UCL IoO at ARVO 2024

The ARVO Annual Meeting is the premiere gathering for eye and vision scientists from across the globe, at all career stages, students and those in affiliated fields to share the latest research findings and collaborate on innovative solutions. It is a showcase of new research and the opportunity to network with colleagues and industry thought-leaders.

The theme this year addresses how vision research is continually being transformed by new information and technologies.

The event takes place at the Seattle Convention Centre. Please check the ARVO website for details. Links provided on this page.

Sunday 5 May

Talks

• 8.45- 9am
  Pearse Keane: Transforming Ophthalmology with AI - Going from code to clinic
• 9.00 - 9.19am
  Rachael Pearson: Advancing stem cell-derived photoreceptor replacement therapy
• 2:15 - 2:30pm 
  Konstantinos Balaskas: The SD-OCT correlates of fundus autofluorescence in geographic atrophy: a comprehensive point-to-point analysis of fundus autofluorescence with SD-OCT using phase 3 trials DERBY and OAKS
• 3.15-3.30pm
  Vijay Tailor: Visual crowding in infantile idiopathic nystagmus is not reduced by contrast-polarity differences or flicker.
• 3:30 - 3:45pm
  Anthony Khawaja: Cross-ancestry genome-wide association study for intraocular pressure in 263,134 individuals provides novel insights into glaucoma pathogenesis
• 3.30 - 3.45pm
  Pirro Hysi: A metabolome-wide analysis of Intraocular pressure suggests neuroinflammatory mechanisms as possible mechanisms involved in glaucoma
• 3.30 - 3.46pm
  Robert Henderson: Interim results for RGX-381: a first in human phase 1/2 clinical trial of AAV.CB7.hCLN2 gene therapy for CLN2 Batten disease-associated retinopathy
• 4.00 -4.15pm
  Kelsey Vernon Stuart: Association of socioeconomic status, polygenic risk, and glaucoma
• 4:15 - 4:30pm
  Paul Foster: Association of Ambient Particulate Matter (PM2.5) Exposure and Glaucoma Incidence: A Prospective UK Biobank Study
• 4:30 -4:45pm
  Evangeline Monroe Foster: Development of a novel in vitro platform to model the involvement of the immune system in AMD.

Poster presentations 

• 8:00 - 9:45am
  Ashkon Seyed-Safi A0033: Human serum-derived extracellular vesicles support corneal epithelial wound healing in vitro
• 1:00 - 2:45pm 
  Katy Linkens A0488: Choroideremia iPSC-RPE model reveals a dysregulated inflammatory response
  Nihar Bhattacharyya A0505: Spatial transcriptomics reveal isoform-specific patterns of TCF4 dysregulation in CTG18.1 expansion positive FECD case-derived corneal endothelial cells
  Aleksandra Goch B0570: User Interface for Bimanual Robotic System in Posterior Segment Surgery – Survey Study
• 3:15 - 5:00pm
  Olivia Farah Rezek B0160: In vitro modelling of autosomal dominant Doyne honeycomb retinal dystrophy caused by the p.R345W EFEMP1 mutation and development of a gene-directed therapeutic

Monday 6 May

Talks 

• 9:00 - 9:15am
  Hannah Dunbar: The prognostic power of baseline visual function deficits in intermediate age-related macular degeneration (iAMD) for progression to late AMD - A MACUSTAR study report 
• 9:30 - 9:45am
  Siying Lin: Non-syndromic retinal dystrophy associated with biallelic mutation of SUMF1 and reduced leukocyte sulphatase activity
  Ines Drira: Oculomics in Bipolar Affective Disorder: Insights from Retinal Imaging
  Ahmed Ellabban: Exploring kinetics of the ganglion cell contribution to standard light-adapted flash electroretinograms by interocular comparison in patients with unilateral ganglion cell loss
• 3.15pm
  Freddie Braddock: A novel autosomal dominant Corneal Stromal Dystrophy associated with a SPARCL1 missense variant
• 3:30 - 3:45pm
  Sobha Sivaprasad: BCVA gains with aflibercept 8 mg maintained through Week 96 in PULSAR with extended treatment intervals in patients with nAMD
• 4:15 - 4:30pm
  Roxanne Crosby-Nwaobi: Promoting ophthalmic research in underserved communities.

