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UCL Institute of Ophthalmology

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Bailly Lab

Led by Professor Maryse Bailly.

My group uses a range of cellular models to study physiological and pathological cell behaviour regulated by cytoskeletal dynamics and mechano-regulatory pathways, particularly in the context of scarring and fibrosis. We focus on understanding the biology of fibroblasts, and how they sense and respond to mechanical and chemical clues in their environment. Our aim is to uncover how changes in fibroblasts biomechanical properties regulate tissue homeostasis in physiology and disease and to develop engineered tissue models to understand complex tissue biology and predict response to therapeutics. We work on a variety of ocular diseases including ocular fibrotic diseases such as trachoma and thyroid eye disease, glaucoma scarring, myopia, cancer, and inflammation.