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Publications and resources

Read selected Centre for Clinical Microbiology publications and access resources.

Below are selected recent publications by staff at the Centre for Clinical Microbiology.  Further publications can be found via the UCL Discovery website.

Selected publications

June 2019

Tuberculosis and leprosy associated with historical population movements in Europe and beyond – an overview based on mycobacterial ancient DNA.
Donoghue, H.D. (2019) Annals of Human Biology  

April 2019

The earliest recorded case of lepromatous leprosy in continental Croatia.
Bedić, Ž., Šlaus, M., Donoghue, H.D. J Archaeol Sci Reports 2019, 25, 47–55.

March 2019

The International Journal of Infectious Diseases TB Series
Chief guest editors Zumla A and Petersen E.

Revolutionary new treatment regimens for multidrug-resistant tuberculosis
McHugh TD, Honeyborne I, Lipman M, Zumla A. Lancet Infectious Dis. 2019 Mar;19(3):233-234 

Latent tuberculosis infection: diagnostic tests and when to treat
Petersen E, Chakaya J, Jawad FM, Ippolito G, Zumla A. Lancet Infect Dis. 2019 Mar;19(3):231-233.  

Towards optimal treatment for latent Mycobacterium tuberculosis infection
Abubakar I, Chakaya J, Maeurer M, Zumla A. Lancet Respir Med. 2019 Mar;7(3):195-197.

Isoniazid preventive therapy for children in sub-Saharan Africa
Meremikwu M, Zumla A. Lancet Respir Med. 2019 Mar;7(3):197-199 

After the UNGA high-level meeting on Tuberculosis - what next and how? 
Sunvanand S, Ditiu L, Zumla A. Lancet Global Health: 2019: March 12, 2019  

February 2019

Smartphone-enabled video-observed versus directly observed treatment for tuberculosis: a multicentre, analyst-blinded, randomised, controlled superiority trial
Story, A; Aldridge, RW; Smith, CM; Garber, E; Hall, J; Ferenando, G; Possas, L; Hemming, S; Wurie, F; Luchenski, S; Abubakar, I; McHugh, TD; White, PJ; Watson, JM; Lipman, M; Garfein, R; Hayward, AC
Lancet 10.1016/S0140-6736(18)32993-3

January 2019

Monkeypox - Enhancing public health preparedness for an emerging lethal human zoonotic epidemic threat in the wake of the smallpox post-eradication era.
Petersen E, Abubakar I, Ihekweazu C, Heymann D, Ntoumi F, Blumberg L, Asogun D, Mukonka V, Lule SA, Bates M, Honeyborne I, Mfinanga S, Mwaba P, Dar O, Vairo F, Mukhtar M, Kock R, McHugh TD, Ippolito G, Zumla A.
Int J Infect Dis. 2019 Jan;78:78-84. doi: 10.1016/j.ijid.2018.11.008.

Airway microbiome in adult survivors of extremely preterm birth: the EPICure study.
Rofael SAD, McHugh TD, Troughton R, Beckmann J, Spratt D, Marlow N, Hurst JR.
Eur Respir J. 2019 Jan 10;53(1). pii: 1801225. doi: 10.1183/13993003.01225-2018.

December 2018

Detection of carbapenemases, AmpC and ESBL genes in Acinetobacter isolates from ICUs by DNA microarray.
Uddin F, McHugh TD, Roulston K, Platt G, Khan TA, Sohail M.
J Microbiol Methods. 2018 Dec;155:19-23

Achieving sustainable development goals for HIV/AIDS in the Republic of the Congo - Progress, obstacles and challenges in HIV/AIDS health services.
Ghoma Linguissi LS, Lucaccioni V, Bates M, Zumla A, Ntoumi F.
Int J Infect Dis. 2018 Dec;77:107-112.

November 2018

Airway Microbiome in Adult Survivors of Extremely Preterm Birth (The EPICure Study).
Rofael SAD, McHugh TD, Troughton R, Beckmann J, Spratt D, Marlow N, Hurst JR.
Eur Respir J. 2018 Nov 21

Monkeypox - Enhancing public health preparedness for an emerging lethal human zoonotic epidemic threat in the wake of the smallpox post-eradication era.
Petersen E, Abubakar I, Ihekweazu C, Heymann D, Ntoumi F, Blumberg L, Asogun D, Mukonka V, Lule SA, Bates M, Honeyborne I, Mfinanga S, Mwaba P, Dar O, Vairo F, Mukhtar M, Kock R, McHugh TD, Ippolito G, Zumla A.
Int J Infect Dis. 2018 Nov 16;78:78-84.