Poster presentations

• 8:30 - 10:15am 
  Evangelia Chalkiadaki: B0307: Real-world outcomes of a Ranibizumab biosimilar product (Ongavia) in neovascular age related macular degeneration (nAMD) patients
  Zaynab Butt:  A0004: Investigating allele-specific CRISPR/Cas9 gene editing in Best disease 3:00 - 4:45pm 
  Edward Adams: A0136: Quantifying photoreceptor health using automated normalised ellipsoid zone reflectivity in Age-Related Macular Degeneration
  Gongyu Zhang: A0288: AutoMorph Optimization for Enhanced Retinal Vessel Analysis in Premature Infants
  Alan Sousa da Silva A0301: EyeSAM: Unveiling the Potential of Segment Anything Model in Ophthalmic Image Segmentatio
  Ian Yeung: B0322: A Biologics Screening Clinic for Ocular Inflammatory Disease Patients in the United Kingdom (UK)
  Cecile Mejecase: A0046: Dysfunction of vitamin A metabolism and phospholipid transport contribute to dominant and recessive RDH12-retinopathies

Tuesday 7 May

Talks

• 9.23 - 9.40am
  Michael Crossland: Wearable devices for people with low vision: from LVES to Apple Vision Pro
• 9:30 - 9:45am
  Dun Jack Fu: A deep-learning approach to identifying quantitative OCT biomarkers predictive of visual deficit measured by microperimetry at 24 months in the OAKS trial
• 2:15 - 2:30pm
  Pallavi Bagga: AI-based qOCT analysis of phase 3 trials OAKS & DERBY data on the effect of pegcetacoplan on geographic atrophy
• 2:45 - 3:00pm
  Christopher Holmes: Using adaptive optics to assess hyporeflective clumps as a biomarker for progression to cRORA in the PINNACLE study
• 3:30 - 3:44pm
  Pearse Keane: RETFound: the development and use of a foundation model for retinal imaging
• 3:45 - 4:00pm
  Michael Whitehead: Pathogenic OPA1 variants disrupt calcium homeostasis in iPSC-derived retinal ganglion cells increasing their susceptibility to cell death
• 4:20 - 4:35pm
  Gavin Arno: Nanopore-based transcript amplicon sequencing for functional investigation of non-coding variants from patient blood

Poster presentations

• 8:30 -10:15am
  Mahima Jhingan: A0189: Optical coherence tomography biomarkers of individuals with uveitis on Adalimumab – preliminary data of a two year longitudinal analysis
  Thales Guimaraes: A0353: CDH23-Associated Usher Syndrome: Clinical Features, Retinal Imaging and Natural History
  Durreshahwar Hashmi B0482: UKIDS study: Quantitative multi-organ MRI imaging stratifies diabetics with cardiac & abdominal phenotypes specific to proliferative diabetic retinopathy (PDR) & clinically significant diabetic macular edema (CSME, DME)
• 1:15 -3:00pm 
  Mishank Jain: B0075: Five Year Outcomes of the Cypass supraciliary microstent in a tertiary glaucoma centre in the United Kingdom.
  Ana Paula Ribeiro Reis: B0423: Association of Mesopic Visual Sensitivities with automatically segmented Retinal Pigment Epithelium and Outer Retinal Atrophy (RORA) on Ocular Coherence Tomography (OCT)
  Katie Geraghty: B0434: The first prospective study of Toku’s CLAiR technology: advancing cardiovascular risk assessment through retinal imaging in the Middle Eastern population
  Taha Soomro: B0446: Structure and function preserved five years after hESC-RPE patch transplantation in submacular haemorrhage secondary to neovascular AMD
  William Woof: B0397: Creating the world’s largest dataset of segmented Inherited Retinal Disease features by bootstrapping manual annotations with AI
  Peter Woodward-court: B0420: Deep-Learning Hydroxychloroquine Retinopathy Detection & Augmentation using Diffusion Models
  Ismail Moghul: B0441: NEO: Advanced Automated Segmentation of Optical Coherence Tomography in Age-Related Macular Degeneration and Diabetic Macular Edema Using Deep Learning and Active Learning Strategies
  Emma Burton: B0467: Production and functional characterisation of iPSC-derived pericytes for choriocapillaris regeneration
• 3:30 - 5:15pm
  Timing Liu: B0182: The relation between leukocyte telomere length and glaucoma traits in the UK Biobank
  Bledi Petriti B0180: ATP synthase c-subunit leak is associated with aberrant cellular metabolism in glaucoma patients with the E50K Optineurin mutation
  Siyin Liu: Novel insights into Fuchs endothelial corneal dystrophy through genetic, demographic, and phenotypic correlations

