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Our latest publication is available on MedRxiv, Oct 2020 

O'Nions et al 2020. Fig 1 Temporal dynamics and anti-viral function of SARS-CoV-2 antibody responses in haematological malignancy
Read about a new study we have been involved with in collaboration with clinicians at UCLH and colleagues in Infection and Immunity:

'SARS-CoV-2 antibody responses in patients with aggressive haematological malignancies' Jenny O'Nions, Luke Muir, Jiexin Zheng, Chloe Rees-Spear, Annachiara Rosa, Christopher Earl, Peter Cherepanov, Rajeev Gupta, Asim Khwaja, Clare Jolly, Laura E McCoy

 

 


 

The Jolly lab has re-opened for SARS-CoV-2 work, April 2020

Dr Clare Jolly investigates SARS-CoV-2. (photo courtesy of Nick David www.nickdavid.co.uk)

Dr Ann-Kathrin Reuschl trains researchers in SARS-CoV-2 work, 2020 (photo courtesy of Nick David www.nickdavid.co.uk)

We are working closely with the Towers, Selwood and Noursadeghi labs (UCL) to address the following questions:
 
·         How does the virus trigger innate and proinflammatory responses across different cell types in vitro?
·         Which pathways lead to proinflammatory cytokine secretion and cell death, as observed in severe COVID-19 patients?
·         How do the responses observed in vitro compare to those seen in vivo?
·         How do the innate responses influence immune crosstalk and T cell functions associated with immunopathology in severe COVID-19 patients?
·         Can we identify specific pathways and inhibitors to modulate innate and immune crosstalk to reduce pro-inflammatory responses and cell death?
·         Which viral proteins activate or antagonise innate responses?
·         Which restriction factors target SARS-CoV-2 and do these contribute to innate immune signalling?
 
We have been busy supporting the work of other groups at UCL by getting our CL3 labs operational for SARS-CoV-2, and training and supervising new users:

Dr Clare Jolly trains researchers in SARS-CoV-2 work, 2020 (photo courtesy of Nick David www.nickdavid.co.uk)

Dr Ann-Kathrin Reuschl trains researchers in SARS-CoV-2 work, 2020 (photo courtesy of Nick David www.nickdavid.co.uk)

 


Dejan's paper is published in Proceedings of the National Academy of Sciences of the United States of America, March 2020

Mesner D, Hotter D, Kirchhoff F, Jolly C. Loss of Nef-mediated CD3 down-regulation in the HIV-1 lineage increases viral infectivity and spread. Proc Natl Acad Sci U S A. 2020 Mar 31;117(13):7382-7391. doi: 10.1073/pnas.1921135117. Epub 2020 Mar 16.


Clare presented at the 1st Max Planck Society Workshop on HIV Reservoirs and Evolution in St Lucia, South Africa. January 2019

Dr Clare Jolly pesents at the 1st Max Planck Society Workshop on HIV Reservoirs and Evolution, St Lucia, South Africa

Elephant spotting on safari following the 1st Max Planck Society Workshop on HIV Reservoirs and Evolution, St Lucia, South Africa.

 

Clare presented on 'Cell - Cell spread of HIV-1' and rounded the conference off with a safari with Greg, Ravi, and Laura.


Infection and Immunity's Christmas Party, December 2018

Awesome evening captured by AK. The Infection and Immunity Christmas Party 2018
Infection and Immunity celebrated Christmas at the Lexington

 

Jolly Lab Retreat in Amsterdam with the Towers Lab, December 2018

Towers and Jolly Labs on retreat in Amsterdam 2018
A great week of productive science, discussion, team building and expanding horizons.
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The Jolly lab group photo, Amsterdam. December 2018
To view the gallery of our adventure go the the Towers retreat 2018 gallery.

We attended the Frontiers of Retrovirology conference in Leuven, Belgium, September 2018.

Frontiers of Retrovirology conference in Leuven, Belgium
The Jolly lab went to the Frontiers of Retrovirology conference in Leuven, Belgium where some of the lab presented their recent work.