Improving access to multi-drug resistant tuberculosis diagnostic and health services for refugees and migrants.
Zumla A, Abubakar I.
BMC Med. 2018 Nov 30;16(1):221.

Universal health coverage for refugees and migrants in the twenty-first century.
Abubakar I, Zumla A.
BMC Med. 2018 Nov 26;16(1):216.

Children infected by human herpesvirus 6B with febrile seizures are more likely to develop febrile status epilepticus: A case-control study in a referral hospital in Zambia.
Tembo J, Chandwe K, Kabwe M, Chilufya M, Ciccone O, Mpabalwani E, Ablashi D, Zumla A, Chen T, Bates M.
J Med Virol. 2018 Nov;90(11):1757-1764

October 2018

Gender differences in tuberculosis treatment outcomes: a post hoc analysis of the REMoxTB study.
Murphy ME, Wills GH, Murthy S, Louw C, Bateson ALC, Hunt RD, McHugh TD, Nunn AJ, Meredith SK, Mendel CM, Spigelman M, Crook AM, Gillespie SH; REMoxTB consortium.
BMC Med. 2018 Oct 17;16(1):189.

Evaluation of the EntericBio CPE assay for the detection of carbapenemase-producing organisms.
Vanstone GL, Wey E, Mack D, Smith ER, Balakrishnan I.
J Med Microbiol. 2018 Dec;67(12):1728-1730. doi: 10.1099/jmm.0.000851. Epub 2018
Oct 15. PubMed PMID: 30320545.

September 2018

Accelerating the development of therapeutic strategies for drug-resistant tuberculosis.
Vjecha MJ, Tiberi S, Zumla A.
Nat Rev Drug Discov. 2018 Sep;17(9):607-608.

Advancing global tuberculosis control after the UNGA-HLM.
Marais B, Zumla A.
Lancet. 2018 Sep 29;392(10153):1096-1097. doi: 10.1016/S0140-6736(18)32361-4. Epub 2018 Sep 24

The historic and unprecedented United Nations General Assembly High Level Meeting on Tuberculosis (UNGA-HLM-TB)-'United to End TB: An Urgent Global Response to a Global Epidemic'.
Zumla A, Petersen E.
Int J Infect Dis. 2018 Oct;75:118-120. doi: 10.1016/j.ijid.2018.09.017. Epub 2018 Sep 19.

Effectiveness of service models and organisational structures supporting tuberculosis identification and management in hard-to-reach populations in countries of low and medium tuberculosis incidence: a systematic review.
Heuvelings CC, Greve PF, de Vries SG, Jelle Visser B, Bélard S, Janssen S, Cremers AL, Spijker R, Shaw E, Hill RA, Zumla A, Sandgren A, van der Werf MJ, Grobusch MP.
BMJ Open. 2018 Sep 8;8(9)

August 2018

Middle East respiratory syndrome coronavirus: risk factors and determinants of primary, household, and nosocomial transmission.
Hui DS, Azhar EI, Kim YJ, Memish ZA, Oh MD, Zumla A.
Lancet Infect Dis. 2018 Aug;18(8):e217-e227.

An evaluation of the performance of the Dynamiker® Fungus (1-3)-β-D-Glucan Assay to assist in the  diagnosis of Pneumocystis pneumonia.
White PL, Posso RB, Gorton RL, Price JS, Wey E, Barnes RA.
Med Mycol. 2018 Aug 1;56(6):778-781. doi:10.1093/mmy/myx097. PubMed PMID: 29087494.

July 2018

Toxicity associated with tuberculosis chemotherapy in the REMoxTB study.
Tweed CD, Crook AM, Amukoye EI, Dawson R, Diacon AH, Hanekom M, McHugh TD, Mendel CM, Meredith SK, Murphy ME, Murthy SE, Nunn AJ, Phillips PPJ, Singh KP, Spigelman M, Wills GH, Gillespie SH.
BMC Infect Dis. 2018 Jul 11;18(1):317

Direct Whole-Genome Sequencing of Sputum Accurately Identifies Drug-Resistant Mycobacterium tuberculosis Faster than MGIT Culture Sequencing.
Doyle RM, Burgess C, Williams R, Gorton R, Booth H, Brown J, Bryant JM, Chan J, Creer D, Holdstock J, Kunst H, Lozewicz S, Platt G, Romero EY, Speight G, Tiberi S, Abubakar I, Lipman M, McHugh TD, Breuer J.
J Clin Microbiol. 2018 Jul 26;56(8)

Cell-wall synthesis and ribosome maturation are co-regulated by an RNA switch in Mycobacterium tuberculosis.
Schwenk S, Moores A, Nobeli I, McHugh TD, Arnvig KB.
Nucleic Acids Res. 2018 Jun 20;46(11):5837-5849

Advancing political will to end the tuberculosis epidemic.
Herbert N, Masham BS, Suttie BA, Sharma V, Albani S, Domenti O, Flurry R, Oliver M, Zumla A.
Lancet Infect Dis. 2018 Jul;18(7):711-712.

