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UCL Institute of Ophthalmology

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Dr Alice Davidson

Senior Research Associate

Institute of Ophthalmology

Faculty of Brain Sciences

Joined UCL
1st Feb 2010

Education

University of Manchester
, | 2010
University of Manchester
, | 2006

Biography

Alice started her scientific research career at The University of Manchester (UK), where she undertook a PhD in Molecular Genetics and Cell Biology investigating the role of bestrophin-1 in ocular disease. Her doctoral studies made a significant contribution to the field by elucidating underlying disease mechanisms, deciphering phenotype-genotype correlations and expanding the phenotypic spectrum of diseases. Her first postdoctoral position, at UCL Institute of Ophthalmology (IoO) UK, focused on identifying novel genetic causes of autosomal recessive retinal diseases by exploiting homozygosity mapping of consanguineous pedigrees and new developments in next generation sequencing methods. Alice’s research contributed to the identification of 6 novel genetic causes of ocular conditions including Leber’s congenital amaurosis, benign fleck retina and retinitis pigmentosa.


Alice subsequently undertook a second postdoctoral position at UCL IoO investigating the genetics of complex and monogenic corneal diseases, investigating a diverse range of conditions including keratoconus, X-linked megalocornea, epithelial recurrent erosion dystrophy and TGFBI-associated dystrophies. She developed a special interest in the genetic causes and molecular mechanisms underlying inherited corneal endothelial dystrophies (CEDs), and was awarded a Fight for Sight Early Career Investigator fellowship in 2015 to initiate her own independent research program at UCL IoO to focus on this area. Currently, her research program aims to understand the genetic origins of this disease group, which ranges from dominant polymorphous corneal dystrophy (PPCD) to the more common age-related condition Fuchs corneal endothelial dystrophy (FECD). She translates her genetic discoveries to understanding the pathophysiology of CEDs and developing novel diagnostic approaches and therapeutic strategies for patients with CEDs.

 

Publications