Jolly Lab


Jolly Lab

We aim to understand the cell biology of HIV-1 infection and spread between T cells, focussing on how HIV-1 hijacks the host T cell machinery to most efficiently replicate while evading antiviral defences. Dissecting the molecular details of how these processes work will provide greater insight into HIV-1 pathogenesis and inform future antiviral strategies. We are also working on SARS-CoV-2 virus-host interactions with emphasis on innate immunity.

Our current research focuses on the following main areas:

  •         Dissecting virus-host interactions that support successful HIV replication in T cells and understanding what makes a T cell permissive for HIV-1.
  •         Determining how HIV-1 reprograms T cells during infection and the implications for viral persistence and reservoir formation.
  •         Determining how SARS-CoV-2 VOCs have evolved to better suppress and evade human innate immune sensing and antiviral restriction factors.
  •         Evaluating antiviral therapeutics and inhibitors.

      We have teamed up with the Towers’ lab to study SARS-CoV-2 and its interaction with host cells, read more about our research here


       The Jolly Lab is funded by the Wellcome Trust.