Research
Cluster 1: Immune tolerance
![](https://www.ucl.ac.uk/immunity-transplantation/sites/immunity_transplantation/files/styles/large_image/public/215-research-immunereg.jpg?itok=XSLU4tfZ)
Immune regulation
Our goal is to better understand immune regulation at a cellular and molecular level, apply this knowledge to clinical conditions, and develop strategies to correct defective regulation with new biological therapies.
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Transplantation
We study the nature of immune responses in liver and renal transplant patients. We also study immune stimulation to develop tolerance-inducing interventions to prevent immune attack and rejection.
Cluster 2: Immunotherapy
![](https://www.ucl.ac.uk/immunity-transplantation/sites/immunity_transplantation/files/styles/large_image/public/215-research-immunothercancer.jpg?itok=07Xani4U)
Cancer immunity
We research the mechanisms of cancer immunity and cancer-induced tolerance in patients and in experimental models. Genetic engineering of immune cells provides and opportunity to produce cancer-specific T cells that are resistant to cancer-induced immune suppression.
![](https://www.ucl.ac.uk/immunity-transplantation/sites/immunity_transplantation/files/styles/large_image/public/215-research-viralimmunity.jpg?itok=gDbtoNDq)
Viral immunity
Chronic infection with hepatitis B virus, cytomegalovirus and HIV is associated with defective immunity. Uncovering the mechanisms of immune deviation provides a platform for developing immune enhancing therapies to achieve viral immunity in chronic infection.
Cluster 3: Inherited disease
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Inherited diseases
We delivered the first successful gene therapy for haemophilia B using AAV based gene delivery. This work has provided a strong basis to expand this form of gene therapy to other conditions.
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Immune deficiency
We focus on improving early diagnosis and therapy of primary immunodeficiency by joining detailed genomic analysis, mechanistic immune function studies and comprehensive clinical data.