Liver toxicity associated with tuberculosis chemotherapy in the REMoxTB study.
Tweed CD, Wills GH, Crook AM, Dawson R, Diacon AH, Louw CE, McHugh TD, Mendel C, Meredith S, Mohapi L, Murphy ME, Murray S, Murthy S, Nunn AJ, Phillips PPJ, Singh K, Spigelman M, Gillespie SH.
BMC Med. 2018 Mar 28;16(1):46

Concrete action now: UN High-Level Meeting on Tuberculosis.
Herbert N, Sharma V, Masham BS, Sheehan BS, Hauser J, Zumla A.
Lancet Infect Dis. 2018 Jul;18(7):709-710.

Tuberculosis: progress and advances in development of new drugs, treatment regimens, and host-directed therapies.
Tiberi S, du Plessis N, Walzl G, Vjecha MJ, Rao M, Ntoumi F, Mfinanga S, Kapata N, Mwaba P, McHugh TD, Ippolito G, Migliori GB, Maeurer MJ, Zumla A.
Lancet Infect Dis. 2018 Jul;18(7):e183-e198. doi: 10.1016/S1473-3099(18)30110-5. Epub 2018 Mar 23. Review

Tuberculosis: progress and advances in development of new drugs, treatment regimens, and host-directed therapies.
Tiberi S, du Plessis N, Walzl G, Vjecha MJ, Rao M, Ntoumi F, Mfinanga S, Kapata N, Mwaba P, McHugh TD, Ippolito G, Migliori GB, Maeurer MJ, Zumla A.
Lancet Infect Dis. 2018 Jul;18(7):e183-e198

Tuberculosis: advances and challenges in development of new diagnostics and biomarkers.
Walzl G, McNerney R, du Plessis N, Bates M, McHugh TD, Chegou NN, Zumla A.
Lancet Infect Dis. 2018 Jul;18(7):e199-e210. doi: 10.1016/S1473-3099(18)30111-7. Epub 2018 Mar 23. Review.

June 2018

New drug therapies for the management of drug-resistant tuberculosis.
Bowman C1, Davies HG2, Wey E3.
Br J Hosp Med (Lond). 2018 Jun 2;79(6):C90-C92. doi: 10.12968/hmed.2018.79.6.C90.

May 2018

Pretreatment chest x-ray severity and its relation to bacterial burden in smear positive pulmonary tuberculosis.
Murthy SE, Chatterjee F, Crook A, Dawson R, Mendel C, Murphy ME, Murray SR, Nunn AJ, Phillips PPJ, Singh KP, McHugh TD, Gillespie SH; REMoxTB Consortium.
BMC Med. 2018 May 21;16(1):73

Limiting consumption in tuberculosis: current concepts in anti-tuberculosis treatment in the critically ill patient.
Mer M, Zumla A, Dünser MW.
Intensive Care Med. 2018 May 11

Mitigating the risks of global spread of Lassa fever at the 2018 Hajj pilgrimage.
Gautret P, Okolo S, Elachola H, Zumla A, Memish ZA.
Travel Med Infect Dis. 2018 May - Jun;23:99-100

Global spread of antibiotic-resistant bacteria and mass-gathering religious events.
Zumla A, Azhar EI, Hui DS, Shafi S, Petersen E, Memish ZA.
Lancet Infect Dis. 2018 May;18(5):488-490.

Ancient genomes reveal a high diversity of Mycobacterium leprae in medieval Europe.
Schuenemann VJ, Avanzi C, Krause-Kyora B, Seitz A, Herbig A, Inskip S, Bonazzi M, Reiter E, Urban C, Dangvard Pedersen D, Taylor GM, Singh P, Stewart GR, Velemínský P, Likovsky J, Marcsik A, Molnár E, Pálfi G, Mariotti V, Riga A, Belcastro MG, Boldsen JL, Nebel A, Mays S, Donoghue HD, Zakrzewski S, Benjak A, Nieselt K, Cole ST, Krause J.
PLoS Pathog. 2018 May 10;14(5):e1006997

April 2018

Tuberculosis series.
Silva DR, Mello FCQ, Kritski A, Dalcolmo M, Zumla A, Migliori GB.
J Bras Pneumol. 2018 Apr;44(2):71-72.

