Professor Sir Peng Khaw
Professor of Glaucoma Studies and Wound Healing
Institute of Ophthalmology
Faculty of Brain Sciences
- Joined UCL
- 1st Oct 1993
Professor Sir Peng Tee Khaw’s laboratory group carry out research into the basic biology of healing, with a view to developing new treatments for the prevention of scarring and regeneration of tissues after ocular surgery and disease. They have designed specific single applications of intra-operative antimetabolites, which has led to the 'More Flow Regimen' and long term clinical trials in UK, the Far East and Africa. These trials have shown prospectively for the first time that progression after field and disc change can be almost completely stopped by the control of scarring and maximal pressure lowering.
He has developed the ‘Moorfields Safer Surgery System’. The change in surgical technique of antimetabolite application has led to a dramatic reduction in antimetabolite bleb related complications (>75% reduction in blebitis and endophthalmitis) and has been widely adopted around the world. This received a highest research impact score at the last REF exercise. He has continued to refine surgical techniques introducing new techniques such as the ‘adjustable’ suture to titrate intraocular safely downwards. He has proposed the the 10 10 10 audacious goal for glaucoma surgery - a pressure of 10 mmHg, lasting at least 10 years and delivered in 10 minutes. This multidisciplinary project is currently underway.
A Moorfields trial has also shown a significant reduction in postoperative retinal scarring after detachment surgery (the first trial in the world to show this). They are also developing further improved surgical techniques for glaucoma surgery, and new anti-scarring treatments based on modern biotechnology. They are developing different methods of modifying cellular contractile and matrix modulating activity with small molecules for the prevention of scarring in the cornea, conjunctiva, lens capsule and the retina in the eye, and in other parts of the body. They are developing this treatment for human use with one of the first UK Medical Research Council Developmental Pathway Translational Awards and a new drainage device supported by the NIHR i4i Award, together with Professor Steve Brocchini and Dr Maryse Bailly.
They have also popularised the concept that the prevention of fibrosis may open the door to regeneration in the human body. His group also collaborate in research into stem cells including a line of multipotent stem cells in the adult retina that can de-differentiate into various cells of the retina and help maintain vision in a model of retinal blindness. They are also working on projects to regenerate function of the optic nerve using stem cells with Professors Astrid Limb and Geoff Raisman, resulting in the recent "energy" theory of glaucoma based on astrocytic-axon disinsertion leading to axonal and ganglion cell body death with the subsequent collapse of the nerve head. This has led to new approaches to rescue neuroaxonal function in glaucoma.
Professor Sir Peng Tee Khaw has helped raise research and infrastructure grants of over £120 million, including the new £20 million Moorfields International Children’s Eye Centre, for which he was the main clinical fundraiser. He headed the application for and is the director of the NIHR Biomedical Research Centre in Ophthalmology, which includes a new NIHR Clinical Research Facility and Translational Research Clinical Centre (TRACC) to ‘fast track’ new clinical therapies, an NIHR early phase unit, and the Weston Functional testing centre.
Professor Sir Peng Khaw passionately believes that scientific research will enable us to achieve new and better treatments to prevent ocular scarring, and to ultimately promote regeneration of tissues to prevent and treat blindness around the world.
Previous responsibilities have included organising courses, teaching and giving lectures to/at:
International courses - USA American Academy of Ophthalmology, World Glaucoma Congress, European Glaucoma Congress
Masterclass Glaucoma: Royal College of Ophthalmologists
British Council Course on Paediatric Ophthalmology and MSc in Preventive Ophthalmology
National Courses: Chair UK Glaucoma Professionals Course
Postgraduate centres in the UK: Including Birmingham, Bristol, Cambridge, Dundee, Glasgow, Leeds, Liverpool, Manchester, Newcastle, Nottingham, North West and South West Thames meetings, Oxford, Sheffield and Southampton.
MRCP: UK Courses.
DO and FRCS, MRCOphth and FRCOphth candidates: At weekly postgraduate teaching sessions at Southampton and also the UCL Institute of Ophthalmology MRCOphth and other Masters courses. I have also taught on the Royal College of Ophthalmologists glaucoma course, and regularly teach at the weekly Glaucoma Unit teaching session for residents and fellows.
Medical students: I introduced a student assessment system while lecturer at Southampton and also a system for the students to assess the teachers. Voted best taught course by students.
Other groups including general practitioners: Wessex General Practitioner Trainees, National Community Physiotherapists, National Theatre Sisters, Wessex Operating Department Assistants, Moorfields general and theatre courses, British Association of Young Optometrists, British Association of Young Scientists, Annual Paediatric Ophthalmology Conference, Annual Royal College of Ophthalmologists, North Thames Regional Study Group, London Deanery School of Ophthalmology Conference and Academy of Medical Sciences Conference for young doctors.
(Current) European School of Advanced Studies in Ophthalmology (ESASO) (Co-chair) on Wound Healing and Pediatric Glaucoma & Research
- University College London
- PhD, Medicine | 1994
- University of Southampton
- BM, Clinical Medicine | 1980
Professor Sir Peng Tee Khaw is Professor of Glaucoma and Ocular Healing at the UCL Institute of Ophthalmology and Consultant Ophthalmic Surgeon at Moorfields Eye Hospital, London UK. He is also Director of the National Institute for Health Research Specialist Biomedical Research Centre in Ophthalmology at Moorfields Eye Hospital and UCL Institute of Ophthalmology; Director of Research and Development at Moorfields Eye Hospital; President of the UK Paediatric Glaucoma Society; and an NIHR Senior Investigator since 2009.
Professor Sir Peng Tee Khaw has a special interest in the surgical and medical treatment of the refractory glaucomas, particularly paediatric glaucoma. His group undertakes research into new surgical techniques and new treatments to prevent scarring and encourage regeneration of tissues after ocular surgery and disease. They have developed inexpensive single applications of intra-operative antimetabolites that have been tested in clinical trials across the world, and have also developed new surgical techniques, including the Moorfields Safer Surgery System, dramatically reducing bleb related and other complications, now used worldwide. They are developing drug delivery systems, stem cell therapies and new single application anti-scarring treatments.
Professor Sir Peng Tee Khaw has delivered over 35 national and international named lectures, won over 12 prizes & awards including the first international ARVO Pfizer Translational Medicine Prize. He was the first UK President of the Association for Research in Vision and Ophthalmology (ARVO, 2012-2013). He has raised grants of over £120 million, including funding for the world’s largest Children’s Eye Hospital and translational research clinical centre, and was knighted in the Queen’s Birthday Honours for 2013 for services to ophthalmology, one of two ophthalmologists in the last century. He passionately believes that scientific research will enable us to achieve new and better treatments to changes lives for the better.