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Research News
15 September 2015
Over the last year the Institute of Ophthalmology has been awarded funding for 70 research projects, worth almost £14.5 million. We would like to thank all of the organisations that support our research and congratulate the Institute researchers whose hard work is recognised by these awards.
A full list of new projects is shown below.
| Lead | Value £ | Funder | Title | |
| Stockman, Prof Andrew | 49,112 | National institute for health research | Genotyping phenotyping and informatics | |
| Davidson, Dr Alice | 200,000 | Fight for sight | Genetic and molecular dissection of corneal endothelial dystrophies | |
| Pearson, Dr Rachael | 100,000 | Fight for sight | Do chondroitin sulphate proteoglycans in the diseased retina impair transplanted photoreceptor migration by inhibiting integrin signalling? | |
| Webster, Prof Andrew | 100,000 | Fight for sight | An investigation of the molecular pathology of developmental macular dystrophies | |
| van der Spuy, Dr Jacqui | 63,524 | Rp fighting blindness | Supporting the triage of lca patients for aip1-targeted gene therapy through the functional valildation of uncharacterised and novel aipl1 variants | |
| Luthert, Prof Philip | 10,000 | Moorfields eye charity | Fluid mechanisms of choroidal circulation | |
| Greenwood, Prof John | 30,000 | Stoneygate trust | Investigation of the potential protective effect of statins on neurovascular and neuronal function | |
| Greenwood, Prof John | 30,000 | Rosetrees trust | Investigation of the potential protective effect of statins on neurovascular and neuronal function in the context of secondary progressive multiple sclerosis | |
| Stockman, Prof Andrew | 501,464 | BBSRC | At and beyond the neural limits: visual psychophysics using an adaptive -optics visual stimulator | |
| Bailly, Dr Maryse | 34,392 | Moorfields eye hospital special trustees | The role of cellular stress in adipogenesis in thyroid eye disease (ted) | |
| Hardcastle, Prof Alison | 60,000 | Moorfields eye charity | Corneal dystrophy genetics | |
| Hardcastle, Prof Alison | 128,083 | Moorfields eye hospital special trustees | Genetic mechanism of disease for x-linked retinal degenerations; characterising a new locus | |
| Bainbridge, Prof James | 50,638 | Moorfields eye hospital special trustees | Investigating the role of myeloid cell hifs in retinal neovascularization | |
| Gazzard, Mr. Gus | 59,482 | British council for prevention of blindness | Health-related quality of life in two treatment pathways for newly diagnosed open angle glaucoma and ocular hypertension in china: an unmasked randomised controlled trial of initial selective laser trapeculoplasty versus conventional medica | |
| Lengyel, Dr Imre | 621,488 | European commission horizon 2020 | Eye-risk exploring the combined role of genetic and non genetic factors developing age-related macular degeneration: a systems level analysis of disease subgroups, risk factors, and pathways | |
| Levine, Dr Tim | 69,624 | BBSRC | Delivering structural bioinformatics to the yeast community with the HHPRY database | |
| Michaelides, Prof Michel | 33,063 | Moorfields eye hospital special trustees | Assessing retinal structure and function longitudinally in Stargardt disease using in-depth advanced phenotyping | |
| Moss, Prof Stephen | 440,269 | MRC | Lipofuscin and the complement system in retinal pigment epithelial cell biology | |
| Ohnuma, Prof Shin-Ichi | 4,000 | Great Britain Sasakawa foundation | In the footsteps of the pioneers : starting new dialogues | |
| Stockman, Prof Andrew | 18,360 | Fight for sight | Imaging fundus reflectometry for amd research and diagnosis: project update | |
| Limb, Prof Astrid | 60,563 | Moorfields eye charity | Neurotrophin expression profile of human muller glia and its implications for rgc survival and neural regeneration of the retina | |
| Daniels, Prof Julie | 37,322 | Moorfields eye charity | Equipment purchase to support stem cell research programme | |
| Garway-Heath, Prof Ted | 36,697 | National institute for health research biomedical | Theme 5: visual assessment and imaging | |
| Ohnuma, Prof Shin-Ichi | 314,783 | Moorfields eye hospital special trustees | Identification and characterisation of novel genes that influence progression and malignancy of retinoblastoma | |
| Ali, Prof Robin | 2,986,496 | MRC | Clinical trial of gene therapy for the treatment of leber congenital amaurosis | |
| Eden, Dr Emily | 432,760 | MRC | Formation and function of membrane contact sites between the er and the | |
| Keane, Dr Pearse | 977,071 | National institute for health research | Binocular OCT - reinventing the eye examination | |
| Carandini, Prof Matteo | 250,000 | Wellcome trust | Decisions and dopamine in frontal cortical circuits | |
| Hardcastle, Prof Alison | 249,910 | Moorfields eye charity | Probing rp2 mechanisms of disease using patient ips cells | |
| Ruhrberg, Prof Christiana | 100,855 | British heart foundation | Defining the role of neuropilin 1 (nrp1) in vascular permeability | |
| Sivaprasad, Miss Sobha | 79,000 | Fight for sight | Structure-function correlation in age related maculopathy | |
| Carr, Dr Amanda | 53,898 | Macular disease society | Using induced pluripotent stem cells to investigate bestrophin associated macular degeneration | |
| Ali, Prof Robin | 60,000 | Batten disease family association | Gene therapy to treat visual failure in NCL | |
| Charoy, Dr Camille | 26,250 | International brain research organization | Establishment of left-right asymmetry in developing nervous system | |