New and repurposed drugs to treat multidrug- and extensively drug-resistant tuberculosis.
Silva DR, Dalcolmo M, Tiberi S, Arbex MA, Munoz-Torrico M, Duarte R, D'Ambrosio L, Visca D, Rendon A, Gaga M, Zumla A, Migliori GB.
J Bras Pneumol. 2018 Apr;44(2):153-160

The global tuberculosis epidemic and progress in care, prevention, and research: an overview in year 3 of the End TB era.
Floyd K, Glaziou P, Zumla A, Raviglione M.
Lancet Respir Med. 2018 Apr;6(4):299-314

Tuberculosis: advances and challenges in development of new diagnostics and biomarkers.
Walzl G, McNerney R, du Plessis N, Bates M, McHugh TD, Chegou NN, Zumla A.
Lancet Infect Dis. 2018 Jul;18(7):e199-e210

Evaluation of the efficacy of valproic acid and suberoylanilide hydroxamic acid (vorinostat) in enhancing the effects of first-line tuberculosis drugs against intracellular Mycobacterium tuberculosis.
Rao M, Valentini D, Zumla A, Maeurer M.
Int J Infect Dis. 2018 Apr;69:78-84.

Urgent need for multi-site controlled trials for CMV pneumonia treatment in African children.
Tembo J, Moraleda C, Rojo P, Zumla A, Bates M.
Int J Tuberc Lung Dis. 2018 Apr 1;22(4):469-470.

Tuberculosis research and development: seeding the future.
Lienhardt C, Zumla A, Gebreselassie N, Frick M, Gray G, Kasaeva T, Raviglione M.
Lancet Respir Med. 2018 Apr;6(4):242-244.

B cells or T cells in TB: a continuing conundrum.
Maeurer M, Rao M, Zumla A.
Lancet Respir Med. 2018 Apr;6(4):237-238.

March 2018

Taking forward the Stop TB Partnership and World Health Organization Joint Theme for World TB Day March 24th 2018 - "Wanted: Leaders for a TB-Free World. You can make history. End TB".
Tiberi S, Petersen E, Maeurer M, Ntoumi F, Yeboa-Manu D, Mwaba P, Vilaplana C, Dar O, Bates M, Corrah T, Rao M, Kapata N, Azhar EI, Memish ZA, Mfinanga S, Aseffa A, Ippolito G, Migliori GB, Zumla A.
Int J Infect Dis. 2018 Mar;68:122-124

February 2018

Improving the detection of carbapenemase-producing organisms (CPO) in a low-prevalence setting: evaluation of four commercial methods and implementation of an algorithm of testing.
Vanstone GL, Woodhead S, Roulston K, Sharma H, Wey E, Smith ER, Mack D, Balakrishnan I.
J Med Microbiol. 2018 Feb;67(2):208-214. doi: 10.1099/jmm.0.000674. PubMed PMID: 29388538.

January 2018

Analogues of Disulfides from Allium stipitatum Demonstrate Potent Anti-tubercular Activities through Drug Efflux Pump and Biofilm Inhibition.
Danquah CA, Kakagianni E, Khondkar P, Maitra A, Rahman M, Evangelopoulos D, McHugh TD, Stapleton P, Malkinson J, Bhakta S, Gibbons S.
Sci Rep. 2018 Jan 18;8(1):1150.

Chloroform extract of turmeric inhibits biofilm formation, EPS production and motility in antibiotic resistant bacteria.
Hayat S, Sabri AN, McHugh TD.
J Gen Appl Microbiol. 2018 Jan 15;63(6):325-338.

Relationship Between Viremia and Specific Organ Damage in Ebola Patients: A Cohort Study.
Lanini S, Portella G, Vairo F, Kobinger GP, Pesenti A, Langer M, Kabia S, Brogiato G, Amone J, Castilletti C, Miccio R, Capobianchi MR, Strada G, Zumla A, Di Caro A, Ippolito G; INMI-EMERGENCY EBOV Sierra Leone Study Group .
Clin Infect Dis. 2018 Jan 6;66(1):36-44.