Wednesday 8 May

Talks

• 10:45 - 11:00am
  Georgios Koutsocheras: Comparative analysis of anatomical and visual parameters in treatment-resistant neovascular age-related macular degeneration (nAMD) patients pre- and post-switch to faricimab: A Moorfields Analysis
• 11:00 - 11:15am   (Pacific)
  Zihan Sun: Associations of chronotype with retinal morphology in UK Biobank
• 11:30 - 11:45am
  Ana Alonso-Carriazo Fernandez: Investigating Genome Editing As A Therapeutic For Late-Onset Retinal Degeneration
• 2:15 - 2:30pm
  Bhairavi Bhatia: Impact of Disease Activity Criteria on Extending Injection Intervals in Real-World Patients with Neovascular Age-related Macular Degeneration: A Moorfields Analysis
• 2:45 - 3:00pm
  Marcela Bohn, Impact of deferring intravitreal Aflibercept for diabetic macular edema under the Covid-19 pandemic: visual outcomes after 18 months
• 3:30 - 3:45pm
  Nicole Noel, Age-Related Macular Degeneration-Like Features in the Rapidly Ageing Turquoise Killifish

Poster presentations

• 10:30 - 12:15pm 
  Sagnik Sen, B0118: IQCB1-retinopathy:Clinical and Genetic Characterization, Natural History, and Novel observations
  Samantha Malka, B0121: A single ancestral allele of the gene TMEM216 is a common cause of recessive retinitis pigmentosa in families of African ethnicity
  Faye Del Rosario Levina, B0126: Autosomal dominant optic atrophy in a large Filipino family with an OPA1 missense mutation
  Yuan Tian, A0124: Aligning multiplex immunohistochemistry with multimodal OCT imaging of the mouse retina
  Xiaofan Jiang, A0409: Epigenetic modifiers and their interactions with genetic polymorphisms in Intraocular Pressure and glaucoma
  Bernardo Souza Mendes, B0111: Extending Eye2Gene to Quantify the Phenotypic Diversity and Similarity of 63 Inherited Retinal Diseases using an Embedding Approach
  Daniel Jackson, B0153: Transcriptome analysis of patient derived microphthalmia and myopia optic vesicles identifies key pathways influencing axial length
  Karen Eastlake, B0227: Müller glia derived EVs promote recovery in Retinal ganglion like cells derived from hESC Retinal organoids in vitro
  Wanghaoming Fang, B0473: Enhancing A Fast Perimetry Algorithm Through Refined Spatial Pooling
  Gavin Arno: Assessment of the splicing-effect, in vivo, of mutations in USH2A using long-read sequencing of cDNA from nasal epithelium
  Yuan Tian, A0124: Aligning multiplex immunohistochemistry with multimodal OCT imaging of the mouse retina
• 2:15 - 4:00pm
  Praveen Patel, A0364: Retino-Vascular changes throughout the Menstrual Cycle: Associations with retinal imaging in UK Biobank
  Abraham Olvera-Barrios, A0382: Increased all-cause mortality in people with Sickle trait and diabetes after adjusting for diabetic retinopathy (DR) severity
  Hagar Khalid, B0608: Demographic and Phenotypic Analysis of Acute Macular Neuroretinopathy: Insights from a Large Single-Center Retrospective Cohort Study
  Sridevi Thottarath, B0621: Intersession repeatability and annual changes in optical coherence tomography angiography (OCTA) metrics and visual function in diabetic macular ischaemia
  Mohammad Anas, B0181: Importance of phenotype in guiding re-interrogation of genetic results to achieve the correct molecular diagnosis in retinal disease
  Omayma Al- Saei    Mariya Moosajee, B0183: Investigating the genetic diagnostic yield of primary congenital glaucoma patients undergoing whole genome sequencing
  Marlene Elisa Da Vitoria Lobo, B0368: Automated toolkit for Vascular Morphology and Pericyte Characteristics Analysis in Early Diabetic Retinopathy.
  Yukun Zhou, B0524: Accelerate the pace toward open-source research for ophthalmology
• Virginia Calder, 440: Immunological landscape in ocular health and diseases 

