Jolly Lab



Tafhima Haider, Xenia Snetkov, Clare Jolly. HIV envelope tail truncation confers resistance to SERINC5 restriction. Proc Natl Acad Sci U S A. 2021 May 25;118(21):e2101450118. doi: 10.1073/pnas.2101450118.

Nathalie M Schmidt, Peter A C Wing, Mariana O Diniz, Laura J Pallet, Leo Swadling, James M Harris, Alice R Burton, Anna Jeffery-Smith, Nekisa Zakeri, Oliver E Amin, Stephanie Kucykowicz, Mirjam H Heemskerk, Brian Davidson, Tim Meyer, Joe Grove, Hans J Stauss, Ines Pineda-Torra, Clare Jolly, Elizabeth C Jury, Jane A McKeating, Mala K Maini. Targeting human Acyl-CoA:cholesterol acyltransferase as a dual viral and T cell metabolic checkpoint. Nat Commun. 2021 May 14;12(1):2814.doi: 10.1038/s41467-021-22967-7.

Jenny O'Nions, Luke Muir, Jiexin Zheng, Chloe Rees-Spear, Annachiara Rosa, Christopher Earl, Peter Cherepanov, Rajeev Gupta, Asim Khwaja, Clare Jolly, Laura E McCoy 'SARS-CoV-2 antibody responses in patients with aggressive haematological malignancies' MedRxiv

Mesner D, Hotter D, Kirchhoff F, Jolly C. Loss of Nef-mediated CD3 down-regulation in the HIV-1 lineage increases viral infectivity and spread. Proc Natl Acad Sci U S A. 2020 Mar 31;117(13):7382-7391. doi: 10.1073/pnas.1921135117. Epub 2020 Mar 16.

Titanji BK., Pillay D., and Jolly C. (2017). Combination antiretroviral therapy and cell-cell spread of wild-type and drug-resistant human immunodeficiency virusu-1. Journal of General Virology 98: 821-834.

Len AC., Starling S., Shivkumar M. and Jolly C. (2017) HIV-1 activates signaling independently of antigen to drive viral spread. Cell Reports 18: 1062-1074.

Starling S, Jolly C. LFA-1 Engagement Triggers T Cell Polarization at the HIV-1 Virological Synapse. J Virol. 2016 Nov 1;90(21):9841-9854. PubMed PMID: 27558417.

Zhang C., Zhou S., Groppelli E., Pellegrino P., Williams I., Borrow P., Chain B. and Jolly C. (2015) Hybrid spreading mechanisms and T cell activation shape the dynamics of HIV-1 infection. PloS Computational Biology. 11:e1004179

Groppelli E., Starling S. and Jolly C. (2015) Contact-induced mitochondria polarization supports HIV-1 virological synapse formation. Journal of Virology. 89: 14-24.

Groppelli E., Len A., Granger L., and Jolly C. (2014) Retromer regulates HIV-1 envelope glycoprotein trafficking and incorporation into virions. PLoS Pathogens 10:e1004518

McCoy L., Groppelli E., Blanchetot C., de Haard H., Verrips T., Rutten L., Weiss R. and Jolly C. (2014) Neutralisation of HIV-1 cell-cell spread by human and llama antibodies Retrovirology 11:83.

Titanji B., Aasa-Chapman M., Pillay D. and Jolly C. (2013) Protease inhibitors effectively block cell-to-cell spread of HIV-1 between T cells. Retrovirology 10: 161.

Wei B., Han L., Abbink T., Groppelli E., Lim D., Thaker Y., Gao W., Zhai R., Wang J., Lever A., Jolly C., Wang H. and Rudd C. (2013) Immune adaptor ADAP in T cells regulates HIV-1 transcription and cell-cell viral spread via different co-receptors. Retrovirology 10:101

Jolly C., Welsch S., Michor S. and Sattentau Q. (2011) The regulated secretory pathway in CD4+ T cells contributes to Human Immunodeficiency Virus type-1 cell-to-cell spread at the virological synapse. PLoS Pathogens 7, e10022226.

Zhou L., Sokolskaja E., Jolly C., James W., Cowley S. and Fassati A. (2011) Transportin 3 promotes a nuclear maturation step required for efficient HIV-1 integration. PLoS Pathogens 7, e1002194

Jolly C. (2011) Cell-to-Cell transmission of retroviruses: Innate immunity and interferon induced restriction factors. Virology 411: 251-259

Jolly C. (2011) T cell polarization at the Virological Synapse. Viruses 2: 1261-1278

Jolly C., Booth N. and Neil S. (2010) Cell-cell spread of human immunodeficiency virus type-1 overcomes tetherin/BST-2 mediated restriction in T cells. Journal of Virology 84: 12185-99

Gonzalez N., Bermejo M., Calinge E., Jolly C., Arenzana-Seisdedos F., Pablos J., Sattentau Q.J., Alcami J. (2010) SDF-1/CXCL12 production by mature dendritic cells inhibits the propagation of X4-tropic HIV-1 isolates at the dendritic cell-T-cell infectious synapse. Journal of Virology 84: 4341-51

Martin N., Welsch S., Jolly C., Briggs J., Vaux D., and Sattentau Q. (2010) Virological synapse-mediated spread of Human Immunodeficiency Virus Type-1 between T cells is sensitive to entry inhibition. Journal of Virology 84: 3516-27

Sowinski S., Jolly C., Berninghausen O., Purboo M., Chauveau A., Kohler K., Oddos S., Eissmann P., Brodsky F., Hopkins C., Onfelt B., Sattentau Q. and Davis D. (2008) Membrane nanotubes physically connect T cells over long distances presenting a novel route for HIV-1 transmission. Nature Cell Biology 10: 211-9

Jolly C., and Sattentau Q.J. (2007) Regulated secretion from CD4+ T cells. Trends in Immunology 28: 474-81

Jolly C., Mitar I., and Sattentau Q. (2007) Adhesion molecule interactions facilitate human immunodeficiency type-1 induced virological synapse formation between T cells. Journal of Virology 81: 13916-21

Jolly C., and Sattentau Q. (2007) Human immunodeficiency type-1 assembly, budding and cell-cell spread in T cells takes place in tetraspanin-enriched plasma membrane domains. Journal of Virology 81: 7873-84

Jolly C., Mitar I., and Sattentau Q. (2007) Requirement for an intact T-cell actin and tubulin cytoskeleton for efficient assembly and cell-cell spread of Human Immunodeficiency Virus Type-1. Journal of Virology 81:5547-60

Jolly C., and Sattentau Q. (2005) Human Immunodeficiency Virus type-1 virological synapse formation in T cells requires lipid raft integrity. Journal of Virology 79: 12088-94

Jolly C., Kashefi K., Hollinshead M., and Sattentau Q. (2004) HIV-1 cell to cell transfer across an Env-induced, actin-dependent synapse. Journal of Experimental Medicine 199: 283-93.