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UCL Institute of Ophthalmology

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Dr Silvia Dragoni

Dr Silvia Dragoni

Research Associate

Institute of Ophthalmology

Faculty of Brain Sciences

Joined UCL
23rd Mar 2015

Research summary

Throughout my career my research has focused on studying endothelial cells in physiological and pathological conditions and the regulatory role of Vascular Endothelial Growth Factor (VEGF).

Currently, I am working on VEGF-induced permeability in the blood-brain and blood-retinal barriers. I have validated an ex-vivo retinal model in rats to measure acute permeability in the retina in real time. I established this model in mice for the first time and I am using it successfully to elucidate the VEGF pathway that leads to permeability in the brain and the retina. The aim of my future work is to dissect the leakage response and associated signalling mediated by VEGFR2 in neural endothelial cells depending in its intracellular localisation, dimerization status and association with co-receptors or distinct signalling platforms.

Teaching summary

2008 - 2010: Tutor of human anatomy for BSc students at the University of Pavia, Italy – 20 hours of teaching/year

Education

Universita degli Studi di Pavia
, | 2014
Universita degli Studi di Pavia
, | 2010
Universita degli Studi di Pavia
, | 2008
Publications