Thursday 9 May

Talks

• 10:15 - 11:30am
  Sheril Kirshenbaum: ARVO/Alcon Closing Keynote: Sheril Kirshenbaum - Communicating science
• 12:30 - 12:45pm
  Charlene Formento: Prevalence of mental health issues in a UK Ophthalmic Clinical Research Facility (CRF).
• 2:00 -2:15pm
  Mahi Muqit: Letter Acuity and Reading with a Subretinal Photovoltaic Implant in Geographic Atrophy
• 2:15 - 2:30pm
  Emilia Bober: Adalimumab in the Treatment of Refractory Non-infectious Scleritis: 18-Month Outcomes

Poster presentations

• 8:00 - 9:45am
  Omar Mahroo, Modelling the rod-driven electroretinogram a-wave elicited by strong flashes: insights from patients with selected post-phototransduction impairments
  Yiu Wai Chan, B0054: Validation of polygenic risk score in age-related macular degeneration prognosis: a pilot study
  Catherine A Egan, B0057: Ethnicity is not biology: retinal pigment score (RPS) to evaluate biological variability from ophthalmic imaging using machine learning
  Dominic Williamson, B0068: Accelerating clinical trial recruitment via AI-enabled pre-screening for geographic atrophy
  Rebecca Baker, B0470: Full-field electroretinography reference limits from 420 healthy subjects, derived from transference and validation of reference data between electr, B0049: Predicting aortic stenosis from colour fundus photographs from the AlzEye Study using a deep learning model.
  Nick Muthiah, B0530: Adaptive optics (AO) retinal imaging delineates retinal changes in patients at all ETDRS stages of diabetic macular ischemia, undetectable by other structural and functional imaging in mild to moderate ischemia.
  Michael D Crossland, B0646: Mental Well-Being, Loneliness and Vision-Related Quality of Life in Adults with Inherited Macular Disease
  Davide Piccolo, B0909: A cell-based assay to identify small molecules that enhance the traffic of ABCA4 misfolding variants.
•  9:00 - 9:45am
  Lee Jones: B0634: Exploring the experience of Charles Bonnet syndrome (CBS) among visually impaired military veterans: a qualitative study.
• 10:15 - 11:30am

  Sheril Kirshenbaum: ARVO/Alcon Closing Keynote: Sheril Kirshenbaum - Communicating science

• 11:45 - 1:30pm
  Igor Kozak, B0161: Structural and functional stability of intravitreal dexamethasone therapy of eyes with diabetic macular edema as assessed by Time-in-Range analysis
  Wei-Shan Tsai, B0612: Evaluating Retinal Sensitivity Losses on Microperimetry in Diabetic Macular Ischemia – One Year Result
  Hugo Chow-Wing-Bom, B0619: Assessing cortical visual field loss across the visual field
  Kirsty Michelle Clarke, B0198: Widefield OCTA for detection of Macular Ischaemia in Sickle Cell 

• 12:30 - 12:45pm
  Charlene Formento: Prevalence of mental health issues in a UK Ophthalmic Clinical Research Facility (CRF).

• 2:00 -2:15pm
  Mahi Muqit: Letter Acuity and Reading with a Subretinal Photovoltaic Implant in Geographic Atrophy

• 2:15 - 2:30pm
  Emilia Bober: Adalimumab in the Treatment of Refractory Non-infectious Scleritis: 18-Month Outcomes

• 2:00 - 3:45pm
  Claudia Liang-Peng, B0792: Beyond basal laminar drusen: expanded retinal phenotypes in membranoproliferative glomerulonephritis
  Laxmi Raja, B0798: Retinal morphological differences in atypical Parkinsonism: A cross-sectional analysis of the AlzEye cohort
  Amanda Carr, B0847: Modifying culture conditions reverses ARPE-19 cell de-differentiation

If you are a member of UCL IoO staff and students, including Honorary staff, presenting at ARVO and your name is not on this list, please email IoO.Comms@ucl.ac.uk to be added.

Links

• ARVO annual meeting