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Consultant Physician & Hepatologist
Research area
Autoimmune and Cholestatic Liver Diseases, and Liver Transplantation.
Research programme
Research summary
Autoimmune liver diseases include Primary Biliary Cirrhosis (PBC), Autoimmune Hepatitis (AIH) and Primary Sclerosing Cholangitis (PSC) and in combination account for 15% of the liver transplants undertaken within the UK.
Our group is focused on each of these diseases and we actively collaborate in national (UK-PBC, UK-AIH, UK-PSC) and international consortia (Global PBC and the International PSC Study Group (iPSCSG). There is an active program of biobanking in each of these diseases. We are undertaking a range of projects and have a particular interest in non-invasive assessment of disease severity and stratification of prognosis.
We have a further interest in immune mechanisms after liver transplantation in collaboration with the Institute of Immunity and Transplantation and the Renal Unit at the Royal Free.
We utilise a number of experimental approaches to examine immune cell function including human blood cells, cell line models of PID generated through targeted silencing of immune genes and murine models of PID. Our work closely collaborates with departmental and national research aimed at identifying the genes that cause PID.