a 32-channel time resolved system used to image the breast" OSA Biomedical Topic Meetings, Miami. poster
  53. Everdell N, A Gibson, I D C Tullis, T Vaithanian, J Hebden, D Delpy (2004). "A frequency multiplexed near infra-red topography system for imaging functional activation in the brain." OSA Biomedical Topic Meetings, Miami. Full abstract,poster
  54. Yusof R Md, J C Hebden, A Gibson, N Everdell, T Austin, J H Meek, S R Arridge, J S Wyatt, D T Delpy (2003). "Validation of the use of homogenous reference phantoms for optical tomography of the neonatal brain" SPIE Proc. "Optical Tomography and Spectroscopy of Tissue V" Vol. 4955, pages 6-11.
  55. Gibson A P, M Schweiger, J C Hebden, S R Arridge, D T Delpy (2003). "A method for generating patient-specific finite element meshes for head modelling" 4th Conference on Biomedical Applications of EIT, Manchester, 23-25 April 2003
  56. Gibson A, J Riley, M Schweiger, J C Hebden, S R Arridge, D T Delpy (2002). "Optical tomography of the neonatal head using a patient-specific finite element mesh". Computational Problems in Electrical Engineering, Zakopane, Poland.
  57. Gibson A, R Md Yusof, H Dehghani, J Riley, N Everdell, R Richards, J Hebden, M Schweiger, S Arridge, D T Delpy (2002). "Optical tomography of a realistic head-shaped phantom". OSA Biomedical Topic Meetings, Miami.
  58. Bland T, J Hebden, E M C Hillman, A Gibson, N Everdell, D T Delpy, S R Arridge, M Douek (2002). "Optical Tomography of the breast using a 32-channel time-resolved imager." OSA Biomedical Topic Meetings, Miami.
  59. Hebden J, E M C Hillman, A Gibson, N Everdell, R Yusof, D T Delpy, S R Arridge, T Austin, J H Meek (2002). "Time resolved optical imaging of the newborn infant brain: initial clinical results". OSA Biomedical Topic Meetings, Miami.
  60. A Gibson, L Eadie, R H Bayford, D S Holder (2001). "Optimum four terminal impedance measurements from the surface of a sphere." Biomedical applications of EIT, EPSRC 3rd Engineering Network meeting, London.
  61. Tidswell A T, A Gibson, A Liston, R J Yerworth, A Bagshaw, J Wyatt, R H Bayford, D S Holder (2001). "3D Electrical Impedance Tomography of Neonatal Brain Activity." Biomedical applications of EIT, EPSRC 3rd Engineering Network meeting, London.
  62. Liston A, R H Bayford, T Tidswell, A Gibson, D S Holder (2001). "Spherical reconstruction algorithms for EIT of human brain function in a realistic head shaped tank." XI International Conference on Electrical Bio-Impedance. Oslo. p397-401. ISBN 82-91853-05-3.
  63. Gibson A, A T Tidswell, R H Bayford, D S Holder (2000). "Finite element modelling of the human head in electrical impedance tomography", Simulation and Modelling Applied to Medicine II, London.
  64. Gibson A, A T Tidswell, R H Bayford and D S Holder (2000). "Realistic and spherical head models in EIT", World Congress on Medical Physics and Biomedical Engineering, Chicago.
  65. Tidswell A T, A Gibson, R H Bayford and D S Holder (2000). "Electrical Impedance Tomography of Human Brain Activity", World Congress on Medical Physics and Biomedical Engineering, Chicago.
  66. Bayford R, A Gibson, A Tizzard, D Holder (2000). "Modelling impedance changes in the human head using IDEAS", World Congress on Medical Physics and Biomedical Engineering, Chicago.
  67. Gibson A, A T Tidswell, R H Bayford and D S Holder (1999). "A 3D reconstruction algorithm for imaging impedance changes in the human head." Biomedical Applications of EIT, London, UK.
  68. Tidswell A T, A Gibson, R H Bayford and D S Holder (1999). "3D electrical impedance tomography of human brain activity". British Society for Clinical Neurophysiology Scientific Meeting, London, UK.
  69. Tidswell T, A Gibson, R Bayford and D S Holder (1999). "Scalp impedance changes during evoked responses in humans: implications for neuroimaging with electrical impedance tomography". The Physiological Society, London, UK.
  70. Gibson A, S Somaroo, R H Bayford and D S Holder (1998). "Development of a reconstruction algorithm for imaging impedance changes in the human head". X International Conference on Electrical Bioimpedance, Barcelona.
  71. Gibson A, R Bayford and D Holder (1997). "The effect of skull impedance on electrical impedance tomography of the neonatal head." Med. & Biol. Eng. & Comp. 35(1): 328.
  72. Rao A, A Gibson and D S Holder (1997). "EIT images of electrically induced epileptic activity in anaesthetised rabbits." Med & Biol. Eng & Comp. 35(1): 327.
  73. Gibson A, D Follett, I Summers and M Halliwell (1996). "Long term monitoring and analysis of arterial blood flow". IPEMB Second Annual National Conference, Leeds, UK

PhD thesis

 

PhD Thesis: Electrical Impedance Tomography of Human Brain Function

Abstract

This thesis shows for the first time that Electrical Impedance Tomography (EIT) is able to detect and image changes in impedance during brain activity in humans. The work described is both experimental and theoretical.

In the first instance, the sources of artefacts in EIT images were investigated. Although an impedance change could be correctly localised, both increases and decreases in impedance were present. The characteristics of the impedance change were examined by measuring the impedance change directly.

Following this, a reconstruction technique was developed, designed for imaging the human head in 3D. The head was modelled as a homogeneous sphere and images reconstructed from this were tested using simulated data and data obtained in saline-filled tanks.

This algorithm was then used to generate images from EIT data recorded during evoked responses in human volunteers. Although images reconstructed from saline-filled tanks were able to localise an impedance change accurately, images reconstructed from human data localised the impedance change correctly in around a half of the experiments.

The possibility that the incorrect localisation was due to modelling errors was investigated by incorporating a finite element model of a real human head into the reconstruction process. The results from this method were similar to those obtained using the spherical model of the head.

Details of the thesis are given below. 
- Please email me with details of your interests and I will send you a copy in pdf format.

Preliminaries

- Title page, table of contents, acknowledgements, etc.

Introduction

- Background. EIT instrumentation, image reconstruction, applications of EIT, some physiology and the potential use of EIT in brain imaging.

A Reconstruction algorithm for a sphere

- Development of a 3D linearised reconstruction technique for brain imaging, assuming the head can be modelled as a homogeneous sphere. Discusses optimum electrode placement, an analytical calculation of the sensitivity matrix and matrix inversion by singular value decomposition. The technique is validated on simulated data and data acquired from saline-filled tanks.

Impedance imaging of human evoked responses

- Describes the human imaging protocol and modifications to the image reconstruction technique. Some results, including images, are presented, and there is a detailed discussion of possible sources of error.

Inclusion of real head model

- A realistic finite element model of the head was obtained and used to calculate the sensitivity matrix. Little improvement in image quality was seen in human imaging. Possible reasons for this are discussed.

Conclusion

- Progress made, future work and possible future prospects for impedance imaging of the brain.

Appendices

- Methods of imaging the brain, Solution to Poisson's Equation for a sphere and 2D finite element modelling of the neonatal head.

References