| Pearson, Dr Rachael | 171,429 | Macula vision research foundation | Retinal repair using embryonic stem cell derived photoreceptors: defining the window of transplantation competence | |
| Dart, Mr. John | 15,500 | Moorfields eye charity | The role of interleukin - 13 in the pathogenesis of ocular MMP | |
| Dart, Mr. John | 9,000 | Moorfields eye charity | Autoantigen & genetic determinants of disease in mucous membrane pemphigoid | |
| Ali, Prof Robin | 1,101,688 | MRC | Optimisation of human esc-derived photoreceptor cell differentiation | |
| Bhattacharya, Prof Shomi | 30,407 | Moorfields eye hospital special trustees | Role of spata13 in angle closure glaucoma | |
| Coffey, Prof Pete | 1,588,330 | MRC | Scalable production of RPE cells from induced pluripotent stem cell under GMP | |
| Greenwood, Prof John | 45,000 | Rosetrees trust | Identification and validation of vascular therapeutic targets for the treatment of retinal disease | |
| Hardcastle, Prof Alison | 56,000 | National institute for health research | Funding for consumables associated with corneal genetic studies and your collaborative work with Mr Steve Tuft | |
| Pearson, Dr Rachael | 46,822 | Moorfields eye hospital special trustees | Modulating gliosis to improve photoreceptor transplantation outcome in the diseased retina | |
| Webster, Prof Andrew | 45,400 | National institute for health research biomedical | Brc2_048 research funding award for rare diseases (Stargardt disease) | |
| Stockman, Prof Andrew | 416,283 | BBSRC | Multiple signals interact in flicker: recursive surround networks | |
| Murdoch, Mr. Ian | 30,000 | International glaucoma association | Primary glaucoma treatment trial in Kenya and South Africa - slt vs medication | |
| Lengyel, Dr Imre | 58,850 | Optos plc | The relationship of peripheral retinal deposits in age related macular degeneration and Alzheimers disease | |
| Dart, Mr. John | 14,550 | Fight for sight | A contemporary epidemiological case control study of acanthamoeba keratitis in the uk | |
| Dick, Prof Andrew | 15,000 | Fight for sight | Investigation of annexin-a1 expression in healthy and uveitis ocular tissue | |
| Greenwood, Prof John | 93,746 | Innovate uk | Evaluating novel monoclonal antibodies to target adam 15 for a potential novel ocular anti angiogenesis therapy | |
| Hardcastle, Prof Alison | 102,808 | RP fighting blindness | The RP genome project | |
| Khaw, Professor Sir Peng | 987,264 | National institute for health research | A novel biocompatible implant for glaukoma surgery: the biochannel device | |
| Moosajee, Dr Mariya | 14,920 | Fight for sight | Identifying universal clefting genes that cause ocular and eyelid coloboma | |
| van der Spuy, Dr Jacqui | 15,000 | Fight for sight | Supproting the triage of lca patients for aipl1-targeted gene therapy through the functional validation of uncharacterized and novel aipl1 variants | |
| Bailly, Dr Maryse | 10,000 | Rosetrees trust | Research project studying characterisation of a novel marker for trachoma scarring and validation as a potential target for anti scarring treatments in the eye | |
| Cheetham, Prof Mike | 170,000 | Fight for sight | Transplantation of human ipsc - derived photoreceptor progenitors into rodent retina to understand inherited retinal disease mechanisms and develop therapies | |
| Daniels, Prof Julie | 100,000 | Fight for sight | S/ship tbc: development of therapeutic applications for corneal stromal stem cells | |
| Garway-Heath, Prof Ted | 100,000 | Fight for sight | Which mechanisms confer resistance to glaukomatous neurodegeneration in ocular hypertention patients; relevance to neuroprotection | |
| Levine, Dr Tim | 3,750 | F2g ltd | Studying novel start proteins to develop inhibitors that sensitise invasive fungi to amphotericin b | |
| Limb, Prof Astrid | 96,020 | Moorfields eye charity | Role of gliosis in the control of the regenerative ability of Muller stem cells in the adult human retina | |
| Michaelides, Prof Michel | 139,265 | National institute for health research | Research funding award for research into achromatopsia | |
| Pearson, Dr Rachael | 27,778 | Alcon research institute | Photoreceptor replacement therapy for the treatment of retinal retina degeneration | |
| Yu Wai Man, Dr Patrick | 11,600 | National institute for health research | NIHR rare diseases translational research collaboration initiative: genotyping, phenotyping & informatics theme | |
| Lengyel, Dr Imre | 39,930 | Moorfields eye hospital special trustees | Dominic Patel multimodal imaging of zinc in the human eye | |
| Bailly, Dr Maryse | 18,500 | Moorfields eye hospital special trustees | Characterisation of a novel marker for trachoma scarring and validation as a potential target for anti-scarring treatments in the eye | |
| Bailly, Dr Maryse | 100,000 | Fight for sight | The role of src family kinases in thyroid eye disease: disease mechanisms and therapeutic potential | |
| Jeffery, Prof Glen | 75,000 | Kings college hospital nhs foundation trust | Using near infra red to modulate retinal atp and inflammation in age related macular degeneration | |
| Bhattacharya, Prof Shomi | 18,000 | Moorfields eye hospital special trustees | Why do mutations in ubiquitously expressed genes result in a retina specific disease like retinitis pigmentosa | |
| Lightman, Prof Susan | 253,750 | Moulton charitable trust | Can simvastatin significantly reduce the amount of immunosuppressive medication required by patients with sight threatening uveitis? | |
| Michaelides, Prof Michel | 168,606 | Macular disease society | Assessing retinal structure and function longitudinally in stargardt disease using in-depth advanced phenotyping in preparation for planned therapeutic intervention |