 

Jolly Lab win at the Feathers pub quiz, 2018                                             

A win for the Jolly lab at the Feathers pub quiz

The Lab was at the the 10th Blizard Institute HIV Symposium, June 2018

10th Blizard HIV Symposium, Barts London

Setting up the draw for the department World Cup sweepstake, 2018

Setting up the draw using agar plates for the department world cup sweepstakeThe department was swept up in World Cup fever thanks to an ingenious system devised by the Jolly lab of countries written on agar. You have to grow your bacteria to see who you drew!

Microbiology Society Conference, 2018                                                        

The Jolly lab attends the Microbiology Society Conference, 2018
The Jolly lab presented at the annual Microbiology Society Conference.

Infection and Immunity divisional Christmas Party, December 2017

The Jolly Lab at the 2017 Infection and Immunity divisional party

 

 

 

Christmas celebrations with the Towers lab at 'Watch Me', December 2017

Christmas celebrations with the Towers lab
The annual Chriatmas curry.

WOHL Christmas Dinner, December 2017                                        

WHOL Christmas dinner
You can never have too many Christmas celebrations!

 

Halloween celebrations with the Towers lab, October 2017                              

The Jolly lab at the Towers lab Halloween partyHalloween dressing up - a character that shares your initails......

Towers lab picnic in Regent's Park, August 2017

Towers lab picnic in Regent's Park 2017
Bathed in Sunshine. The Towers lab summer picnic in Regent's park.

 

 

Our Latest Paper is Published in Cell Reports, 2017.

The Jolly lab has had their paper “HIV-1 activates T cell signaling independently of antigen to drive viral spread” published in Cell Reports.
The Jolly lab has had their paper “HIV-1 activates T cell signaling independently of antigen to drive viral spread” published in Cell Reports.

 

Infection and Immunity Christmas Party, December 2016

The Jolly Lab at the 2016 Infection and Immunity divisional partyLooking good at Infection and Immunity's Christmas party.

 

WOHL Christmas dinner, 2016

WHOL Christmas dinner

Dr Shimona Stirling leaves the Jolly lab, 2016

Dr Shimona Stirling leaves the Jolly lab for a post at Nature
Shimona has left the Jolly lab to take up an editorial post at Nature.

 

Towers lab picnic in Regents Park, August 2016

Towers lab picnic in Regent's Park 2016
Another year, another picnic in the sun in Regent's Park. The Jolly lab were well represented in the football.

 

Two generations of HIV scientists meet, 2016

Two generations of HIV scientists meet: Members of the Jolly lab with Françoise Barré-Sinoussi after the UCL Prize Lecture for Clinical Science 2016
Members of the Jolly lab with Françoise Barré-Sinoussi after the UCL Prize Lecture for Clinical Science 2016

Shimona Starling wins 1st prize at the Colloquium, 2015

Shimona Starling won 1st prize at the PhD colloquim
Congratulations to our PhD student  Shimona Starling who won first prize in the poster competition at the 2015 UCL Division of Infection and Immunity PhD student Colloquium.

Clare Secures a further 5 years funding, 2015

Dr Joe Grove, Prof Greg Towers, Prof Ravi Gupta and Dr Clare Jolly celebrate their Wellcome Trust awards.
Congratulations to Clare who has secured  a Wellcome Trust Investigator Award for her work on "Virus-Host interactions regulating HIV-1 replication in T cells" funding her lab for a further 5 years.

Celebrations were held in the UCL Quad to congratulate Clare along with Dr Joe Grove, Prof Greg Towers and Dr Ravi Gupta who all secured Wellcome Trust grants.

Clare's Image on the cover of Journal of Virology, Jan 2015

Dr Clare Jolly's image graces the cover of the Journal of Virology, Jan 2015

Elisabetta Spent 6 weeks in Sierra Leone, Feb 2015

Sample reception at the Ebola diagnostic laboratory, Port Loko, Sierra Leone
Elisabetta was seconded to Public Health England to be part of a team of scientists working in the Ebola diagnostic labs helping to end the outbreak in West Africa.

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